uji analgesik infusa temu kunci pada mencit betina galur swiss

7/23/2019 Uji Analgesik Infusa Temu Kunci Pada Mencit Betina Galur Swiss

1/40

GIGH KEKANGSLH LEIWSK ]GJW HWECL (Hkgjtigrlk tkemwrk}k Rfpb%,

]GR@KMKT OWJAK@ NGALK] JGECL] BG]LEK NKAWR S^LSS \KEN

MLLEMWHSL KSKJ KSG]K]

Mlswswe fag`?

TRKH]LHKE HGAFJTFH K

IS] K

AKBFRK]FRLWJ IKRJKHFAFNL MKSKR

IKHWA]KS IKRJKSL

WELYGRSL]KS SKEK]K M@KRJK

\FN\KHKR]K

24;;


2/40

ll

MKI]KR LSL

@KAKJKE OWMWA %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 4lMKI]KR LSL%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 4ll

BKB L

K% AK]KR BGAKHKEN %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 4;

B% TGRJKSKAK@KE%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 42

C% JKEIKK]%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 42

M% ]WOWKE%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 42

BKB LL

K% SLS]GJK]LHK ]KEKJKE%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 43

B% FBK] ]RKMLSLFEKA%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 47

C% E\GRL %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 49

M% KEKANG]LHK%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 40

G% TKRKSG]KJFA %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% ;4

I% KSKJ KSG]K]%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% ;4

N% TGE\KRLKE%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% ;4

@% WOL KEKANG]LHK%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% ;2

L% AKEMKSKE ]GFRL%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% ;=

O% @LTF]GSLS%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% ;=

BKB LLL

K% OGELS MKE RKECKENKE TGEGAL]LKE%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% ;7

B% JG]FMG TGEGAL]LKE%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% ;7

C% YKRLKBGA MKE MGILELSL FTGRKSLFEKA TGEGAL]LKE %%%%%%%%%%%%%%%%%%%%%%%%%%%%%% ;7

M% BK@KE K]KW JK]GRL TGEGAL]LKE%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% ;9

G% KAK] K]KW LES]RWJGE TGEGAL]LKE %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% ;>

I% ]K]K CKRK TGEGAL]LKE%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% ;>

N% KEKALSLS @KSLA%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% ;*;9 cj! almk`*

almk` bgrbge}wh sgnl}lnk jgagbkr! jge|grwtkl sgaktw}! tkeoken ;*;!7 cj! tgagtk`

mkwe sgrlen skjk tkeoken mgenke }kenhkl mkwe8 `gakl mkwee|k }gnkh! bge}wh akesg}

agbkr k}kw knkh ofrfen! wowen mkwe rweclen! tgrjwhkke `kaws }g}ktl bknlke bk~k`

knkh bgrkjbw} }grw}kjk sgtkeoken tgr}wakenke! ~krek `gakl mkwe `lokw jwmk!

agbkre|k 7*;; cj (Take}ws! 2440,%

Bwenk }kekjke lel bgrwtk swsweke bwalr }lmkh bgrbk}ks! ml hg}lkh mkwe!

mlalemwenl fag` 2 stk}`k! tkeoken }kenhkl =; cj! wjwje|k }kenhkl }grsgjbwe|l

mkakj 2 `gakl mkwe }grwowen% Hgaftkh bwenke|k 3 bwk` agtks! rweclen% Jk`hf}k

bwenke|k 3 bwk`! ~kreke|k jgrk` jwmk k}kw hwelen*tw}l`! bgrbge}wh }kbwen 74*72

jj! bknlke k}ks }kowh bgrbgak`*bgak`! bgrbge}wh akesg} mgenke agbkr = jj mke

tkeoken ;0 jj% Bgeken skrle|k ; igr}la bgskr! hgtkak skrle|k bge}wh nkrls jgjbwhk

sgckrk jgjkeoken% Aklee|k bgrwtk blblr*blblrke (s}kjlefmlk, bwak} }gawr }grbkalh}wjtwa! jgrk` jwmk k}kw hwelen agjfe! nwemwa! 9 tgr}wakenke! mke whwrkee|k 27>

cj% Tw}lh bwenke|k bgrwtk bkhka bwk` 3 rwken! bke|kh blol mkakj sg}lkt rwken

(Take}ws! 2440,%


7/40

7

=% HKEMWENKE HLJLK

Rljtken }gjw hwecl jgenkemwen jle|kh k}slrl! sktfele! iakyfeflm!

