laporan praktikum kolesterol revisi

8/13/2019 Laporan Praktikum Kolesterol Revisi

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LAPORAN PRAKTIKUM BIOKIMIABLOK ENDOKRIN DAN METABOLISMEPEMERIKSAAN KOLESTEROL DARAH

(Metode CHOD-PAP)

Oleh :Kelompok C !

Marlina Jaya Diputri G1A012009Rahayu Nurmalia G1A012020Firyal Maulia G1A012038Kurniawan Wijaya G1A012055Dwi ama! Aji G1A0120"3

Kri!na Dwiantama G1A01209#$%nri &tami G1A012099Ra!yi' (uhur &tama G1A01210)D%*+rah ,ri+na -%.a G1A01211"Fari!!a &tami G1A012121/n% Ann Mari% G1A012123

ani ahyani 4utri G1A0121#"Ri!ma G1A0100#5

A"#"te$ Do"e$ :Ste%&$'" A # &$to *

+,A ,, ,.

UNI/ERSITAS 0ENDERAL SOEDIRMAN1AKULTAS KEDOKTERAN DAN ILMU-ILMU KESEHATAN

0URUSAN KEDOKTERANPUR*OKERTO

! ,2


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LEMBAR PEN+ESAHAN

PEMERIKSAAN KOLESTEROL(METODE CHOD-PAP)

Oleh :Kelompok C !

Marlina Jaya Diputri G1A012009Rahayu Nurmalia G1A012020Firyal Maulia G1A012038Kurniawan Wijaya G1A012055Dwi ama! Aji G1A0120"3Kri!na Dwiantama G1A01209#$%nri &tami G1A012099Ra!yi' (uhur &tama G1A01210)D%*+rah ,ri+na -%.a G1A01211"Fari!!a &tami G1A012121/n% Ann Mari% G1A012123

ani ahyani 4utri G1A0121#"Ri!ma G1A0100#5

Di!u!un untu m%m%nuhi p%r!yaratan m%n.i uti ujian pra ti um i+ imiaK%'+ t%ran *l+ 6n'+ rin 'an M%ta*+li!m% pa'a Fa ulta! K%'+ t%ran 'an /lmu7/lmu K%!%hatan Juru!an K%'+ t%ran &ni %r!ita! J%n'%ral $+%'irman 4urw+ %rt+

Dit%rima 'an 'i!ah an4urw+ %rt+ , t+*%r 2013

A"#"te$

Ste%&$'" A # &$toNIM +,A ,, ,.

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I PENDAHULUAN

A 0'd'l4%m%ri !aan K+l%!t%r+l Darah :M%t+'% ,D74A4;

B H& # d&$ T&$33&l

$%nin ) , t+*%r 2013

C T'4'&$

1< Maha!i!wa a an 'apat m%n.u ur a'ar +l%!t%r+l '%n.an m%t+'% ,D74A4ara ti'a

lan.!un. *%ra!al 'ari 'i%t< $%p%rti halnya '%n.an il+mi r+n tri.li!%ri'a'ari -(D( 'i'%.ra'a!i +l%h lip+pr+t%in lipa!%< -(D( remnant :!i!a; atau

lip+pr+t%in '%n!ita! !%'an. : intermediet-density lipoprotein ?/D(; ma!ih

t%tap a'a !%t%lah *anya tri.li!%ri'nya yan. 'i %luar an< 4arti %l ini aya

a an pr+t%in !p%!i i :ap+pr+t%in 7100 'an 6;< /D( !%>ara lan.!un.

'i %luar an 'ari !ir ula!i +l%h int%ra !inya '%n.an r%!%pt+r ap+pr+t%in ?6

atau 'i +n %r!i m%nja'i (D(< K+n %r!i /D( m%nja'i (D( m%lalui %rja

%n im lipa!% h%pati 'i!%rtai '%n.an p%n.%luaran tri.li!%ri'a 'an

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ap+pr+t%in 6 'an hal ini t%rja'i 'i p%rmu aan h%pat+!it< D% % pa'a

