lampiran 1. data hasil pengamatan perubahan fluktuasi ...etheses.uin-malang.ac.id/577/11/09620003...
Post on 10-Feb-2021
17 Views
Preview:
TRANSCRIPT
-
86
Lampiran 1. Data Hasil Pengamatan Perubahan Fluktuasi Berat Badan
Mencit (Mus musculus L) Selama Perlakuan
Perlakuan Minggu
ke- Ulangan Perubahan BB Total Rata2
K- 1 U-1 2 8 2
1 U-2 3
1 U-3 1
1 U-4 2
2 U-1 2 7 2
2 U-2 1
2 U-3 2
2 U-4 2
3 U-1 2 6 2
3 U-2 2
3 U-3 1
3 U-4 1
4 U-1 -1 2 1
4 U-2 2
4 U-3 0
4 U-4 1
5 U-1 -1 -4 -1
5 U-2 -1
5 U-3 -1
5 U-4 -1
6 U-1 -1 -6 -2
6 U-2 -1
6 U-3 -2
6 U-4 -2
7 U-1 0 8 2
7 U-2 3
7 U-3 3
7 U-4 2
8 U-1 3 5 1
8 U-2 0
8 U-3 0
8 U-4 2
9 U-1 2 6 2
9 U-2 2
9 U-3 1
9 U-4 1
10 U-1 -1 -4 -1
10 U-2 -4
10 U-3 0
10 U-4 1
-
87
K+ 1 U-1 1 5 1
1 U-2 2
1 U-3 1
1 U-4 1
2 U-1 3 5 1
2 U-2 1
2 U-3 -1
2 U-4 2
3 U-1 0 2 1
3 U-2 1
3 U-3 0
3 U-4 1
4 U-1 2 7 2
4 U-2 2
4 U-3 0
4 U-4 3
5 U-1 4 6 2
5 U-2 2
5 U-3 3
5 U-4 -3
6 U-1 -1 -1 0
6 U-2 1
6 U-3 -1
6 U-4 0
7 U-1 -3 -6 -2
7 U-2 -3
7 U-3 1
7 U-4 -1
8 U-1 2 8 2
8 U-2 3
8 U-3 1
8 U-4 2
9 U-1 1 0 0
9 U-2 0
9 U-3 -
9 U-4 -1
10 U-1 -1 -1 0
10 U-2 0
10 U-3 -
10 U-4 0
P1 1 U-1 1 6 2
1 U-2 2
1 U-3 2
1 U-4 1
-
88
2 U-1 -1 6 2
2 U-2 3
2 U-3 3
2 U-4 1
3 U-1 1 5 1
3 U-2 1
3 U-3 2
3 U-4 1
4 U-1 0 2 1
4 U-2 2
4 U-3 0
4 U-4 0
5 U-1 1 -2 -1
5 U-2 0
5 U-3 -1
5 U-4 -2
6 U-1 -1 -2 -1
6 U-2 0
6 U-3 0
6 U-4 -1
7 U-1 0 -13 -3
7 U-2 -4
7 U-3 -4
7 U-4 -5
8 U-1 2 16 4
8 U-2 3
8 U-3 5
8 U-4 6
9 U-1 0 -1 0
9 U-2 1
9 U-3 0
9 U-4 -2
10 U-1 0 1 0
10 U-2 2
10 U-3 -1
10 U-4 -
P2 1 U-1 2 10 3
1 U-2 3
1 U-3 4
1 U-4 1
2 U-1 3 8 2
2 U-2 -1
2 U-3 1
2 U-4 5
-
89
3 U-1 3 12 3
3 U-2 6
3 U-3 1
3 U-4 2
4 U-1 1 5 1
4 U-2 -5
4 U-3 7
4 U-4 2
5 U-1 -1 2 1
5 U-2 0
5 U-3 1
5 U-4 2
6 U-1 1 1 0
6 U-2 0
6 U-3 1
6 U-4 -1
7 U-1 -3 -3 -1
7 U-2 1
7 U-3 -1
7 U-4 0
8 U-1 2 4 1
8 U-2 0
8 U-3 1
8 U-4 1
9 U-1 0 -2 -1
9 U-2 -1
9 U-3 0
9 U-4 -1
10 U-1 -1 -2 -1
10 U-2 -1
10 U-3 -1
10 U-4 1
P3 1 U-1 -1 6 2
1 U-2 2
1 U-3 2
1 U-4 3
2 U-1 -3 5 1
2 U-2 0
2 U-3 4
2 U-4 4
3 U-1 1 4 1
3 U-2 0
3 U-3 2
3 U-4 1
-
90
4 U-1 0 2 1
4 U-2 4
4 U-3 -2
4 U-4 0
5 U-1 -1 -1 0
5 U-2 -3
5 U-3 2
5 U-4 1
6 U-1 4 5 1
6 U-2 1
6 U-3 0
6 U-4 0
7 U-1 -2 -4 -1
7 U-2 -2
7 U-3 0
7 U-4 0
8 U-1 -2 -2 -1
8 U-2 0
8 U-3 0
8 U-4 0
9 U-1 1 2 1
9 U-2 1
9 U-3 0
9 U-4 0
10 U-1 -2 -6 -2
10 U-2 -1
10 U-3 -3
10 U-4 0
-
91
Lampiran 2. Data Hasil Pengamatan Histologi Kelenjar Mammae Mencit