hwrhwjle! }keele! m*bwregfa! m*tlege sgs{wl}grtge (Take}ws! 2440,%

7% JKEIKK]

Rljtken }gjw hwecl jgjlalhl jkeikk} sgbknkl tgawrw` mk`kh k}kw we}wh

jgekennwakenl bk}wh! tgawrw` hge}w}! tgekjbk` ekisw jkhke! jge|gjbw`hke

skrlk~ke! bwjbw jkskh! mke tgjkcw hgawkre|k Klr Swsw Lbw (KSL,! Tgrkske mkeleiwsk rljtken }gjw hwecl jgjlalhl mk|k kekang}lh mke ke}ltlrg}lh (Take}ws! 2440,%%

B% FBK] ]RKMLSLFEKA

Fbk} }rkmlslfeka kmkak` fbk} |ken bgrkska mkrl bk`ke }wjbw`*}wjbw`ke! `g~ke!

jlegrka mke k}kw tgrsgmlkke nkagelhe|k k}kw ckjtwrke mkrl bk`ke*bk`ke }grsgbw}

|ken bgawj jgjtwe|kl mk}k halels mke mltgrnwekhke mkakj wsk`k tgenfbk}ke

bgrmkskrhke tgenkakjke (Kefelj! ; Jgl 244=, ( Nwek~ke mke

Jwa|kel! 244=,%

Ml skjtlen hgwennwakee|k! fbk} bk`ke kakj ownk jgjlalhl bgbgrktk

hgagjk`ke |ken ownk jgrwtkhke hgemkak mkakj tgengjbkenke fbk} }rkmlslfeka


8/40

9

ke}krk akle? gigh ikrjkhfafnlse|k agjk`! bk`ke bkhw bgawj }grs}kemkr mke bgrslik}

`lnrfshftls sgr}k yfawjlegs! bgawj mlakhwhke wol halelh mke jwmk` }grcgjkr bgrbknkl

jlhrffrnkelsjg% Wtk|k*wtk|k tgengjbkenke fbk} }rkmlslfeka mktk} ml}gjtw`

mgenke bgrbknkl ckrk mgenke tgemghk}ke*tgemghk}ke }gr}ge}w! sg`lennk ml}gjwhke

bge}wh fbk} }rkmlslfeka |ken }gak` }grwol h`kslk} mke hgkjkekee|k! blsk

mltgr}kennwenok~kbhke sgckrk lajlk` sgr}k jgjgew`l lemlhksl jgmls! |kl}w

hgafjtfh fbk} il}f}grktl k}kw il}fikrjkhk% We}wh jgemktk}hke trfmwh il}fikrjkhk

`krws jgakawl bgbgrktk }k`kt (wol ikrjkhfafnl! }fhslsl}ks mke wol halelh, `lennk blskjgeok~kb mke jgenk}ksl hgagjk`ke }grsgbw} ( Nwek~ke mke Jwa|kel! 244=,%

