CaL-Threonate+Optimizing the health of your bones

L-1-3 Block L, Pusat Komersil Parklane,No. 21 Jalan SS7/26, Kelana Jaya

47301 Petaling Jaya, Selangor Darul Ehsan, MalaysiaTel: +603 7887 3223 Email: general@haleup.com

www.haleup.com

NU WEALTH MARKETING(1147155 - H)

+6013 206 3218 CaL-Threonate Plus

References:

Utarwuthipong, T, Komindr, S, PAkpeankitvatana, V, Songchisomboon, S & Thongmuang, N. 2009. Small dense low-density lipoprotein concentration and oxidative susceptibility changes after consumption of soybean oil, rice bran oil, palm oil and mixed rice bran/palm oil in hypercholesterolemic women. Journal of Inter. Med. Research. 37: 96-104.

Hu, FB, Stampfer, MJ, Rimm, EB, Manson, JE, Rimm, E, Colditz, GA, Rosner, BA, Hennekens, CH & Willet, WC. 1997. Dietary fat intake and the risk of coronary heart disease in women. The New Eng. J Med. 337(21): 1491-1499. Morton DJ, Barrett-Connor EL, Schneider DL. Vitamin C supplements use and bone mineral density in postmenopausal women. J Bone Miner Res 2001; 16: 135–40.

Hall SL, Greendale GA. The relation of dietary vitamin C intake to bone mineral density: results from the PEPI study. Calcif Tissue Int 1998; 63: 183–9.

Franceschi RT, Lyer BS. Relationship between collagen synthesis and expression of the osteoblast phenotype in MC3T3-E1 cells. J Bone Miner Res 1992; 7: 235–46.

Franceschi RT, Lyer BS, Cui Y. Effects of ascorbic acid on collagen matrix formation and osteoblast differentiation in murine MC3T3-E1 cells. J Bone Miner Res 1994; 9: 843–54.

He JH, Tong NW, Li HQ, Wu J. Effects of L-threonate on bone resorption by osteoclasts in vitro. J Sichuan Univ (Med Sc Edi) 2005; 36: 225–8.

Wang HY, Jiang J, Hu P. Determination of L-threonate in human plasma and urine by high performance liquid chromatography-tandem mass spectrometry. J Chromatogr B 2006; 834: 155–62.

Bello, AE & Oesser S. 2006. Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of the literature. Curr. Med. Research Opin. 22(11): 2221-2232.

Clark, KL, Sebastianelli, W, Flechsenhar, KR, Aukermann, DF, Meza, F, Millard, RL, Deitch, JR, Sherbondy, PS & Albert, A. 2008. 24-week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Curr. Med. Research Opin. 24(5): 1485-1496.

Pada tempoh ini juga, tulang belakang T9 saya turut berkecai dan dalam keadaan di mana saya tidak mempunyai pilihan lain, saya sekali lagi diusung ke dalam bilik pembedahan. Selepas pembedahan yang kedua, saya hanya berbaring diatas katil selama empat tahun dan pembuangan air kecil and besar hanyalah bergantung kepada pemakaian lampin. Saya berasa amat sedih.

Pada tahun 2015, anak kedua saya Andy mengesyorkan saya untuk menukar pengambilan kalsium biasa kepada CaL-Threonate+, dan saya pun mula mengambil satu biji setia pagi and malam.

Selepas 3 bulan, saya mampu bangun dan duduk sendiri dan terasa akan tulang saya kuat bertenaga. Saya pun memulakan rawatan fisioterapi dan menyambung pengambilan CaL-Threonate+. Enam bulan kemudian, saya mampu berjalan tanpa bantuan “walking frame”.

CaL-Threonate+

Ketika saya berumur 80 tahun pada

tahun 2011, dengan tidak sengaja saya telah

menyebabkan tulang belakang T12 saya berkecai.

Setelah menghabiskan banyak wang untuk

menjalani pembedahan pemasangan skru besi, saya hanya mampu baring diatas

katil tanpa bergerak berbulan lamanya dalam kesakitan.

Testimony When I was 80 years of age in 2011, my T12 spinal cord collapsed. Even after spending a lot of money money on a “locking screw-plate fixation” surgery, I was immobilized for month and was only able to lie down, all the while suffering in pain.

During this period of time, my T9 spinal cord also collapsed and given no choice, I had to perform a second operation. Even after the second operation, I was bed-bound for four year. During this time, I had to depend on diapers for my daily motions and emotionally, I was very demotivated.

In 2015, my second son Andy suggested that I replace my regular calcium pills with CaL-Threonate+, and I began to take two tablets daily.

After 3 months, I was able to sit up on my own and began to feel that my bones became stronger. I started physiotherapy and continued with the intake of CaL-Threonate+, and six months later, I was able to walk on my own even without a walking frame to hold on to.

CaL-Threonate+ is a perfect blend of calcium L-threonate, hydrolysed collagen & γ-oryzanol for:

What is Calcium L-threonate?Calcium L-threonate is a compound designed for the treatment of bone disease. L-threonic acid is an active metabolite of vitamin C which had been shown to have an ability in enhancing the bioavailability of minerals, such as calcium. It is well known that vitamin C is a marker for osteoblast formation and has been shown to stimulate procallagen and enhance collagen synthesis (Morton et al. 2001; Hall et al. 1998; Franceschi & Lyer 1992).

How can L-threonate helps in bone remodeling?In an in vitro study, calcium L-threonate was one of the metabolites that was suggested to influence the formation of mineralized nodules and collagenous proteins (Rowe et al. 1999).

In rabbit model study, L-threonate, specifically calcium L-threonate was found to inhibit the bone resorption of osteoclasts measured by the levels of type I collagen C-telopeptide (CTx) (He et al. 2005).

