kelarutan gas dalam darah

8/9/2019 Kelarutan Gas Dalam Darah

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KELARUTAN GAS DALAM

DARAH

ADELINA SIMAMORA, S.Si, MS


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Tujuan Instrusi!na" u#u#

Ma$asis%a &a'at #(#a$a#i )

1. 'rinsi' ("arutan *as &a"a# "i+ui& s(ara -isia&an s(ara i#ia.

2. -at!r -at!r an* #(#'(n*aru$i ("arutan*as &a"a# "i+ui&.

. (ntu (ntu trans'!rt O2 &a"a# &ara$.

. (ntu3(ntu trans'!rt 4O2 &a"a# &ara$.

5. $uu# asi #assa &a"a# ("arutan O2 &an 4O2 &a"a# &ara$.

. (-( &(!#'r(si


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KELARUTAN GAS DALAM

4AIR 6LI7UID8

9 :rinsi' ) like dissolve like ;


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K("arutan s(ara =isia

9 Gas t(r"arut tan'a (r(asi &(n*an

'("arutna.

9K("arutan *as s(ara -isia (i", ar(na'(r(&aan ('!"aran antara *as &an

'("arutna ju*a (i".

4!nt!$ ) ("arutan *as O2, N2, atau H2

&a"a# air.


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K("arutan s(ara Ki#ia

9 Gas t(r"arut (r(asi &(n*an '("arutna,

s($in**a ("arutan *as #(nja&i "(i$ (sar.

4!nt!$ )

4O26a+8 >H2O → H24O0 6a+8 → H>6a+8 > H4O03.

SO26a+8 >H2O → H>6a+8 > HSO03 6a+8

NH06a+8 >H2O → NH> 6a+8 > OH36a+8

4O26a+8 >NaOH6a+8 → Na24O06a+8


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K("arutan s(ara Ki#ia

9 Da"a# r(asi &i atas t(rja&i j(#atan Hi&r!*(n

antara *as 4O2 , SO2, &an NH0 &(n*an air.

9 Misa"na 'a&a *as NH0 &a'at t(rja&i j(#atan

Hi&r!*(n ) O H …N &an N H …O


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K("arutan ((ra'a j(nis *as &a"a# air


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=at!r an* #(#'(n*aru$i ("arutan *as

&a"a# air

1.T(#'(ratur

T ↑, ("arutan *as &a"a# air ↓.

En(r*i in(ti *as ↑ , #!"(u" *as

(r*(ra s(#ain ('at, s$*#u&a$ #(nin**a"an '("arutna.

2.T(anan 6:8: ↑, ("arutan *as &a"a# air ↑


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=at!r an* #(#'(n*aru$i ("arutan *as

&a"a# air

. A&ana


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Huu# H(nr

9 :a&a T t(ta', -rasi #!" *as &a"a# "arutan

(ran&in* "urus &(n*an t(anan )

n C . : n ) #!" *as

N > n 6 Nn8 N ) #!" '("arut

) *t* '& *as '("arut

n / N C . : atau 4 C . :

F(r"au untu *as &(n*an ("arutan (i" s(&iit

atau ti&a (r(asi &(n*an '("arutna.


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Huu# H(nr

9 a&i jia : ↑ nai, ("arutan *as ↑, sa#'ai :

ti&a "a*i #(naian ("arutan *as ar(na

su&a$ #asi#u#.

9 Fi"a &a"a# air "arut * *as, s(tia' *as aan

(rtin&a in&ii&ua" &(n*an t(. *asna a&a"a$

t( 'arsia" *as ts.


