bioinformatika history

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 Arif Rahman Sadjuri, S.Si.

R & D Indonesia Biotechnology Students forum

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1. Apa itu Bioinformatika ?

2. Bioinformatika VS Biologi Komputasi ?

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BioinformatikaGenome & Proteome exploration

³ome revolution´

Data Exploding ingenome and proteome field

revolution on

information-

communication

technology

BIOINFORMATICS

Storage

( Find & Interpretation)

Analysis

(Comparison )Analysis

(Prediction and Simulation)

1. Database of DNA

2. Database of Protein

3. Database of RNA

transcription

1. looking for similarity

- Alignment (2D data i.e.

sequence)

PairwiseAlignment

Multiple Alignment

- Superimpose (3D data

i.e. protein structure)

2. Searching for pattern

1. Prediction of gene

structure, or protein

Function, phylogenetic

2. Simulation of gene

interaction and

simulation of dynamic of 

 protein structure

(molecular dynamic)

Computational Biology

X-ray diffraction data

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BIOINFORMATIK³The field of science in which biology, computer science,

and information technology merge to form a single

discipline´

Ultimate goal: to enable the discovery of new biological

insights as well as to create a global perspective from whichunifying principles in biology can be discerned.

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Dayhoff y Dr. Margaret Oakley Dayhoff (1925-1983) pionir

dalam penggunaan komputasi di bidang kimia danbiologi

y Dianggap sebagai salah satu penemu Bioinformatics

y 1961 Membuat alat untuk membantu menentukansekuen asam amino dengan overlapping sekuen

asam amino (Point Accepted Mutation).y Inisiator "Atlas of Protein Sequence and Structure"

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Needleman-Wunsch

y NeedlemanWunsch algorithm melakukan Global Alignmentterhadap 2 sekuen

y  Algoritma ini diusulkan oleh Saul Needleman and Christian Wunsch yang dipublikasikan pada artikel  A general method applicable to thesearch for similarities in the amino acid sequence of two proteins, J MolBiol. 48(3):443-53.

y Untuk sekuen protein dan nukleotida

y Dynamic programming, aplikasi pertama dynamic programmingkepada perbandingan (comparing) sekuen biologi

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Staden

y Sequence Data Handling by Computer

y Komputer tidak perlu tinggi

y Penyimpanan (storage), editing and analysis sekuenDNA dan asam amino

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GenBank

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NCBINational Center Biotechnology Information

y Computerized information processing methods for the conduct of biomedical research

y  www.ncbi.nlm.nih.gov 

y Division of the National Library of Medicine (NLM) at theNational Institutes of Health (NIH).

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EMBnet Network

Since its creation in 1988, EMBnet has evolved from an informal networkof individuals in charge of maintaining biological databases into the only organization world-wide bringing bioinformatics professionals to worktogether to serve the expanding fields of genetics and molecular biology.

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BLAST

Basic Local Alignment Search Tool

y Similarity Searching

y

NCBI

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EMBL-EBI

European Molecular Biology Laboratory EBI(European Bioinformatic Institute)

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First Bacterial Genome

y H aemophilus Influenzae

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uman Genome

y 3 milyar pasangbasa

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APLICATION

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MOLECULAR RESEARCHy LIPI Bioteknologi

y Biotrop

y Eijkman

y Namru

y Biofarma

y Pathology RSHS

y

Universitas & Institut

BPPT

BB Biogen

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MED

ICALy SARS

y Bird Flu

y Biofarma

y Sanbe farma

y Eijkman

y Namru

y

Hospital lab (RSHS)

SCI (Stem Cell &Cancer Institute)

Kalbe Farma Mochtar Riyadi

Research Center

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IND

USTRI

y (Charon Pokhpan- CPB) Udang

y (Astra Agro Lestari) Kelapa sawit

y (Bisi International) Jagungy (EWINDO) Bibit Sayur Mayur

y (LONSUM) Kelapa Sawit

POLICE DEPARTEMENy Fingerprint molecular identification

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Thank You

Hope You Motivated To Learn More About

Bioinformatic