(Mus musculus)
1. Rata-rata Diameter Lumen Duktus Mammae Mencit
Perlakuan Ulangan Ke-
Total Rata-rata 1 2 3 4
K- 29,38 28,46 25,54 25,14 108,52 27,13
K+ 15,24 16,46 - 19,05 50,75 16,92
P1 20,60 25,29 19,67 - 65,56 21,85
P2 23,39 24,86 25,81 24,82 98,88 24,72
P3 28,42 24,06 25,47 28,47 106,42 26,61
2. Rata-rata Tebal Epitel Duktus Mammae Mencit
Perlakuan Ulangan Ke-
Total Rata-rata 1 2 3 4
K- 9,30 9,42 10,82 9,71 39,25 9,81
K+ 13,86 17,04 - 14,49 45,39 15,13
P1 11,77 14,06 13,80 - 39,63 13,21
P2 12,27 10,42 9,47 9,88 42,04 10,51
P3 9,95 7,82 10,35 10,24 38,36 9,59
3. Rata-rata Lumen Alveoli Mammae Mencit
Perlakuan Ulangan Ke-
Total Rata-rata 1 2 3 4
K- 26,87 26,25 28,66 27,14 108,92 27,23
K+ 15,33 16,43 - 16,55 48,31 16,10
P1 19,52 18,03 17,98 - 55,53 18,51
P2 24,81 26,30 25,62 24,11 100,84 25,21
P3 25,41 26,68 27,29 27,34 106,72 26,68
-
92
4. Rata-rata Tebal Epitel Alveoli Mammae Mencit
Perlakuan Ulangan Ke-
Total Rata-rata 1 2 3 4
K- 9,10 11,60 7,14 8,03 35,87 8,97
K+ 15,89 13,64 - 16,55 46,08 15,36
P1 9,30 13,01 15,40 - 37,71 12,57
P2 11,47 10,26 9,55 12,38 43,66 10,92
P3 9,72 9,16 9,77 8,36 37,01 9,25
-
93
Lampiran 3. Ciri Fisik Mencit Selama Perlakuan
Minggu
ke- Perlakuan
Perlakuan
K- K+ P1 P2 P3 P4
1
1 N N N N N N
2 N N N N N N
3 N N N N N N
4 N N N N N N
2
1 N N N N N N
2 N N N N N N
3 N N N N N N
4 N N N N N N
3
1 N N N N N N
2 N N N N N N
3 N N N N N N
4 N N N N N N
4
1 N N N N N N
2 N N N N N N
3 N N N N N N
4 N N N N N N
5
1 N N N N N N
2 N N N N N N
3 N N N N N N
4 N N Ps N N N
6
1 N Apcv Apcv N Apcv Apcv
2 N Apcv Apcv
+Apcd Apcv Apcv Apcd
3 N Apcv Apcv
+Apcd Apcv Apcv Apcv
4 N Apcv Apcv
+Ps Apcv Apcv Apcv
7
1 N Apcv Apcv Apcv Apcv Apcv
2 N Apcv Apcv Apcv Apcv Apcd
3 N Apcv
+Asc Apcv Apcv Apcv Apcv
4 N Apcv Apcv Apcv Apcv Apcv
8
1 N Apn Apn Apn Apn Apn
2 N Apn Apn Apn Apn Apn
3 N M Apn Apn Apn Apn
4 N Apn Apcv
+Ps Apn Apn Apn
9
1 N Apn Apn Apn Apn Apn
2 N Apn Apn Apn Apn Apn
3 N M Apn Apn Apn Apn
4 N Apn M Apn Apn Apn
10
1 N Apn Apn Apn Apn M
2 N Apn Apn Apn Apn M
3 N M Apn Apn Apn M
4 N Apn M Apn Apn M
Keterangan: N: Normal, Asc: Ascites (Perut buncit), Alopecia (Kerontokan bulu); Apcv (Alopecia
cephalo ventral): kerontokan bulu bagian ventral kepala, Apcd (Alopecia cephalo
dorsal): kerontokan bulu bagian dorsal kepala, Apn (Alopecia normal): membaik, Ps:
Paralisis (Lumpuh), M: mati.
