vi

DAFTAR ISI

HALAMAN JUDUL ........................................................................................ i

HALAMAN PENGESAHAN ......................................................................... ii

SURAT PERNYATAAN ............................................................................... iii

PRAKATA ...................................................................................................... iv

DAFTAR ISI ................................................................................................... vi

DAFTAR SINGKATAN ................................................................................ ix

DAFTAR TABEL ............................................................................................ x

DAFTAR LAMPIRAN ................................................................................... xi

INTISARI ...................................................................................................... xii

BAB I : PENDAHULUAN ........................................................................... 1

1.1 Latar Belakang ..................................................................................... 1

1.2 Rumusan Masalah ................................................................................ 4

1.3 Tujuan Penelitian ................................................................................. 4

1.4 Manfaat ................................................................................................ 5

BAB II : TINJAUAN PUSTAKA .................................................................. 6

2.1 Pterigium .............................................................................................. 6

2.1.1 Definisi....................................................................................... 6

2.1.2 Derajat Pterigium ....................................................................... 7

2.1.3 Patofiologi .................................................................................. 8

2.1.4 Faktor Risiko.............................................................................. 9

2.2 Rekurensi Pterigium ........................................................................... 10

2.2.1 Definisi..................................................................................... 10

vii

2.2.2 Patofisiologi ............................................................................. 10

2.2.3 Faktor Risiko............................................................................ 11

2.3 Mitomycin C (MMC) ......................................................................... 12

2.4 Autograft ............................................................................................ 13

2.4.1 Definisi..................................................................................... 13

2.4.2 Indikasi..................................................................................... 13

2.4.3 Komplikasi ............................................................................... 14

2.5 Hubungan Kejadian Rekurensi Paska Operasi Pterigium Metode

Autograft Dengan Pemberian MMC 0,04% ....................................... 15

2.6 Kerangka Teori .................................................................................. 17

2.7 Kerangka Konsep ............................................................................... 18

2.8 Hipotesis ............................................................................................. 18

BAB III : METODE PENELITIAN .............................................................. 19

3.1 Jenis Penelitian dan Rancangan Penelitian ........................................ 19

3.2 Variabel dan Definisi Operasional ..................................................... 19

3.3 Populasi dan Sampel .......................................................................... 20

3.3.1 Populasi .................................................................................... 20

3.3.2 Sampel ..................................................................................... 20

3.3.3 Besar sampel ............................................................................ 21

3.4 Instrumen dan Bahan Penelitian ......................................................... 23

3.5 Cara Penelitian ................................................................................... 23

3.5.1 Persiapan Penelitian ................................................................. 23

3.5.2 Pelaksanaan Penelitian ............................................................. 23

3.5.3 Alur Penelitian ......................................................................... 25

viii

3.6 Tempat dan Waktu Penelitian ............................................................ 26

3.7 Analisis Hasil ..................................................................................... 26

BAB IV : HASIL PENELITIAN DAN PEMBAHASAN ............................. 28

4.1. Hasil Penelitian .................................................................................. 28

4.1.1. Karakteristik Sampel Penelitian ............................................... 28

4.1.2. Perbedaan Rekurensi Pterigium Paska Operasi Autograft

dengan Pemberian Mitomycin C 0,04% Dan Tanpa Mitomycin

C 0,04% ................................................................................... 30

4.2. Pembahasan ........................................................................................ 30

BAB V : KESIMPULAN DAN SARAN ..................................................... 34

5.1. Kesimpulan ........................................................................................ 34

5.2. Saran................................................................................................... 34

DAFTAR PUSTAKA .................................................................................... 36

LAMPIRAN .................................................................................................... 39

ix

DAFTAR SINGKATAN

CCNS : Cell Cycle Non Spesific

CRA-MMC : Conjunctival Rotational Autograft - Mitomycin C

DNA : Deoxyribonucleic Acid

LCAU : Limbal Conjunctival Autograft

MMC : Mitomycin C

RNA : Ribonucleic Acid

RSCM : Rumah Sakit Cipto Mangunkusumo

UV : Ultra Violet

VEGF : Vascular Endothelial Growth Factor

x

DAFTAR TABEL

Tabel 4. 1 Karakteristik pasien pterigium paska operasi autograft terhadap

rekurensi pterigium ............................................................................. 29

Tabel 4. 2 Tabulasi silang antara pemberian Mitomycin C 0,04% dengan

tanpa Mitomycin C 0,04% pada kejadian rekurensi pterigium ........... 30

xi

DAFTAR LAMPIRAN

Lampiran 1 Data Pasien Pterigium Paska Operasi Autograft Periode 2014 -

2016 di Rumah Sakit Islam Sultan Agung Semarang .................... 39

Lampiran 2 Karakteristik Usia Terhadap Rekurensi Pterigium Paska Operasi

Autograft Periode Tahun 2014-2016 di Rumah Sakit Islam

Sultan Agung Semarang ................................................................. 42

Lampiran 3 Karakteristik Jenis Kelamin Terhadap Rekurensi Pterigium

Paska Operasi Autograft Periode Tahun 2014-2016 di Rumah

Sakit Islam Sultan Agung Semarang .............................................. 44

Lampiran 4 Karakteristik Jenis Pekerjaan Terhadap Rekurensi Pterigium

Paska Operasi Autograft Periode Tahun 2014-2016 Rumah

Islam Sultan Agung Semarang ....................................................... 46

Lampiran 5 Perbedaan Rekurensi Pterigium Paska Operasi Autograft dengan

Pemberian Mitomycin C 0,04% Dan Tanpa Mitomycin C

0,04% Periode Tahun 2014-2016 Rumah Islam Sultan Agung

Semarang ........................................................................................ 48

Lampiran 6 Ethical Clearance ........................................................................... 50

Lampiran 7 Surat Izin Pengambilan Data di Bagian Rekam Medis RSI

Sultan Agung Semarang ................................................................. 51

Lampiran 8 Surat Selesai Penelitian di Bagian Rekam Medis RSI Sultan

Agung Semarang ............................................................................ 52

Lampiran 9 Dokumentasi Penelitian di Bagian Rekam Medis RSI Sultan

Agung Semarang ............................................................................ 53