@lennk skk} lel! fbk}*fbk} }rkmlslfeka mlkennkt mke ml`krkthke bgrtgrke mkakj

wsk`k*wsk`k tgecgnk`ke mke tgenfbk}ke tge|khl}! sgr}k tgelenhk}ke }krki hgsg`k}ke

jks|krkhk}% Tgennwekke `lennk skk} lel mlmkskrhke tkmk mwnkke*mwnkke `ksla

tgenkakjke k}kw tgeng}k`wke |ken ml}grwshke sgckrk }wrwe*}gjwrwe! mke bgawj

mlmkskrhke tkmk `ksla tgegal}lke mke `ksla tgrcfbkke |ken sghskjk% Sgswkl mgenke

rgeckek tgjgrle}k` we}wh jgjtgrawks mke jgelenhk}hke jw}w tgak|keke hgsg`k}ke

hgtkmk jks|krkhk}! jkhk tgekenkeke tgrsfkake fbk} }rkmlslfeka sgr}k

tgengjbkenkee|k sg`krwse|k mktk} jgefafen tgjgrle}k`% Tgengjbkenke fbk}

}rkmlslfeka `krws mlmkskrhke tkmk hgtge}lenke jks|krkhk}! lel bgrkr}l bk`~k

tgennwekke fbk} }rkmlslfeka we}wh tgenfbk}ke `krws twe|k mkskr*mkskr |ken hwk}!

sg`lennk tgennwekke mke keowrke we}wh jgennwekhkee|k `krws bgekr*bgekr mktk}

mltgr}kennwenok~kbhke (@wsle! ;


9/40

>

hgoken f}f}% Rksk e|grl mlsgbkbhke fag` rkenskenke jghkelsjg k}kw hljlk~l! hkafr

k}kw als}rlh |ken mktk} jgeljbwahke hgrwskhke okrlenke mke jgagtkshke zk} |ken

mlsgbw} jgmlk}fr e|grl (]ok| mke Rk`krmok! 2442,%

Rksk e|grl ml}grljk fag` rgsgt}fr h`wsws! |ken jgrwtkhke wowen s|krki bgbks%

Sgckrk iwenslfeka ml bgmkhke jgeokml 2 ogels rgsgt}fr?

;% Jghkefrgsgt}fr

Swk}w rgsgt}fr |ken jgegrwshke rkenskenke e|grl tgrjwhkke jgakawl sgrkbw}

K* mga}k bgrjlgale%2% ]grjfrgsgt}fr

Swk}w rgsgt}fr |ken jgegrwshke rkenskenke e|grl hgmwk jgakawl sgrkbw}*

sgrkbw} C*|ken }lmkh bgrjlgela%

(Jw}sc`agr!;


10/40

0

Ckrk tgjbgrke}kske e|grl?

;, Jgen`kakenl tgjbge}whke rkensken mkakj rgsgt}fr e|grl tgrligr fag`

kekang}lhk tgrligr k}kw fag` keks}g}lh afhka%

2, Jgen`kakenl tge|kawrke rkensken e|grl mkakj s|krki sgesfrls! jlskae|k

mgenke keks}g}lh afhka%

3, Jgen`kakenl twsk} e|grl mkakj sls}gj s|krki twsk} mgenke kekang}lhk sge}rka

(ekrhf}lh, k}kw mgenke keks}g}lh wjwj (]ok| mke Rk`krmok! 2442,%

M% KEKANG]LHK

Kekang}lhk kmkak` sge|k~k |ken mkakj mfsls }grktg}lh jgrlenkehke k}kw

jgeghke rksk e|grl! }ketk jgjlalhl hgrok kegs}gsl wjwj% Bgrmkskrhke tf}gesl hgrok!

jghkelsjg hgrok mke gigh skjtlen kekang}lhk mlbgmkhke mkakj 2 hgafjtfh |kl}w

kekang}lhk |ken bgrh`kslk} hwk}! bghgrok tkmk twsk} (`ltfkekang}lh! hgafjtfh Ftlk},

mke kekang}lhk |ken bgrslik} agjk` (skjtkl sgmken, bghgrok }grw}kjk tkmk tgrligr

(Jw}sc`agr! ;