-
94
Lampiran 4. Perhitungan SPSS ANOVA dan Uji Duncan
1. Pengaruh Ekstrak Daun Sirsak (Annona muricata L.) dan DMBA Terhadap
Fluktuasi Berat Badan Mencit (Mus musculus)
a. Uji Normalitas
One-Sample Kolmogorov-Smirnov Test
Perlakuan FluktuasiBB Minggu
N 160 157 160
Normal Parametersa Mean 2.51 .57 5.50
Std. Deviation 1.122 2.017 2.881
Most Extreme Differences Absolute .176 .135 .107
Positive .168 .135 .107
Negative -.176 -.128 -.107
Kolmogorov-Smirnov Z 2.231 1.688 1.356
Asymp. Sig. (2-tailed) .000 .007 .051
a. Test distribution is Normal.
b. Uji Homogenitas
Test of Homogeneity of Variances
FluktuasiBB
Levene Statistic df1 df2 Sig.
.338 3 153 .798
c. Uji Anova
ANOVA
FluktuasiBB
Sum of Squares df Mean Square F Sig.
Between Groups 8.235 3 2.745 .671 .571
Within Groups 626.313 153 4.094
Total 634.548 156
-
95
2. Pengaruh Ekstrak Daun Sirsak (Annona muricata L.) dan DMBA Terhadap
Tebal Epitel Duktus Mammae Mencit (Mus musculus)
a. Uji Normalitas
One-Sample Kolmogorov-Smirnov Test
Perlak Rata2
N 14 14
Normal Parametersa Mean 2.64 11.8157
Std. Deviation 1.151 2.52803
Most Extreme Differences Absolute .193 .210
Positive .140 .210
Negative -.193 -.141
Kolmogorov-Smirnov Z .723 .784
Asymp. Sig. (2-tailed) .672 .570
a. Test distribution is Normal.
b. Uji Homogenitas
Test of Homogeneity of Variances
Rata2
Levene Statistic df1 df2 Sig.
.294 3 10 .829
c. Uji Anova
ANOVA
Rata2
Sum of Squares df Mean Square F Sig.
Between Groups 65.420 3 21.807 12.347 .001
Within Groups 17.662 10 1.766
Total 83.082 13
-
96
d. Uji Duncan
Rata2
Duncan
Perlak N
Subset for alpha = 0.01
1 2 3
P3 4 9.5900
P2 4 10.5100 10.5100
P1 3 13.2100 13.2100
K+ 3 15.1300
Sig. .386 .024 .088
Means for groups in homogeneous subsets are displayed.
-
97
3. Pengaruh Ekstrak Daun Sirsak (Annona muricata L.) dan DMBA Terhadap
Diameter Lumen Duktus Mammae Mencit (Mus musculus)
a. Uji Normalitas
One-Sample Kolmogorov-Smirnov Test
Perlak Rata2
N 14 14
Normal Parametersa Mean 2.64 22.9721
Std. Deviation 1.151 4.13257
Most Extreme Differences Absolute .193 .183
Positive .140 .103
Negative -.193 -.183
Kolmogorov-Smirnov Z .723 .685
Asymp. Sig. (2-tailed) .672 .736
a. Test distribution is Normal.
b. Uji Homogenitas
Test of Homogeneity of Variances
Rata2
Levene Statistic df1 df2 Sig.
2.804 3 10 .094
c. Uji Anova
ANOVA
Rata2
Sum of Squares df Mean Square F Sig.