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Huu# Da"t!n

9 T(anan t!ta" *as a&a"a$ ju#"a$ t(anan#asin*3#asin* !#'!n(n.

9 T(anan u&ara )

: 6t8 C : O2 > : N2 > : 68

: 6t8 ) t(anan t!ta" u&ara

: O2 ) t(anan !si*(n

: N2 ) t(anan nitr!*(n

: 68 ) t(anan >*as3*as "ain 6J 18


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KELARUTAN GAS

DALAM DARAH

9 Dara$ #(n*an*ut O2 &an 4O2

9 Futir &ara$ #(ra$ #(n*an&un* $(#!*"!in

an* &a'at (r(asi &(n*an O2 .

9 K("arutan O2 &a"a# (ritr!sit &a"a# '"as#a

6> 0 air8

3 :"as#a &ara$ #(n*an&un* *ara# →

$i*r!s!'is s$* #!"(u" air s(#ain s(&iit.3 K("arutan 4O2 &"# '"as#a &r'& &"# air.


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Trans'!rt Osi*(n &a"a# &ara$

9 Di"auan #("a"ui &ua ara )

3 s(ara -isia ) ("arutan O2 s(ara -isi

&a"a# '"as#a &ara$ 61.5 8.3 s(ara i#ia%i ) O2 (r&i-usi &a"a# s("

&ara$ #(ra$ &an t(riat s(ara i#ia%i

'a&a H(#!*"!in [email protected] 8.


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Trans'!rt 4O2 &a"a# &ara$

9 4O2 #(ru'aan $asi" r(s'irasi s("u"ar.

9 Kar(nana &i s(" jarin*an : 4O2 tin**i

an* #(n(aan &i-usi 4O2 ('(#u"u$ &ara$ a'i"(r &an &ian*ut

#("a"ui ti*a ara)

1.s(arafisika

) ("arutan 4O2 &a"a#plasma darah 6?8. K("arutan 4O2 2

a"i "(i$ (sar &ari'a&a ("arutan O2

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2. S(ara i#ia) 4O2 (r&i-usi ( s(" &ara$ #(ra$ &an&iua$ #(nja&i)

a. Carbamino haemoglobin t(riat 'a&aH(#!*"!in 628

9 t(riat 'a&a *u*us a#in! 'a&a tia' ujun* t(r#ina"&ari ( rantai '!"i'('ti&a.

. !on "ikarbona# 6?08H2O > 4O2 H24O H> > H4O3

&i (ritr!sit t(rja&i 10 000 "(i$ ('at &' &i '"as#a

ar(na a&ana (nBi# carbonate anhidrase. i!n

H4O3 #& #su &" '"as#a

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9 I!n H> &in(tra"isir !"($ H 6&aa u--(r

H8 ; HH.

9 Untu #(nja*a (n(tra"an "istri &a"a# s("

&ara$ #(ra$, i!n H4O03 an* ( "uar

#(nuju '"as#a &i*antian !"($ 4"3.

9 Da"a# '"as#a, i!n H4O03 &a'at (rtin&a

s(a*ai u--(r &a"a# #(n*!ntr!" 'H

&ara$.

02/15/15 1?


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H(#!*"!inS(tia' s(" &ara$ #(ra$ #(n*an&un* 250

juta #!"(u" H(#!*"!in.Karat(risti H(#!*"!in)

1. G"!in) t(r&iri &ari rantai '!"i'('ti&a

&(n*an !n-!r#asi ) 2 rantai 6#asin*3#asin* 11 r(si&u8 &an 2 rantai 6#asin*3#asin* 1 r(si&u8.

2. Gu*us H(#() #(n*an&un* I!n =(6II8.H(#( #(n(#'(" 'r!st(ti '& rantai'!"i'('ti&a.


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S(tia' G"!in #(n*an&un* H(#(.

Gu*us H(#( (riatan &(n*an'!"i'('ti&a #("a"ui =(6II8an* t(riat

&(n*an r(si&u Histi&in &ari '!"i'('ti&a.

9 =(6II8 (riatan !!r&inasi &(n*an ua$"i*an.