11/40

jn& nBB8 ;!= jn& nBB8 2!0 jn&

nBB jkslen*jkslen jgeweowhhke tgrsge mk|k trf}ghsl sgbgskr 32!9'8 72'8 mke

99'%

]kbga L% Mk}k rk}k*rk}k owjak` ngalk} jgecl}! rk}k*rk}k tgrsge mk|k trf}ghsl

hgafjtfh tgrakhwke leiwsk }gjw hwecl tkmk }lnk tgrlenhk} mfsls

mlsgr}kl hfe}rfa%

Tgrakhwke Rk}k*rk}k owjak` ngalk} jgecl}Rk}k*rk}k tgrsge mk|k

trf}ghsl

Hfe}rfa egnk}li >4 4'

Hfe}rfa tfsl}li ;>!7 >7'

Leiwsk }gjw hwecl

(4!> jn&nBB,=>!2 32!9'

Leiwsk }gjw hwecl

(;!= jn&nBB,

33!9 72'

Leiwsk }gjw hwecl

(2!0 jn&nBB,23!0 99'


27/40

27

Sgakeow}e|k mlakhwhke wol Sc`giig we}wh jgeng}k`wl kmk tgrbgmkke bgrjkhek

k}kw tgrbgmkke }lmkh bgrjkhek ke}kr hgafjtfh tgrakhwke% @ksla kekalsls mkrl wol

Sc`giig mktk} mlal`k} tkmk }kbga ml bk~k` lel%

]kbga LL% Mk}k rk}k*rk}k owjak` ngalk} jgecl}! rk}k*rk}k ' mk|k trf}ghsl hgafjtfh