Between Groups 178.772 3 59.591 13.780 .001
Within Groups 43.244 10 4.324
Total 222.016 13
-
98
d. Uji Duncan
Rata2
Duncan
Perlak N
Subset for alpha = 0.01
1 2
K+ 3 16.9167
P1 3 21.8533 21.8533
P2 4 24.7200
P3 4 26.6050
Sig. .011 .017
Means for groups in homogeneous subsets are
displayed.
-
99
4. Pengaruh Ekstrak Daun Sirsak (Annona muricata L.) dan DMBA Terhadap
Tebal Epitel Alveoli Mammae Mencit (Mus musculus)
a. Uji Normalitas
One-Sample Kolmogorov-Smirnov Test
Perlak Rata2
N 14 14
Normal Parametersa Mean 2.64 11.7471
Std. Deviation 1.151 2.75180
Most Extreme Differences Absolute .193 .206
Positive .140 .206
Negative -.193 -.122
Kolmogorov-Smirnov Z .723 .769
Asymp. Sig. (2-tailed) .672 .595
a. Test distribution is Normal.
b. Uji Homogenitas
Test of Homogeneity of Variances
Rata2
Levene Statistic df1 df2 Sig.
2.625 3 10 .108
c. Uji Anova
ANOVA
Rata2
Sum of Squares df Mean Square F Sig.
Between Groups 68.852 3 22.951 7.757 .006
Within Groups 29.589 10 2.959
Total 98.441 13
-
100
d. Uji Duncan
Rata2
Duncan
Perlak N
Subset for alpha = 0.01
1 2
P3 4 9.2525
P2 4 10.9150
P1 3 12.5700 12.5700
K+ 3 15.3600
Sig. .036 .060
Means for groups in homogeneous subsets are
displayed.
-
101
5. Pengaruh Ekstrak Daun Sirsak (Annona muricata L.) dan DMBA Terhadap
Diameter Lumen Alveoli Mammae Mencit (Mus musculus)
a. Uji Normalitas
One-Sample Kolmogorov-Smirnov Test
Perlak Rata2
N 14 14
Normal Parametersa Mean 2.64 22.2429
Std. Deviation 1.151 4.61132
Most Extreme Differences Absolute .193 .229
Positive .140 .177
Negative -.193 -.229
Kolmogorov-Smirnov Z .723 .856
Asymp. Sig. (2-tailed) .672 .457
a. Test distribution is Normal.
b. Uji Homogenitas
Test of Homogeneity of Variances
Rata2
Levene Statistic df1 df2 Sig.
.206 3 10 .890
c. Uji Anova
ANOVA
Rata2
Sum of Squares df Mean Square F Sig.
Between Groups 268.853 3 89.618 118.190 .000
Within Groups 7.582 10 .758
Total 276.435 13
-
102
d. Uji Duncan
Rata2
Duncan
Perlak N
Subset for alpha = 0.01
1 2 3
K+ 3 16.1033
P1 3 18.5100
P2 4 25.2100
P3 4 26.6800
Sig. 1.000 1.000 .052
Means for groups in homogeneous subsets are displayed.
-
103
Lampiran 5. Peta Konsep Penelitian
Aktivator P53
Sel Kanker
Acetogenins
Produksi ATP turun
difusi
NADH dehidrogenase
Mitokondria
ATP
ATP yang berada di dinding mitokondria
Sel kanker kekurangan Energi
Sel Kanker Mati
Sel normal
Mengaktifkan p53
-
104
Lampiran 6. Gambar Morfologi Mencit
Gambar 1. Kerontokan bulu bagian kepala dorsal
Gambar 2. Kebotakan bagian kepala dorsal
-
105
Gambar 3. Kerontokan Bulu Bagian Kepala ventral
Gambar 4. Kerontokan Bulu Bagian Kepala Ventral yang disertai kelumpuhan
-
106
Gambar 5. Kelumpuhan
-
107
Lampiran 7. Kegiatan Penelitian
Gambar 1. Alat yang digunakan dalam pembuatan ekstrak
Gambar 2. Penimbahan Hewan coba
-
108
Gambar 3. Pencekokan Ekstrak Daun Sirsak (Annona muricata L.)
Gambar 4. Persiapan Pembedahan
-
109
Gambar 5. Penandaan Area Mammae sebelum Pembedahan
Gambar 6. Organ Mencit dalam proses pembedahan
-
110
-
111
top related