dasar toksik2 fr

7/25/2019 Dasar Toksik2 Fr

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BASE OF TOXICOLOGY

1. Preface :

Toxicology is st!y a"ot t#e c#aracteristic ofc#e$ical toxi% to&ar! #$a% "ei%ga%! e%'iro%$e%t.

Xe%o"iotic (xe%o ) stra%ge*

C#e$ical : + ,rg

,irectorate of !rg a%!foo! + foo!

s-er'isio%

(PO* /ealt# ,e-t.

A%ot#er c#e$icals :

Arra%ge! "y Fo%!atio% of E%'iro%$e%tal

Protectio% Age%cy i% AS.


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Be%e4t of a%ti!ot$ co%sist of:

+ 5orit

+ Ta%at aci!

+ g O3si!a

6%certai%7 "esi!e t#at co$"i%atio% so$eti$e$tal a%tago%is$e.

A -art of %orit acti'ities !isa--eare! "y go3si!a.

Co%ge%ital !efect

def. Enzim G6PDI5/7-ri$a3i%7 s3si%il3oli%

Hemolysis


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8. Toxicology Ex-eri$e%tal

9 #y-erte%si a%! co%trace-tio%

eect

Carsi%oge%i3 a%! teratoge%ic8.1 P#ar$aco3i%etic Test

eta3oli% a%! 3ar"a3ol

%ee! lo%g ca-acity&as eecti'e7 also toxic

+ Excretio% : origi% a%!$eta"olite

+ Plas$a ca-acity

+ /alf -erio!+ C#aracteristic !istri"tio%

+ Biotra%sfor$atio% a%! excretio% -ro!ct


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8. 8 P#ar$aco!y%a$ic test

8. ; E'alate t#e c#e$ical safety

T#ere are %o eect Le'el (5EL*

5EL : Total co%ce%tratio% i% c#e$ical fo%! oro"ser'atio%7 t#ere are %o !efect7 %o c#a%ge oforga% f%ctio%7 %o c#a%ge of gro&t#.

Safety : 1< x 1

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