tgrakhwke leiwsk }gjw hwecl tkmk }lnk tgrlenhk} mfsls mlsgr}kl hfe}rfa mke

wol Sc`giig

Hgafjtfh

Rk}k*rk}k owjak`

ngalk} jgecl} 'MTSG

@ksla wol Sc`giig

}gr`kmkt hgafjtfh

; 2 3 = 7

; >4 4;7!;= * BB ]B BB BB

2 ;>!7 >79!42 BB * ]B ]B ]B

3 =>!2 32!9

= 33!9 72;4!=; BB ]B ]B * ]B

7 23!0 997!29 BB ]B ]B ]B *

Hg}grkenke?; : hgafjtfh hfe}rfa (*, k{wkmgs

2 : hgafjtfh hfe}rfa (, tkrksg}kjfa

3 : hgafjtfh tgrakhwke leiwsk }gjw hwecl mfsls 4!> jn&nBB

= : hgafjtfh tgrakhwke leiwsk }gjw hwecl mfsls ;!= jn&nBB

7 : hgafjtfh tgrakhwke leiwsk }gjw hwecl mfsls 2!0 jn&nBB

BB : bgrbgmk bgrjkhek (t14!47,

]B : bgrbgmk }lmkh bgrjkhek (t54!47,

SG : s}kemkr grfr

MT : mk|k trf}ghsl

Hgafjtfh hfe}rfa tfsl}li tkrksg}kjfa jgjbgrlhke `ksla bgrbgmk bgrbgmk

bgrjkhek we}wh hfe}rfa egnk}li k{wkmgs! sgmkenhke we}wh hgafjtfh tgrakhwke

leiwsk }gjw hwecl mfsls 4!> jn&nBB8 ;!= jn&nBB8 2!0 jn&nBBB jgjbgrlhke `ksla

|ken bgrbgmk }lmkh bgrjkhek%

Bgrmkskrhke `ksla wol Sc`giig lel! mktk} mlhk}khke bk`~k leiwsk }gjw hwecl

mfsls 4!> jn&nBB8 ;!= jn&nBB8 sgr}k 2!0 jn&nBB jgjtwe|kl tgrsge mk|k trf}ghsl

|ken sg}krk mgenke tkrksg}kjfa ;!3 jn&24n% Ekjwe! olhk mlal`k} mkrl tgrsge mk|k


28/40

29

trf}ghsle|k (tkmk nkjbkr L,! mktk} mlhk}khke bk`~k mgenke mfsls 2!0 jn&nBB khke

jgjbgrlhke tgrsge (', mk|k trf}ghsl |ken agbl` bgskr olhk mlbkemlenhke mgenke

mfsls ;!= jn& nBB k}kwtwe 4!> jn& nBB% Sg`lennk khke agbl` gigh}li olhk

jgennwekhke mfsls leiwsk }gjw hwecl 2!0 jn& nBB sgbknkl kekangslh tkmk jgecl}%

Nkjbkr L% Mlknrkj bk}ken tgrsge (', trf}ghsl tkmk hgafjtfh tgrakhwke wol

Mkrl nkjbkr ml k}ks mke tkmk }kbga LL! }gral`k} bk`~k elakl s}kemkr grfr mkrl }lkt

tgrakhwke skenk}ak` bgskr% @ka lel jwenhle }grokml hkrgek kmke|k hgskak`ke mkakj

tge|we}lhhke sgr}k tgenkjk}ke fag` trkh}lhke |ken bgrbgmk ke}krk |ken sk}w mgenke

|ken aklee|k

Hgskak`ke*hgskak`ke |ken jwenhle }grokml mkakj trkh}lhwj lel mktk}

mlsgbkbkhke fag` ?

;% Ikh}fr tge|we}lhke |ken }lmkh khwrk} (}lmkh }gtk} tkmk }l}lh tge|we}lhke,! |ken

jge|gbkbhke trfsgs kbsfrtsl mke mls}rlbwsl jgeokml }lmkh }gtk} mke }lmkh ~kokr

tkmk }lkt `g~ke wol%

2% Ikh}fr hgkmkke `g~ke wol (jgecl}, |ken jgjken jgjlalhl hfemlsl }wbw` |ken

stgslilh mkakj jgekennktl rkensken mkrl e|grl mke kekangslhe|k%


29/40

2>

3% Tgenkjk}ke |ken mlakhwhke fag` }lkt frken bgrbgmk! khlbk}e|k }grmktk}

tgrbgmkke tgrsgtsl owjak` ngalk} |ken jgenkhlbk}hke jwecwae|k mk}k |ken

blks%

=% Ikh}fr hfe}kjleke |ken }ljbwa mkakj }kekjke fbk}! swe}lhke mke tgrkak}ke

|ken akle sg`lennk }grokml tgrngsgrke iwensl hgrok mkrl |ken sgbgekre|k%

Mkrl tgrcfbkke |ken mlakhwhke mgenke jg}fmg rkensken hljlk! }grmktk}

hgagbl`ke mke hghwrkenke tkmk jg}fmg }grsgbw}! ke}krk akle ?Hgagbl`ke Hghwrkenke

;% Jwrk` mke sgmgr`kek%

2% Jg}fmg lel cwhwt tghk we}wh

tgenwolke sge|k~k |ken

jgenkemwen mk|k kekangslh

agjk`%

;% Jg}fmg rkensken hljlk hwrken stgslilh

blak mlnwekhke mkakj tgrcfbkke gigh

fbk} kekangslh hkrgek kmk sge|k~k akle

|ken ownk mktk} jgenwrkenl rksk e|grl

}ktl }lmkh jgjlahl mk|k kekangslh%

2% ]lmkh stgslilh we}wh s}grflm hkrgek mktk}

ownk mlnwekhke wol aklee|k sgtgr}l wol

ke}lleiakjksl sg`lennk `ksla |ken

mltgrfag` bgawj mktk} mltks}lhke

jgrwtkhke `ksla mk|k kekangslh mke tgraw

mlakeow}hke mgenke wol kekangslh aklee|k%

3% Tgenkjk}ke ngalk} jgecl} bgrslik}

swboghli


30/40

20

BKB LY

HGSLJTWAKE MKE SKRKE

K% HGSLJTWAKE

Mkrl `ksla kekalsls mk}k mke tgjbk`kske! mktk} mlkjbla hgsljtwake?

