Reactions 972 - 11 Oct 2003

Etofenamate

Allergic contact dermatitis: case reportA 44-year-old man developed allergic contact dermatitis

unrelated to sun exposure during treatment with topicaletofenamate gel [‘Teril’] for soreness of the right inner thigh.He also had a 10-year history of contact dermatitis associatedwith metal ingredients.

On day 3 of treatment with etofenamate gel [dosage notstated], the man experienced pruritus at the application site.The following day, erythema, vesicles and exudationdeveloped at the application site. Etofenamate gel wasdiscontinued. He was treated with topical corticosteroids andthe eruption resolved.

Subsequent patch tests with a standard series andingredients of the gel were positive for etofenamate and nickelsulphate, but were negative for the other six NSAIDs tested,which included three other anthranilic acid derivatives(mefenamic acid, meclofenamic acid and niflumic acid).

Author comment: "Only a few cases of allergic contactdermatitis due to etofenamate have been reported in theEnglish literature."Chu C-Y, et al. Allergic contact dermatitis from etofenamate without cross-sensitization to other anthranillic acid derivatives. Dermatology 206: 341-342, No.4, 2003 - Taiwan 807214420

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Reactions 11 Oct 2003 No. 9720114-9954/10/0972-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved