DAFTAR ISI

Halaman

HALAMAN JUDUL..................................................................................... i

HALAMAN PENGESAHAN TIM PENGUJI.............................................. ii

HALAMAN PERNYATAAN KEASLIAN TULISAN................................ iii

HALAMAN PERSEMBAHAN.................................................................... iv

KATA PENGANTAR................................................................................... v

DAFTAR ISI.................................................................................................. vii

DAFTAR TABEL.......................................................................................... x

DAFTAR GAMBAR..................................................................................... xi

DAFTAR LAMPIRAN.................................................................................. xii

ABSTRAK..................................................................................................... xiii

ABSTRACT..................................................................................................... xiv

BAB I PENDAHULUAN.......................................................................... 1

I.1. Latar Belakang ......................................................................... 1

I.2. Rumusan Masalah..................................................................... 2

I.3. Tujuan....................................................................................... 3

I.4. Manfaat..................................................................................... 3

BAB II TINJAUAN PUSTAKA................................................................. 5

II.1 Tinjauan Pustaka...................................................................... 5

II.1.1 Permasalahan Terkait Obat (PTO)................................. 5

II.1.1.1 Pengertian......................................................... 5

II.1.1.2 Langkah Mengidentifikasi PTO....................... 5

II.1.1.3 Klasifikasi PTO Berdasarkan PCNE V.6.02.... 6

II.1.2 Geriatri........................................................................... 9

II.1.3 Osteoartritis (OA).......................................................... 10

II.1.3.1 Epidemiologi.................................................... 10

II.1.3.2 Patofisiologi..................................................... 10

II.1.3.3 Klasifikasi OA.................................................. 11

II.1.3.4 Manifestasi Klinis............................................ 12

II.1.3.5 Tanda dan gejala klinis..................................... 13

II.1.4 Penatalaksanaan Osteoartritis........................................ 15

II.1.4.1 Terapi Non-farmakologis................................. 15

II.1.4.2 Terapi Farmakologi.......................................... 16

II.1.4.3. Pembedahan.................................................... 25

II.2 Landasan Teori......................................................................... 28

II.3 Kerangka Konsep..................................................................... 29

II.4 Hipotesis................................................................................... 29

BAB III METODE PENELITIAN................................................................ 30

III.1 Alat dan Bahan........................................................................ 30

III.1.1 Alat.............................................................................. 30

III.1.2 Bahan.......................................................................... 30

III.2 Tempat dan waktu penelitian.................................................. 30

III.3 Populasi dan Sampel............................................................... 30

III.4 Besar Sampel.......................................................................... 31

III.5 Variabel penelitian.................................................................. 32

III.6 Definisi operasional................................................................ 33

III.7 Jalannya Penelitian.................................................................. 34

III.7.1 Jenis metode penelitian................................................ 34

III.7.2 Metode pengumpulan data........................................... 34

III.8 Analisis Hasil Penelitian......................................................... 34

III.8.1 Jenis dan pengolahan data............................................ 34

III.8.2 Analisis data................................................................. 34

III.9 Skema Penelitian..................................................................... 35

BAB IV HASIL DAN PEMBAHASAN....................................................... 36

IV.1 Karakteristik pasien geriatri penderita Osteoartritis............... 36

1. Karakteristik pasien berdasarkan umur............................... 37

2. Karakteristik pasien berdasarkan jenis kelamin.................. 37

3. Karakteristik pasien berdasarkan faktor komorbiditas........ 38

4. Karakteristik pasien berdasarkan jenis terapi

farmakologis....................................................................... 40

5. Jenis obat Osteoartritis........................................................ 41

IV.2 PTO yang terjadi pada pasien geriatri penderita OA berdasarkan PCNE

V.6.2....................................................................................... 42

BAB V PENUTUP........................................................................................ 48

V.1 Kesimpulan.............................................................................. 48

V.2 Saran......................................................................................... 48

DAFTAR PUSTAKA................................................................................... 49

LAMPIRAN................................................................................................... 56