;% mkrl tgrcfbkke ml k}ks!}grbwh}l bk`~k leiwsk rljtken }gjw hwecl jgjlalhl gigh

kekangslh

2% bgskr hgclae|k gigh kekangslh mle|k}khke mgenke tgrsge (', mk|k trf}ghslmljkek leiwsk }gjw hwecl (Hkgjtigrlk tkemwrk}k Rfpb%, tkmk mfsls 4!>

jn&nBB8 ;!= jn&nBB8 mke 2!0 jn&nBB jgjtwe|kl tgrsge (', trf}ghsl

bgr}wrw}*}wrw} 32!9'8 72'8 mke 99'

B% SKRKE

Bgrmkskrhke `ksla tgegal}lke! bgbgrktk skrke ownk mktk} mlhgjwhkhke?

;% Tgraw mlakhwhke lsfaksl sge|k~k blfkh}li tkmk leiwsk }gjw hwecl sg`lennk

jgjtgrhwk} mwnkke }ge}ken sge|k~k |ken bgr}kennwenok~kb tkmk gigh

kekangslh leiwsk }gjw hwecl%

2% Tgraw mlakhwhke wol kekangslh tkmk jgecl} oke}ke nkawr S~lss we}wh jgeng}k`wl

ktkhk` leiwsk }gjw hwecl jgjbgrlhke `ksla |ken skjk k}kw }lmkh }grhkl}

mgenke gigh kekangslhe|k%


31/40

2 jn&n BB

Mfsls we}wh jgecl} 24 n : 4!> jn p 24 n

: ;= jn&24 n BB jgecl}

b% Mfsls we}wh g~ke wol ;!= jn&n BB

Mfsls we}wh jgecl} 24 n : ;!= jn p 24 n

: 20 jn&24 n BB jgecl}

c% Mfsls we}wh g~ke wol 2!0 jn&n BB

Mfsls we}wh jgecl} 24 n : 2!0 jn p 24 n

: 79 jn&24 n BB jgecl}

Mfsls Kskj Ksg}k} ? 74jn&hn BB `g~ke wol

Tgr`l}wene yfawjg tgjbgrlke

Hfe}rfa (*,

Akenswen ml bgrl k{wkmgs} 4!7jA

Yfawjg tgjbgrlke kskj ksg}k} hfe}rfa (*,

hfe}rfa (*, kskj ksg}k}

M : 74jn&hn BB! C : ;4 jn&jA

BB :20!= n BB :2

74jn&hn BB p 20!= n : ;4jn&jA p

Y

74jn&hn BB p 2

p Y

Y : 4!;= jA Y : 4!;7 jA

BB : 34!39 n BB : 27!=

74jn&hn BB p 34!39 n : ;4jn&jA

p Y

74jn&hn BB p 27!= n : ;4jn&jA p

Y

Y : 4!;7 jA Y : 4!;3 jA


34/40

Yfawjg tgjbgrlke kskj ksg}k}

Hfe}rfa tfsl}li (tkrkcg}kjfa, Hfe}rfa tfsl}li (tkrksg}kjfa,

M : 4!4497jn&n! C : 4!7jn&jA M : 74jn&hn BB! C : ;4 jn&jA

BB : 29!7 n BB : 29!7 n

4!4497jn&n p 29!7 n : 4!7jn&jA p

Y


p Y

Y : 4!3= jA Y : 4!;3 jA

BB : 33!22n BB : 33!22n

4!4497jn&n p 33!22 n : 4!7jn&jA

p Y


p Y

Y : 4!=3 jA Y : 4!;> jA

BB : 3;!9>n BB : 3;!9>n

4!4497jn&n p 3;!9> n : 4!7jn&jA

p Y

74jn&hn BB p 3;!9> n : ;4jn&jA

p Y

Y : 4!=;jA Y : 4!;9 jA

BB : 27!9 n BB : 27!9 n

4!4497jn&n p 27!9 n : 4!7jn&jA p

Y

74jn&hn BB a p 27!9 n : ;4jn&jA

