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Pemeriksaan LaboratoriumGangguan Sistim Endokrin

Dr. D.A.A.Mandagi

Bagian Patologi Klinik

FK UNSRAT

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TIU / TIK

TIU : Mengenal beberapa pemeriksaan laboratorium

pada gangguan endokrin.

TIK :

1. Dapat mengenali beberapa pemeriksaan

laboratorium pada gangguan endokrin.

2. Dapat mengenali metoda pemeriksaan laboratorium

pada gangguan endokrin.

3. Dapat mengenali faktor pra-analitik pemeriksaanlaboratorium pada gangguan endokrin.

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Cell Signaling

Endocrine Signaling

Neuroendocrine Signaling

Autocrine Signaling Paracrine Signaling

Juxtacrine Signaling

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ENDOCRINE GLANDS

Hipothalamus

Pituitary / Hypophysis

Thyroid Parathyroid

Pancreas

Adrenal

Ovary

Testes

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Hypothalamus

(Neuroendocrine)

TRH

GnRH

CRH

GHRH

GHIH (Somatostatin =

SS) ADH / Vasopressin

Oxytocin

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Anterior Pituitary

Adeno-Hypophysis

TSH / TSHs

FSH

LH PRL

GH / Somatotropin

IGF-1

ITT / OGTT

ACTH / Corticotropin

Alfa-MSH

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Posterior Pituitary

Neuro-Hypophysis

ADH / Vasopressin

Osmolality Direct (Measured)

Indirect (Calculated)

Water Deprivation Test

Oxytocin

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Thyroid / Parathyroid

THYROID :

T4 / Thyroxine

T3 / Triidothyronine

fT4

fT3

Calcitonin

PARATHYROID :

PTH

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Pancreas

Islets of Langerhans

Insulin

Glucagon

Somatostatin

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Adrenal Cortex

Mineralocorticoids

Aldosterone Glucocorticoids

Cortisol

Androgens

DHEA

Testosterone

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Adrenal Medulla

Epinephrine

Norepinephrine

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Ovarium

Follicle / Corpus Luteum

Progesterone

Estrogens

Estradiol

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Testes

Androgens

Testosterone

Estradiol

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Analytical Methods

Bioassay

Receptor based Immunoassay

Instrumental

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Preanalytical Factors

Uncontrollable

Controllable

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Preanalytical Factors

Uncontrollable

Biological

Age, Sex, Race

Environmental Altitude, Ambient Temprature, Place of residence

Long-term Cyclical Influences

Seasonal, Mentruation

Underlying Medical Conditions

Obesity, Blindness, Pregnancy, Stress, Fever, Shock

/ Trauma, Transfusion, Infusion

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Preanalytical Factors

Controllable

Physiological variables

Posture, Prolonged bed rest, exercise / physical

training, Circadian variation, Travel

Diet Food ingestion, Ingestion of specific foods and

beverages, Vegetarian, Malnutrition, Fasting /

Starvation

Lifestyle Smoking, Alcohol

Drugs, Herbal, Recreational drugs

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