kuliah hormon tiroid.pptx

7/25/2019 kuliah hormon tiroid.pptx

1/22

KELENJAR TIROID

&

HORMON TIROID

M. Luthfi, dr., SpPD.


2/22

Kelenjr Tir!id

Tir!id Th"re!# $"unni% peri#i, eid!#

'entu(%

Kelenjr end!(rin ter'e#r pd de)#

*entu( #eperti (upu+(upu Terdiri dri l!'u# "n- dihu'un-(n !leh

i#thu#.

Terlet( di nteri!r tr(e ntr tuln-

r)n (ri(!id. *ert n!rl /+0 -, #n-t 1#(ulr,

(!n#i#ten#i lun(.


3/22


4/22

Hi#t!l!-i Kelenjr Tir!id

Kelenjr tir!id terdiri dri

f!li(el 'er'entu( '!l

"n- u(urnn"'er1ri#i.

Setip f!li(el dilpi#i #el

epitel (u'!id $epitel

f!li(el% "n- en-elilin-iluen (!l!id.


5/22

http22r'l.31'#.3!l!#tte.edu2h'!!(#2pthph"#2end!3rine2th"r!id2nt!".htl

TH4ROID 5LAND HISTOLO54


6/22

6!li(el Tir!id

6!li(el dlh unit #e(re#i fun-#i!nl #el+

#el (elenjr tir!id.

Sel 6!li(ulr en-h#il(n 3irn (!l!id

"n- (entl dn en-ndun-.

K!l!id terdiri terut dri tir!-l!'ulin $T-%

Th"r!-l!'ulin -li(!pr!tein den-n *M

tin--i 'erpern dl pe'entu(n

h!r!n tir!id dl luen f!li(el tir!id.


7/22

O OH

I

I

II

OH

O

NH

Th"r!7ine $T8%

O OH

I

I

I

OH

O

NH

9,:,9;+Trii!d!th"r!nine $T9%

TH4ROID HORMONES


8/22

Sinte#i# H!r!n Tir!id

Ln-(h pert dl #inte#i# h!r!n tir!id

dlh "!diu !r-nifi3ti!n.

I!did di'il, di(!n1er#i (e "!diu, dn

(eudin ter(!nden##i (e re#idu tir!#in "n-

'erd di #epnjn- !le(ul p!lipeptid pr!tein"n- di#e'ut th"r!-l!'ulin.

H#il re(#i ini dlh tir!#in !n!+i!din#i $MIT%

tu di+i!din#i tir!#in $Dit%.

I!d!th"r!-l!'ulin "n- ter'entu( erup(n #lh

#tu un#ur plin- pentin- dri 'hn (!l!id "n-terdpt dl unit f!li(el tir!id.


9/22

Re(#i #inte#i# linn", dlh re(#i (!plin-, di

n !le(ul i!d!t"r!#ine "n- di-'un-(n

'er#+#.

Ji( du !le(ul di+i!d!t"r!#ine 'erp#n-n

'er#+#, h#iln" dlh pe'entu(n

tir!(#in $T8%.

Ji( di+i!d!t"r!#ine dn !n!+i!d!t"r!#ine "n-

di-'un-(n 'er#+#, h#iln" dlh

pe'entu(n tri+i!d!th"r!nine $T9%.


10/22

I < t"r!#ine !n!i!d!t"r!#ine $MIT% MIT < I dii!d!t"r!#ine $DIT%

DIT < DIT th"r!7ine $T8%

DIT < MIT trii!d!th"r!nine $T9%


11/22


12/22

Re-ul#i dn Se(re#i H!r!n Tir!id


13/22

6EED*A>K RE5?LATION

H!r!n "n- 'er#l dri hip!fi#i# "n- en-tur #inte#i# dn

2 tu #e(re#i h!r!n lin di(enl #e'-i h!r!n tr!pi(.

H!r!n ut "n- 'erpern pd (elenjr tir!id

TRH + Th"r!phin Rele#in- H!r!ne

TSH + Th"r!id Stiultin- H!r!ne

T82T9+ Th"r!id h!r!ne#

PIT?ITAR4+TH4ROID A@IS


14/22


Se(re#i h!r!n tir!id ditur

!leh TSH $Th"r!id+#tiultin-

h!r!ne%, "n- en-i(tre#ept!r pd peru(n

'#!lterl #el f!li(el

re'#!rp#i T- dri luen

f!li(el dn pr!te!li#i# dl

#el untu( en-h#il(nh!r!n tir!iddi#e(re#i(n

(e lirn drh.


15/22


Th"r!id h!r!n $T8 dn T9% (n

e'eri(n upn 'li( untu(

en-h't pr!du(#i hip!tlu#

Th"r!tr!pin+rele#in- h!r!ne$TRH% dn pr!du(#i hip!fi#i# th"r!id+

#tiultin- h!r!ne $TSH%.

TSH ern-#n- (elenjr tir!id

untu( epr!du(#i h!r!n T8 dn

T9.


16/22

H"p!thli3+Pituitr"+Th"r!id A7i#

Ne-ti1e 6eed'3( Me3hni#


17/22


18/22


19/22

TSH TSH di#e(re#i(n !leh #el+#el th"r!tr!pe dri

hip!fi#i# nteri!r

'erpern pentin- dl en-endli(n 7i# tir!id

dn 'erfun-#i #e'-i pennd fi#i!l!-i# "n-plin- 'er-un dri h!r!n tir!id.

(dr tertin--i pd l hri.

)(tu pruh pl# reltif pnjn- $:0 enit%.

di-un(n untu( di-n!#i# hipertir!idi#e $TSH

rendh% #ert hip!tir!idi#e $TSH tin--i%.


20/22

TSH

Penin-(tn (dr TSH en"e''(n

Se(re#i h!r!n tir!id T9 dn T8 Penin-(tn (e3eptn I!dine upt(e

Penin-(tn #inte#i# !r!n tir!id

Pen'hn julh dn u(urn f!li(el

tir!id


21/22


22/22

Pen-ruh H!r!n Tir!id pd

'er'-i !r-n

Jntun- t(i(rdi, en-urn-i (e(utn

(!ntr(#i

Pe'uluh drh 1#!(!n#tri(#i

5IT enin-(t(n !tilit# dn '#!rp#i

Si#ti #(eletl enin-(t(n '!ne turn!1er

Neur!u#(uler hiper(tifit#, enin-(t(n

(!ntr(#i !t!t

kuliah hormon tiroid.pptx

Documents