p Y

Y : 4!33jA Y : 4!;3 jA


Okjw 4!> jn&nBB Okjw 4!> jn&nBB

M : ;=jn&24 n! C : ;44jn&jA M : 74jn&hn BB! C : ;4 jn&jA

BB : 29!> n BB : 29!> n

;=jn&24 n p 29!> n : ;44jn&jA p

Y

74jn&hn BB p 29!> n : ;4jn&jA

p Y

Y : 4!;< jA Y : 4!;3 jA

BB : 2>!33 n BB : 2>!33 n

;=jn&24 n p 2>!33 n : ;44jn&jA p

Y

74jn&hn BB p 2>!33 n : ;4jn&jA

p Y

Y : 4!;< jA Y : 4!;= jA

BB : 2>!!!!


35/40

BB : 29!2n BB : 29!2n

;=jn&24 n p 29!2 n : ;44jn&jA p

Y


p Y

Y : 4!;0 jA Y : 4!;3 jA

BB : 27!= n BB : 27!= n;=jn&24 n p 27!= n : ;44jn&jA p

Y

74jn&hn BB p 27!= n : ;4jn&jA

p Y

Y : 4!;> jA Y : 4!;3 jA


Okjw ;!=jn&nBB Okjw ;!=jn&nBB

M: 20jn&24n ! C: ;44 jn&jA M : 74jn&hn BB C : ;4 jn&jA

BB : 33n BB : 33n

20jn&24n p 33n : ;44 jn&jA p Y

74jn&hn BB p 33 n : ;4jn&jA p

Y

Y : 4!=9 jA Y : 4!;> jA

BB : 3=!9> n BB : 3=!9> n

20jn&24n p 3=!9>n : ;44 jn&jA p

Y

74jn&hn BB p 3=!9> n : ;4jn&jA

p Y

Y : 4!=< jA Y : 4!;> jA

BB : 3=!2= n BB : 3=!2= n

20jn&24n p 3=!2= n : ;44 jn&jA p

Y

74jn&hn BB p 3=!2= n : ;4jn&jA

p Y

Y : 4!=0 jA Y : 4!;> jA

BB : 29!>n BB : 29!>n

20jn&24n p 29!>n : ;44 jn&jA p

Y

74jn&hn BB p 29!> n : ;4jn&jA

p Y

Y : 4!3> jA Y : 4!;3 jA

BB : 29!= n BB : 29!= n

20jn&24n p 29!=n : ;44 jn&jA p

Y

74jn&hn BB p 29!= n : ;4jn&jA

p Y

Y : 4!39 jA Y : 4!;3 jA


36/40


Okjw 2!0 jn&nBB Okjw 2!0 jn&nBB

M : 79jn&24n! C: ;44jn&jA M : 74jn&hn BB! C : ;4 jn&jA

BB :2 n BB :2 n

79jn&24n p 2 n : ;44jn&jA p

Y

74jn&hn BB p 2 n : ;4jn&jA

p Y

Y : 4!03jA Y : 4!;7 jA

BB :2>!32 n BB :2>!32 n

79jn&24n p 2>!32 n : ;44jn&jA p

Y

74jn&hn BB p 2>!32 n : ;4jn&jA

p Y

Y : 4!>9jA Y : 4!;= jA

BB :27!37 n BB :27!37 n

79jn&24n p 27!37 n : ;44jn&jA pY

74jn&hn BB p 27!37 n : ;4jn&jAp Y

Y : 4!>;jA Y : 4!;3 jA

BB :27!0 n BB :27!0 n

79jn&24n p 27!0 n : ;44jn&jA p

Y


p Y

Y : 4!>2jA Y : 4!;3 jA

BB :27!3 n BB :27!3 n

79jn&24n p 27!3 n : ;44jn&jA pY

74jn&hn BB p 27!3 n : ;4jn&jAp Y

Y : 4!>;jA Y : 4!;3 jA


37/40

^kh}w

K{wkmgs} (H% Egnk}li, Leiwsk ]%hwecl (4 %> jn&ja, Leiwsk ]%hwecl (;%= jn&ja, Leiwsk ]%hwecl (2%0 jn&ja,

