Reactions 1341 - 5 Mar 2011

Cetuximab

Periungual inflammation treated with adapalene:case report

A 49-year-old man with metastatic renal cancerdeveloped periungual inflammation after treatment withcetuximab.

Following numerous cycles of fluorouracil-basedchemotherapy, the man received cetuximab [dosage androute not stated]. Afterwards, he developed an acneiformskin rash on his face and periungual inflammation.

The rash was almost completely alleviated withminocycline, but the periungual inflammation increasedand became more painful. Application of betamethasonebutyrate propionate and zinc oxide had no effect on theinflammation. Adapalene was applied to the left foot andbetamethasone butyrate propionate was applied to theright. After 2 weeks, inflammation on the left foot haddecreased significantly more than the right. Therefore,adapalene was applied to both feet. The periungualinflammation was markedly reduced and pain diminishedby almost 30%.Hachisuka J, et al. Effect of adapalene on cetuximab-induced painful periungualinflammation. Journal of the American Academy of Dermatology 64: e20-e21, No.2, Feb 2011. Available from: URL: http://dx.doi.org/10.1016/j.jaad.2009.12.019 -Japan 803050175

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Reactions 5 Mar 2011 No. 13410114-9954/10/1341-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved