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DAFTAR ISI
HALAMAN JUDUL ................................................................................................ i
HALAMAN PENGESAHAN ................................................................................. ii
HALAMAN PENGESAHAN ................................................................................. ii
SURAT PERNYATAAN....................................................................................... iii
PERNYATAAN PERSETUJUAN PUBLIKASI KARYA ILMIAH.................... iv
PRAKATA .............................................................................................................. v
DAFTAR ISI ........................................................................................................ viii
DAFTAR GAMBAR ............................................................................................. xi
DAFTAR TABEL ................................................................................................. xii
DAFTAR SINGKATAN ..................................................................................... xiii
INTISARI ............................................................................................................. xiv
BAB I PENDAHULUAN ....................................................................................... 1
1.1. Latar Belakang ................................................................................. 1
1.2. Rumusan Masalah ........................................................................... 4
1.3. Tujuan Penelitan .............................................................................. 4
1.3.1 Tujuan Umum ........................................................................ 4
1.3.2 Tujuan Khusus ....................................................................... 4
1.4. Manfaat Penelitian ........................................................................... 4
1.4.1. Manfaat Teoritis ..................................................................... 4
1.4.2. Manfaat Praktis ...................................................................... 4
BAB II TINJAUAN PUSTAKA ............................................................................. 5
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2.1. Pengertian Pharmacovigilance ........................................................ 5
2.1.1. Tujuan Pharmacovigilance .................................................... 5
2.2. Pengertian Reaksi Obat Yang Tidak Dikehendaki (ROTD) ............ 5
2.3. Pengertian Algoritma Naranjo ......................................................... 6
2.4. Tuberkulosis .................................................................................... 7
2.4.1. Definisi ................................................................................... 7
2.4.2. Epidemiologi .......................................................................... 7
2.4.3. Klasifikasi .............................................................................. 9
2.4.4. Patogenesis ........................................................................... 13
2.4.5. Cara Penularan Tuberkulosis. .............................................. 15
2.4.6. Penatalaksanaan TB ............................................................. 16
2.5. Pengendalian TB ........................................................................... 43
2.6. Rumah Sakit Islam Sultan Agung Semarang ................................ 45
2.7. Kerangka Teori .............................................................................. 47
2.8. Kerangka Konsep .......................................................................... 48
2.9. Hipotesis ........................................................................................ 48
BAB III METODE PENELITIAN........................................................................ 49
3.1. Jenis Penelitian dan Rancangan Penelitian .................................... 49
3.2. Variabel dan Definisi Operasional ................................................ 49
3.2.1 Variabel Bebas dan Terikat .................................................. 49
3.2.2 Definisi Operasional ............................................................ 49
3.3 Populasi dan Sampel ...................................................................... 50
3.3.1 Populasi Penelitian ............................................................... 50
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3.3.2 Sampel Penelitian ................................................................. 50
3.4. Intstrumen Penelitian ..................................................................... 52
3.5. Metode Pengumpulan Data ........................................................... 52
3.6. Cara Penelitian ............................................................................... 53
3.6.1. Perencanaan ......................................................................... 53
3.6.2. Pelaksanaan .......................................................................... 53
3.7. Tempat Dan Waktu Penelitian ....................................................... 55
3.7.1. Tempat Penelitian ................................................................ 55
3.7.2. Waktu Penelitian .................................................................. 55
3.8. Alur Penelitian ............................................................................... 56
3.9. Pengolahan Dan Analisa Data ....................................................... 57
3.9.1. Pengolahan Data .................................................................. 57
3.9.2. Analisis Data ........................................................................ 58
BAB IV HASIL PENELITIAN DAN PEMBAHASAN ..................................... 59
4.1. Hasil Penelitian dan Pembahasan .................................................. 59
4.1.1. Hasil Uji Validitas dan Reliabilitas ...................................... 59
4.1.2. Karakteristik Responden ...................................................... 60
4.2. Pembahasan ................................................................................... 67
BAB V KESIMPULAN DAN SARAN ................................................................ 71
5.1. Kesimpulan .................................................................................... 71
5.2. Saran .............................................................................................. 72
DAFTAR PUSTAKA ........................................................................................... 73
LAMPIRAN
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DAFTAR GAMBAR
Gambar 2.1. Bagan Kerangka Teori ..................................................................... 47
Gambar 2.2. Bagan Kerangka Konsep .................................................................. 48
Gambar 3.1. Bagan Alur Penelitian ...................................................................... 56
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DAFTAR TABEL
Tabel 2.1. OAT Lini Pertama ....................................................................................... 18
Tabel 2.2. Kisaran dosis OAT lini pertama bagi pasien dewasa ................................... 19
Tabel 2.3. OAT yang diguanakan dalam pengobatan TB MDR ................................... 19
Tabel 2.4. Dosis Paduan OAT KDT kategori 1: 2(HRZE)/4(HR)3 .............................. 23
Tabel 2.5. Dosis Paduan OAT Kombipak Kategori 1: 2HRZE/4H3R3 ........................ 24
Tabel 2.6. Dosis Paduan OAT KDT Kategori 2: 2(HRZE)S/(HRZE)/5(HR)3E3 ......... 24
Tabel 2.7. Dosis Paduan OAT Kombipak Kategori 2: 2HRZES/HRZE/5H3R3E3 ...... 25
Tabel 2.8. Acuan penilaian tingkat kegagalan fungsi ginjal pada penyakit ginjal
kronis. .......................................................................................................... 31
Tabel 2.9. Dosis yang dianjurkan pada pengobatan pasien TB dengan penyakit
ginjal kronis ................................................................................................. 31
Tabel 2.10. Efek samping ringan OAT ........................................................................... 35
Tabel 2.11. Efek Samping berat OAT............................................................................. 36
Tabel 3.1. Waktu Penelitian ................................................................................. 55
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DAFTAR SINGKATAN
ADR : Adverse Drug Reaction
BTA : Basil Tahan Asam
DOTS :Directly Observed Treatment Short-course
IRIS : Immune Response Inflammatory Syndrome
ISTC :International Standards for Tuberculosis Care
MDG‟s : Millenium Development Goals
OAT : Obat Anti Tuberkulosis
ROTD : Reaksi Obat Yang Tidak Dikehendaki
TB : Tuberkulosis
WHO : World Health Organization