9 Satu t(#'at !s!n* 'a&a =(6II8 &iisi !"($

#!"(u" O2

9 FM H C 500


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S(tia' #!"(u" H #(n*iat #!"(u"

!si*(n, s(a s(tia' at!# =( #(n*iat

1 #!"(u" O2

Osi$(#!*"!in t(riat s(ara reversibel

H > O2 H.O2

Da"a# (a&aan &i#ana O2 t(riat 'a&a

H ; saturasi 100.

Saturasi H #(n*iuti h$k$m aksi

massa

H &a'at ju*a #(n*iat 4O2, H>, &an 4O


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9 :(n*iatan !si*(n (rsi-at r((rsi(" )

H > O2 H.O2


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9 H #(n*an*ut O2 &ari 'aru3'aru (

jarin*an

9 H #(n*an*ut 4O2 &an H> 6'r!&u a$ir

r(s'irasi8 &ari jarin*an ( 'aru3'aru &an

*inja".

9 H> t(riat 'a&a r(si&u $isti&in 6u--(r H8

'a&a rantai 3*"!in &an 'a&a 2 r(si&u

"ain &i rantai .

9 4O2 t(riat 'a&a *u*us a#in! 'a&a tia'

ujun* t(r#ina" &ari ( rantai '!"i'('ti&a.


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Huu# Asi #assa

9 K(anaan r(asi ti&a t(rja&i s(ara tuntas→ ti&a s(#ua r(atan t(r'aai $ais.

9 R(asi (s(ti#an*an )

r(asi &i#ana '(rua$an t(r$a&a' sist(#t(rja&i s(ara #ir!s!'is. S(ara #ar!s!'is

'(rua$an ti&a t(ra#ati.

A > F → C + D

Pada saat konsentrasi C dan D meningkat, C dan D

dapat bereaksi balik membentuk A dan B (reaksi

balik)


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9 :a&a satu %atu, ( r(asi ( iri aan

sa#a &(n*an r(asi ( ara$ anan →

kesetimbangan.

9 :a&a saat (s(ti#an*an t(ra'ai,

!ns(ntrasi A, F, 4, &an D ti&a (rua$.

9 Ti&a a&a '(rua$an n(tt! !ns(ntrasi A,

F, 4, &an D.


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K!nstanta (s(ti#an*an

9 F(sarna !nstanta (s(ti#an*an#(#'(r"i$atan ara$ r(asi.

9 R(asi &(n*an ni"ai K (sar, aan

(r*(s(r ( anan.9 R(asi &(n*an ni"ai K (i", aan

(r*(s(r ( iri.

9 R(asi &(n*an ni"ai K 1, aan t(r&a'ats(ju#"a$ r(atan &an 'r!&u &a"a#

ju#"a$ si*ni-ian.


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:rinsi' L(4$at("i(r

9 ia sist(# &ina#i &i(ri *an**uan, #aasist(# aan #(#ini#a"an *an**uan t(rs(ut.

aA6*8 > F6*8 46*8 > &D6*8

:4

:D&

C 7 : Aa :F

M(rua$ !ns(ntrasi r(atan &an 'r!&u

ia 'r!&u &ita#a$, (s(ti#an*an aan

(r*(s(r ( iri.ia r(atan &ita#a$, (s(ti#an*an aan

(r*(s(r ( anan.


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:(rna-asan

Transpor# C%&

Sel 'aringan ) a$an aar !r*ani&i!si&asi !"($ #it!!n&ria &(n*an

#(n**unaan O2 an* &ia%a &a"a# H.

9 Hasi" '(#aaran ) 4O2

9 Dian*ut ( 'aru3'aru &a"a# (ntu i!n

H4O03, 4ara#in!3H, &an *as t(r"arut&"# '"as#a.


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Di 'aru3'aru) : 4O2 &ara$ J : 4O2 a"(!"i

s($in**a)

3 4O2 an* t(r"arut sr -isi &a"a# '"as#a

("uar ( a"(!"i. K(stn*an r(asi (riut

(r*(s(r ( iri)

H2O > 4O2 H24O0 H> > H4O03

3 H4O03 &"# '"as#a #asu ( SDM, 4"3

("uar #(nuju '"as#a 6'(r*(s(ran"!ri&a8.

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9 H4O03 (r*aun* &(n*an H> * (rasa"

&ari HH #(#(ntu H24O0

9 H24O0 t(r'(a$ #(nja&i H2O > 4O2

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:(rtuaran Gas &i :aru3'aru

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:(rtuaran *as &i 'aru3'aru

O2 "arut s(ara -isi &a"a# '"as#a 618,

na#un s(a*ian (sar (r&i-usi &a"a#

SDM 628 (r(asi &(n*an &(!siH 68

#(#(ntu !siH 68 sa#i"

#("('asan H> 658.

:& saat H j(nu$ &(n*an O2, a-initas t$&

4O2 s$* 4O2 * t(riat '& H 68 aan

t(r&is!siasi &an (r&i-usi ("uar &ari

SDM 6?8 #("a"ui '"as#a #(nuju a"(!"i.

02/15/15


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I!n H> an* &i"('asan H(#!*"!in

(riatan &(n*an i!n H4O03 6@8 an*

(r&i-usi ( &a"a# SDM &ari '"as#a &an

sa"in* (rtuar t(#'at &(n*an 4"3 68.

R(asi antara H> &an H4O03 #n*$asi"an

H24O06108.

As. Kar!nat '(a$ #(nja&i H2O 4O2 6118

&(n*an antuan (nBi# ar!nat

an$i&ras(. 4O2 (r&i-usi ("uar &ari SDM

6128 #(nuju '"as#a "a"u ( a"(!"i 618

02/15/15


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:(rtuaran Gas &i arin*an


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:(rtuaran *as &i jarin*an

4O2 t(r"arut &a"a# ju#"a$ (i" &a"a#'"as#a 618 na#un s(a*ian (sar(r&i-usi ( &a"a# SDM 628 (r(asi &*air #(#(ntu H24O0 68 atau (riatan

&(n*an H #(#(ntu ara#in!H6118. R(asi &iata"isis !"($ ar!nat(an$i&ras(. T(r&is!siasi j& H> &an H4O03

68

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S("a#a '(r*(s(ran "!ri&a, i!n H4O03 658

(r&i-usi ("uar &ari SDM &i*antian !"($4"3 68. S("anjutna H4O03 (rtin&a s*

u--(r #(n*!ntr!" 'H &ara$.

Da"a# SDM, i!n H>

6?8 &iu--(r !"($ H 6@8.:a&a (a&aan &i#ana H (riatan &* H>

H 'una a-initas an* r(n&a$ t$& O268.

S(ju#"a$ (i" O2 &ian*ut &a"a# (a&aant(r"arut s(ara -isi 6108 (r&i-usi ("uar

&ari '"as#a #asu ( &a"a# s(" jarin*an.

02/15/15 ?


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:(rtuaran *as &ari jarin*an (

'(#u"u$ &ara$ a'i"(r


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:(rtuaran *as &ari '(#u"u$

&ara$ a'i"(r ( jarin*an


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:(rtuaran 4O2 &a"a# &ara$


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E(ek Dekompresi

9 :a&a '(r#uaan "aut :6t8 C 1 at# 6?0##H*8, aitu t(r&iri &ari : O2 C 0.21 at#,: N2 C 0.?@ at#, &an : *as "ain3"ain C 0.01

at#.9 S(tia' turun &ari '(r#uaan u#i 10 #, :

t!ta" nai 1 at# ; !nst.*as nai.

9 F(rna-as 'a&a (&a"a#an "autan ; "(i$ana #!"(u" *as O2 &an N2 an*t(r$isa' 6H. H(nr &an H. Da"t!n8.


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9 Estra #!"(u" O2 &an 4O2 6(32na *as

an* ti&a in(rt8 aan t(r#(ta!"is#(.S($in**a s("a"u aan "(i$ ana 4O2

an* &i("uaran &ari'a&a an* &i$isa'.