Calcium L-threonate was shown to have stimulation effects on proliferation rate, ALP activity and mineralization nodules formation of osteoblasts cultured in vitro and the effect was stronger than calcium gluconate or calcium chloride. Therefore, calcium L-threonate is a powerful compound in enhancing bone formation, while at the same time inhibiting the bone resorption of osteoclasts.

What is hydrolysed collagen?Hydrolysed collagen is derived from bone and cartilage. It composed of amino acids which are essential in building collagen and tissues in human body.

Studies have shown that orally administered collagen hydrolysate were absorbed in intestine, accumulated in cartilage and increased the synthesis of extracellular matrix macromolecules by chondrocytes, therefore it is helpful for patients with joint disorder, specifically osteoarthritis (Bello et al. 2006). Further, a 24-week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain showed that the use of collagen hydrolysate significantly reduced pain, support joint health and possibly reduce the risk of joint deterioration (Clark et al. 2008).

Dalam kajian model arnab, L-threonate, terutamanya kalsium L-threonate telah didapati menghalang resorpsi tulang oleh osteoklas melalui pengukuran tahap kolagen C-telopeptida (CTx) Jenis I (He et al. 2005).

Kalsium L-threonate telah menunjukkan kesan-kesan perangsangan ke atas kadar proliferasi, aktiviti ALP dan pembentukan nodul bermineral oleh osteoklas yang dikultur secara in vitro, dan kesannya adalah lebih kuat berbanding kalsium glukonat dan kalsium klorida. Maka, kalsium L-threonat adalah sejenis sebatian yang kuat dalam meningkatkan pembentukan tulang, dan pada masa yang sama, menghalang resorpsi tulang oleh osteoklas.

Apakah itu kolagen hidrolisat?Kolagen hidrolisat diperolehi daripada tulang dan rawan. Ia terdiri daripada amino asid-amino asid yang diperlukan dalam pembentukan kolagen dan tisu-tisu dalam tubuh badan manusia.

Kajian-kajian telah menunjukkan bahawa kolagen hidrolisat yang diambil secara lisan telah diserap dalam usus, berkumpul di dalam rawan dan meningkatkan sintesis makromolekul matriks ekstraselular oleh kondrosit. Maka, kolagen hidrolisat sangat berguna untuk pesakit-pesakit yang mengalami gangguan sendi, terutamanya osteoarthritis (Bello et al. 2006). Tambahan pula, satu kajian selama 24 minggu yang menggunakan kolagen hidrolisat sebagai supplemen ke atas atlit-atlit yang mengalami kesakitan sendi yang disebabkan aktiviti-aktiviti sukan, telah menunjukkan bahawa penggunaan kolagen hidrolisat mengurangkan kesakitan secara signifikan, menyokong kesihatan sendi dan menunjukkan kemungkinan dalam mengurangkan risiko kemerosotan sendi (Clark et al. 2008).

Apakah itu γ-oryzanol?Ia merupakan minyak dedak padi yang diekstrak daripada lapisan luar bijian padi. γ-oryzanol tinggi dalam asid lemak mono tak tepu (MUFA) dan asid lemak poli tak tepu (PUFA), khasnya omega-6 (38%). Satu kajian intervensi selama 10 minggu yang dijalankan di negara Thai telah menunjukkan bahawa γ-oryzanol berkesan dalam menggurangkan tahap jumlah kolesterol dan LDL-kolesterol (Utarwuthipong et al. 2009). Tambahan pula, kajian US Nurses’ Health (n=80,082 wanita) telah melaporkan bahawa penggantian lemak tepu dengan PUFA dalam pemakanan harian dapat mengurangkan risiko relative untuk penyakit kardiovaskular sebanyak 42%. (Hu et al. 1997).

Apakah itu Kalsium L-threonate?Kalsium L-threonate merupakan sejenis sebatian yang khas digunakan dalam rawatan penyakit tulang. Acid L-threonic adalah sejenis metabolit vitamin C yang aktif di mana ia berkebolehan dalam meningkatkan bioavailability bahan mineral, seperti kalsium. Vitamin C terkenal sebagai penanda bagi pembentukan osteoblas dan juga menunjukkan kebolehannya dalam merangsang prokolagen serta meningkatkan sintesis kolagen (Morton et al. 2001; Hall et al. 1998; Franceschi & Lyer 1992).

Bagaimanakah L-threonate dapat membantu dalam pembentukan semula tulang?Dalam kajian in vitro, kalsium L-threonate merupakan salah satu jenis metabolit yang telah dicadangkan dapat mempengaruhi pembentukan nodul bermineral dan protein berkolagen (Rowe et al. 1999).

CaL-Threonate+ merupakan gabungan kalsium L-threonate, kolagen hidrolisat & γ-oryzanol untuk:

What is γ-oryzanol?It is rice bran oil extracted from the outer brown layer of rice. Rice bran oil is high in monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), specifically omega-6 (38%). A 10-week intervention study conducted in Thailand showed that rice bran oil is effective in lowering total cholesterol and LDL-C (Utarwuthipong et al. 2009). In addition, the US Nurses’ Health Study (n=80,082 women) have reported a 42% reduction in relative risk for cardiovascular disease when PUFA was substituted for saturated fat in diets (Hu et al. 1997).

CaHO OH

OH o

o o

o

OH

OH

L-threonate

OH

improve bone healthinhibiting bone resorption

and encouragingbone formation

reduce joint pain rebuild the joints, cartilage and collagen

Meningkatkan kesihatantulang melalui menghalangresorpsi tulang & membina

semula sendi-sendi,rawan dan kolagen

mengurangkankesakitan sendi

membina semulasendi-sendi,

rawan dan kolagen