ap+pr+t%in 6 'ari -(D( manu!ia m%n.a i*at an t%rja'inya a umula!i

at%r+.%ni -(D( remnant :*7-(D(; !%hin..a t%rja'i hip%rlip+pr+t%in%mia

tip% ///ara *%ri atan

'%n.an r%!%pt+r 7100?6 m%m*ran pla!ma :r%!p%t+r (D(; 'i h%par 'an

jarin.an % !trah%pati < &mumnya +l%!t%r+l 'an ap+pr+t%in 7100

'i %luar an m%lalui pr+!%! 'i h%par< 4%m*%*a!an +l%!t%r+l 'alam (D( %

'alam jarin.an a an m%n% an !int%!i! m+l% ul +l%!t%r+l yan. *aru%rna< $%lain itu

% 'alam u!u! ju.a 'i!% r%!i an +l%!t%r+l yan. *%ra!al 'ari hati *%r!ama

'%n.an %mp%'u< $%mua tri.li!%ri'a 'an +l%!t%r+l yan. a'a 'i u!u! ini

%mu'ian 'i!%*ut !%*a.ai l%ma % !+.%n :Wahyu'i 2009;%pat tim*ulnya

at%r+! l%r+!i! !%'an. an h+rm+n !% ! wanita :%!tr+.%n; m%mpunyai

% % p%rlin'un.an t%rha'ap at%r+! l%r+!i!< A an t%tapi pa'a wanita

m%n+pau!% m%mpunyai r%!i + l%*ih *%!ar t%rha'ap t%rja'inya

at%r+! l%r+!i! 'i*an'in. an wanita pr%m%n+pau!%ara *%rpa!an.an yaitu

!atu .%n 'ari i*u 'an !atu .%n 'ari ayah !%hin..a a'ar hip%rlipi'%mia

tin..i 'apat 'ia i*at an +l%h a t+r 'i!lipi'%mia prim%r ar%na a t+r

%lainan .%n%ti

Bri.li!%ri'a 'an +l%!t%r+l yan. 'i!int%!i! 'i hati 'i!% r%!i %

'alam !ir ula!i !%*a.ai lip+pr+t%in 100< Dalam !ir ula!i tri.li!%ri'a

'i -(D( a an m%n.alami hi'r+li!i! +l%h %n im lip+pr+t%in lipa!%

:(4(; 'an -(D( *%ru*ah m%nja'i /D( yan. ju.a a an m%n.alami

hi'r+li!i! 'an *%ru*ah m%nja'i (D(< $%*a.ian 'ari -(D( /D( 'an

(D( a an m%n.an. ut +l%!t%r+l %!t%r %m*ali % hati< (D( a'alahlip+pr+t%in yan. palin. *anya m%n.an'un. +l%!t%r+l< $%*a.ian 'ari

+l%!t%r+l 'i (D( a an 'i*awa % hati 'an jarin.an !t%r+i'+.%ni

lainnya !%p%rti %l%njar a'r%nal t%!ti! 'an + arium yan. m%mpunyai

r%!%pt+r untu +l%!t%r+l (D(< $%*a.ian la.i 'ari +l%!t%r+l (D(

a an m%n.alami + !i'a!i 'an 'itan. ap +l%h r%!%pt+r scavenger A

:$R7A; 'i ma r+ a. 'an a an m%nja'i !%l *u!a : foam cell ;< Ma in

*anya a'ar +l%!t%r+l7(D( 'alam pla!ma ma in *anya yan. a an

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m%n.alami + !i'a!i 'an 'itan. ap +l%h !%l ma r+ a.< Jumlah

+l%!t%r+l yan. a an t%r+ !i'a!i t%r.antun. 'ari a'ar +l%!t%r+l yan.

t%r an'un. 'i (D(< %*%rapa %a'aan m%mp%n.aruhi tin. at + !i'a!i

!%p%rti :$u'+y+ %t al< 2009;=

a; M%nin. atnya jumlah (D( !%p%rti pa'a !in'r+m m%ta*+li 'an

'ia*%t%! m%litu!il mi! in +l%!t%r+l

yan. m%n.an'un. ap+lipr+t%in :ap+; A 'an 6= 'an 'i!%*ut D(

nascent < D( nascent *%ra!al 'ari u!u! halu! 'an hati m%mpunyai

*%ntu .%p%n. 'an m%n.an'un. ap+lipr+t%in A1< D( nascent a an

m%n'% ati ma r+ a. untu m%n.am*il +l%!t%r+l yan. t%r!impan 'i

ma r+ a.< $%t%lah m%n.am*il +l%!t%r+l 'ari ma r+ a.< D( nascent

*%ru*ah m%nja'i D( '%wa!a yan. *%r*%ntu *ulat< A.ar 'apat

'iam*il +l%h D( nascent +l%!t%r+l : +l%!t%r+l *%*a!; 'i*a.ian

'alam 'ari mi r+ a. haru! 'i*awa % p%rmu aan m%m*ran !%lma r+ a. +l%h !uatu tran!p+rt%r yan. 'i!%*ut adenosine

triphosphate-'inding cassette transporter 71 atau 'i!in. at A 71ah< 4%r'arahan *%rupa p%r'arahan

intra!%r%*ral yaitu pa'a jarin.an +ta 'an p%r'arahan !u*ara n+i'

'imana !u*ara n+i' m%rupa an lapi!an *awah jarin.an p%m*un. u!

+ta :4in +n I A!anti 2010;< $tr+ % tip% ini 'i!%*ut intra!%r%*ral

h%m+ra.i prim%r :(in'l%y 2008;ara 'i! a!ia atau a a!ia .an..uan !%n!+ri 'an

.an..uan m+t+ri : %jan.;a'an.an + !i.%n !%hin..a m%m%rlu an

!uplai 'ari 'arah art%ri intra ranial< Apa*ila aliran 'arah m%nurun ma a

a an t%rja'i .an..uan un.!i +ta yan. m%n.a i*at an +ta ti'a a an

*%rtahan hi'up l%*ih lama< K%a'aan ini m%nim*ul an t%rja'inya i! %mi

jarin.an +ta yan. *%rlanjut pa'a i! %mi n%ur+n 'an *%ra hir pa'a

%matian !%l +ta :$i!want+ 2005;ul pa'a p%n'%rita !tr+ %

:Mah%n'ra I Ra>hmawati 2005;=

1; $tr+ % *%rulan.

2; -a!+!pa!m%? +ntra !i p%m*uluh 'arah yan. m%ny%*a* an i! %mi

+ta t+tal !%hin..a 'apat t%rja'i %ru!a an t+tal

3; 6'%ma +ta m%ny%*a* an h%rnia +ta 'an %matian

#; M%mar :'% u*i!; t%rja'i %ti a a'a *a.ian tu*uh yan. m%nja'i

lumpuh !%hin..a haru! !%rin. 'i.%ra an 'an 'ipin'ah an !%>ara

t%ratur

2 Pe$ &k#t 0&$t'$3 Ko o$e

& De%#$#"#

4%nya it jantun. +r+n%r atau 'i!%*ut ju.a p%nya it art%ri +r+n%r

a'alah tip% %lainan p%m*uluh 'arah yan. t%rma!u 'alam at%.+ri umum

'ari atherosclerosis. /!tilah atherosclerosis *%ra!al 'ari *aha!a unani=athere yan. *%rarti *u*ur *%rl%ma H 'an s)leros yan. *%rarti %ra!Hu ny%ri

t%r!%*ut : !ational Heart$ L#ng$ and Blood &nstit#te 2012;u upi

%*utuhan tu*uh< airan a an t%r umpul 'i paru7paru !%hin..a

m%m*uat !ulit *%rnapa!< Bin. at %parahan .%jala7.%jala ini *%ra.amu p%m*%ntu an tr+m*u!< 4a'a in ar mi+ ar' a ut

+ lu!i yan. t%rja'i l%*ih m%ny%luruh 'i*an'in. an pa'a an.ina yan.

ti'a !ta*il yan. + lu!inya *ia!anya hanya !%*a.ian< 6m*+li!m% 'i hilir

tr+m*u! 'apat m%nim*ul an mi r+in ar :Gr%>h 2008;+ran 'arah

'ari %ntri %l iri % atrium iri< 4%ny%*a* r%.ur.ita!i mitral pa'a

umumnya a'alah pr+lap! atup mitral 'an !%ran.an jantun.hu%l%r 2011;

laporan praktikum kolesterol revisi

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