S(a"ina untu O2.

9 N2 6*as in(rt8 ti&a t(r#(ta!"is#(. :a&a

'(r#uaan "aut, ju#"a$ N2 an* &i$isa'

&an &i("uaran sa#a. Estra N2 aan

#asu &a"a# &ara$ &an jarin*an t(ta'

&a"a# (ntu *as.


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9 Fi"a nai ( '(r#uaan, : (ruran*, s($in**aN2 aan ("uar &ari jarin*an &a"a# (ntu

*("(#un*2 u&ara.9 ia '(nurunan t(anan t(rja&i san*at ('at,

*("(#un* N2 an* t(r(ntu #(nja&i "(i$(sar.

9 Gas *as ts ti&a !"($ t(r"a"u ('at#(nin**a"an '(#u"u$ &ara$ → #(nu#at'(#u"u$ &ara$ a'i"(r.

9 G("(#un* an* (sar &a"a# jarin*an &ansiru"asi &ara$ aan #(n*aiatan *(ja"a3*(ja"a &ari '(nait &(!#'r(si.


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9 T(rsu#atna a"iran &ara$ ( '(rs(n&ian;sait '(rs(n&ian 6P(n&Q8

9 Su#atan #(n*$a#at su'"ai O2 (

jarin*an. A'ai"a su'"ai O2 ( sist(# sara-(ruran* → -ata" 6("u#'u$an ataustr!(8.

9 M(n(*a$ (#!"i 6t(rsu#atna

'(#u"u$ &ara$ !"($ *("(#un* *as8)nai s(ara '(r"a$an → &(!#'r(si → #(n*("uaran N2.


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K(raunan *as 4O

9 Gas ar!n #!n!si&a 64O8 &an *asasa# siani&a 6H4N8 aan (r!#'(tisi&(n*an O2 untu t(riat 'a&a =( &a"a#

H ar(na (#iri'an strutur (32na&(n*an O2.

9 4O aan t(riat 'a&a H 210 "(i$ uat

&ian&in* O2.9 Ini aan #(n*uran*i '(na#'aian O2 (

jarin*an.


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9 H6a+8 > O26a+8 HO2 6a+8

K6O28 C HO2H:O2

9 H6a+8 > 4O6a+8 H4O 6a+8

K64O8 C H4OH:4O

K64O8 K6O28

an* (rarti 4O t(riat 'a&a H "(i$ uat&ari 'a&a O2


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9 :a&a saat H t(r(s'!s 'a&a 4O &an ,

t(rja&i !#'(tisi &(n*an r(asi )9 HO26a+8 > 4O6a+8 H4O6a+8 >O2 6a+8

Har*a K untu r(asi &i atas )

K C H4O:O2 C K64O8

HO2:4O K6O28

H4O C K :O2

HO2 :4O


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HO26a+8 > 4O6a+8 H4O6a+8 >O2 6a+8

9 u#"a$ r("ati- t(r*antun* 'a&a t(anan'arsia" 4O &an O2. ar(na K64O8 K O2,$ar*a K untu r(asi !#'(tisi 1.

9 :a&a t(#' @!4, ni"ai K C 210, s($in**a'!sisi (s(ti#an*an aan (r*(s(r (anan. 64O #(n**(s(r O2 &ari !#'"(sH4O8.

9:r!s(s ini (rsi-at r((rsi(". F(r&asar'rinsi' L(4$at("i(r, t(anan O2 an* (saraan #(n**(s(r (s(ti#an*an ( iri.


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Good luck

The )hole ar# o( #ea*hing is onl+ #he ar# o( a)akening

#he na#$ral *$riosi#+ o( +o$ng minds

(or #he p$rpose o( sa#is(+ing i# a(#er)ards.,

kelarutan gas dalam darah

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