Reactions 1420 - 22 Sep 2012

SPregabalin

Heart failure: case reportA 64-year-old man developed heart failure during

treatment with pregabalin for paraesthesia. He initiallyreceived oral pregabalin 150mg, which was increased aweek later to 300 mg/day. Over the next 3 months, hedeveloped peripheral oedema and gained weight. Despitepregabalin withdrawal, he was subsequently hospitalisedunconscious, with wheezing, lip cyanosis and orthopnoea.Chest X-ray revealed cardiomegaly with a butterfly shadow,suggesting congestive heart failure and pulmonaryoedema. By the next day, he had responded well to oxygenand furosemide. His heart failure and oedema improvedand his weight gain resolved over 7 days.

Author comment: "We report here a patient with noprevious history of chronic heart failure who developed heartfailure while on long-term oral pregabalin."Matsuki Y, et al. Heart failure associated with pregabalin use. Pain Physician 15:E537-E538, No. 4, Jul-Aug 2012 - Japan 803077402

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Reactions 22 Sep 2012 No. 14200114-9954/10/1420-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved