2. parkinson pendahuluan
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8/17/2019 2. PARKINSON Pendahuluan
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PARKINSON( Pendahuluan)
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• PARKINSONISMSindroma : tremor waktu istirahat, rigiditas, bradikinesia, dan
hilangnya refleks ostural !!!!! "RAP
Sindroma Parkinson
• P#N$AKI" PARKINSON
Penyakit
% k l i n i s : tremor waktu istirahat, rigiditas, bradikinesia,dan hilangnya refleks ostural
% patologis : degenerasi neuron%neuron bergigmen neuromelanin, terutama di ars komakta substansia nigra,
yang disertai adanya inklusi sitolasmik eosinofilik
(Lewy bodies)
Parkinsonisme idiopatik atau primer
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Klasifkasi Parkinsonism
& Primer (idiopatik) : Penyakit Parkinson
& Sekunder (simptomatik)
& Drug induced& Ineksi (postensealitis, siflis)
& eta!olik
& Struktural (tumor otak, hydrosealus,
trauma)
& "oksin ( #O, #S$, #N, an%an, P"P)
& &askular (multiinark)
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Klasifkasi Parkinsonism
& Sindroma Parkinsonism'plus ' e%enerasi kortio'!asal %an%lioni
' *emiparkinsonism'hemioatrof
' Syndroma dementia: Penyakit Al+heimer,iuse -e.y !ody disease
' Atrof multipel'system
' Parkinsonism'dementia'A-S omple/ o 0uam
(-ytio'!odi%) ' Pro%ressi1e supranulear palsy
' Penyakit herediter de%enerati
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Penyakit Parkinson (P)
& Salah satu 2enis parkinsonism yan%
penye!a!nya idiopatik
& seara patolo%is ditandai den%ande%enerasi neuron !erpi%men
neuromelamin di pars kompakta
su!stansia Ni%ra yan% disertai adanya-e.i !odies
& ise!ut 2u%a Parkinson Primer
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P
& 3ames Parkinson 4546 memakai
istilah 7shakin% palsy8
& Penyakit Parkinson (P): tremor,
ri%iditas, !radikinesia,
ketidaksta!ilan postur dan %ait
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P
Insiden
& 9,'$4; 4
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ParkinsonDs isease RiskEators
& Defnite: Old a%e
& Probable: Positi1e amily history
& Possible: *er!iides, pestiides, hea1y
metals, pro/imity to industry, ruralresidene, .ell .ater, repeated headtrauma, et=
& Possible protective eect: Smokin%
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Prelinial ParkinsonDsisease
& No speif linial markers kno.n
& 9'4@ o autopsies in elderly sho.in%inidental -e.y !odies are re%arded as
prelinial ases& Inreased risk o neurolepti parkinsonism
& uration o prelinial phase unkno.n
(se1eral years to se1eral deadesF)& PG" studies may identiy prelinial ases
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Garly Si%ns and Symptoms
#ardinal#harateristis
& Restin% tremor
H radykinesia& Ri%idity
& Postural insta!ility
Other& iro%raphia
& asked ae
& Slo.in% o A-S& Stooped, shuJin%%ait
& ereased arm
s.in% .hen.alkin%
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#riteria or ia%nosis
& At least t.o o three: rest tremor,!radykinesia, ri%idity
& A!sene o a seondary ause'dru%s,
meta!oli, et=& efniti1e dia%nosis an only !e made !y
autopsy
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"reatment Options
& Pre1enti1e treatment ' No defniti1e treatment a1aila!le
& Symptomati treatment
' Pharmaolo%ial ' Sur%ial
& Non'motor mana%ement
& Restorati1e'e/perimental only
' "ransplantation ' Neurotrophi ators
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