penyakit sistemik dan degenerasi

8/18/2019 Penyakit Sistemik Dan Degenerasi

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PENYAKIT SISTEMIK DAN

DEGENERATIFDr. Sriana Wulansari, SpM


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• .


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PenyakitSistemik

Manifest pada MataRetinopathy

Uveitis


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Retinopat

hy1. IN!"SI• #u$er%ulosis

• &at's%rat%h diseases

• !ndo(en %andida !ndophthalmitis• )sper(ilus %andida !ndophthalmitis

• Syphiliti% %horeoretinitis

• #oo%ariasis• &o%%idioidomy%osis

• &ytome(alovirus

*I+


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Retinopathy

. De(enerasi Retina

1. "elainan meliputi sistem or(an-

Infantil syndr

ardet'iedl %omple of disease

Neomuskular disorder&an%er assosiated retinopathy /&)R0

. Defek meta$olik

)l$inisme&NS meta$oli% a$normalities

Mito%ondrial DN) disorder


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• . Sistemi% Dru( #o2i%ity

• &hloro3uin derivatives

• Phenothia4ine, &hlorproma4ine• #amo2ifen, %antha2antine,

metho2i5uran anesthesia

• !tham$uthol, di(italis

Retinopathy


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•)nkylosin( spondilitis•Reiter syndr /nonspesi6% uretritis, polyarthritis,%on7un(tival in5amation0•Psoriati% arthritis

•eh%et syndrom /a%ute iritis d( hipopion, aphtousstomatitis, (enital

ul%eration0•+iral infe%tion /adenovirus, in5uen4a, *erpeti%disease, %itome(alovirus, !pstein $arr virus,

ru$elaa, measles0•un(al infe%tion /%andida, histoplasmosis0•Proto4oa infe%tion /tooplasma0ariasis, %y%ti%er%osis0•a%terial infe%tion - Syphilis, #&, leptospirosis,lyme disease•*elminti% infe%tion /too%•Dru( indu%e /rifa$utin, %idovir0


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)(e'related Ma%ular De(eneration/)MD0

• 9eadin( %ause of severe%entral visual a%uity loss

• :; y.o < ==

•De(enerative diseasea>e%t - – RP!

– ru%h?s mem$rane

– &horio%apillaris

• Divided - – Nonneovas%ular /Dry

type0

– Neovas%ular /Wet type0


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Non Neovascular AMD

• &ommon type

• Mild de%rease of vision

• *allmark - Drusen

/ (ranular material @ithin

ru%h?s mem$rane0

• )$normalities of RP! -(eo(raphi% A non(eo(raphi% atrophy, fo%al

hyperpi(mentation0• #2 - edu%ation B follo@

up, Mi%ronutrients


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Neovascular AMD

• Severe visual loss

• Si(n - – Soft drusen /%on5uent0

– RP! deta%hment – Su$retinal elevation of

5uid,$lood

– &horoidal

neovas%ulari4ation /&N+0• )n%illary test - ),

Indo%yanine (reenan(io(raphy /I&C)0,


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&N+ in(ro@th of ne@

vessels from%horio%apilaris throu(h a

$reak of ru%h?smem$rane, into su$'pi(ment epithelial spa%e

FFA

OCT

Choroidal

neovascularization CN!"


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Mana(ement of Neovas%ular)MD

• 9aser photo%oa(ulation /thermal laser0

• Photodynami% #herapy /PD#0 nonthermal laser @ith vertepor6n in7e%tion

• #riam%inolon /steroid0 intravitreal in7e%tion• )nti +!C intravitreal in7e%tion

– Pe(aptani$ sodium /Ma%u(en0

– Rani$i4uma$ /9u%entis0

– eva%i4uma$ /)vastin0• &om$ine - PD# E Intravitreal in7e%tion


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#erima

"asih

penyakit sistemik dan degenerasi

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