ngalk} ngalk} ngalk} ngalk}

; 2 3 =

hwj

; 2 3 =

hwj

; 2 3 = 7

hwj

; 2 3 = 7

hwj

; 2 3 = 7

hwj

4*7 3 4 2 4 ;!27 4 4 ; 4 4!27 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 2 ; 4!9

7*;4 < < ;4 =

;4*;7 ;; ;4 ;; > ;< 3 = 2 7 > 7 ;; > ;2 ;; ;; = 4 3 7 7 =!= = 0 ; > = >

;7*24 ;= ;2 ;9 ;> 33!>7 = 3 4 7 ;4 < > < < ;4 ; 2 7 < 0 ;4!9 = 7 = > 9 ;2!2

24*27 ;0 ;4 ;> ;; =>!>7 2 2 4 3 ;;!>7 ;4 3 ;2 ;; ;2 2 3 9 < ;2 ;0 7 2 7 9 3 ;9!=

27*34 ;2 0 < = 79 ; 2 4 = ;3!7 0 ; 0 > 9 37!= 9 3 9 0 < 2=!= = ; 3 7 3 ;

34*37 ;4 7 > 3 92!27 4 ; 4 2 ;=!27 > 2 9 0 > =;!= 7 2 3 > > 2

37*=4 ;4 4 7 2 99!7 4 2 ; 2 ;7!7 7 4 4 9 3 ==!2 3 ; ; 3 = 3;!9 2 4 ; 2 ; 23

=4*=7 0 4 3 3 >4 4 2 3 ; ;> 3 4 4 = 2 =9 2 4 ; 2 2 33 ; 4 4 2 ; 23!0

=7*74 4 4 4 4 >4 4 ; ; 4 ;>!7 4 4 4 2 ; =9!9 4 4 4 2 ; 33!9 4 4 4 4 4 23!0

74*77 4 4 4 4 >4 4 4 4 4 ;>!7 4 4 4 3 4 =>!2 4 4 4 4 4 33!9 4 4 4 4 4 23!0

77*94 4 4 4 4 >4 4 4 4 4 ;>!7 4 4 4 4 4 =>!2 4 4 4 4 4 33!9 4 4 4 4 4 23!0

=> 27 == 97 77 3= ;; 27 =0 74 27 ;0 ;9 3> 23

>4 ;>%7 =>%2 33%9 23%0

Tgrsge (', mk|k trf}ghsl

Jgecl}

hg

Tkrksg}kjfa (H% Tfsl}li, Leiwsk }gjw hwecl (4%> jn&ja, Leiwsk }gjw hwecl (;%= jn&ja, Leiwsk }gjw hwecl (2%0 jn&ja,

; 2 3 = ; 2 3 = 7 ; 2 3 = 7 ; 2 3 = 7

'trf}gh 02!09 90!7> 0>!;= 9;!=3 32!09 9=!2< 3>!;= >!;=3 2;!=3 7;!=3 0=!2< 9=!2< 3;!=3 20!7> 9=!2< >=!2< >>!;= =>!;= 9>

>7 32!9 72 99


38/40

AKJTLRKE MK]K

ETkr ]gs}s Mgscrlt}lyg S}k}ls}lcs

E Jgke S}m% Mgylk}lfe Jleljwj Jkpljwj

TGRAKHWKE 23 3%;34= ;%=239>4 32%47=00 *39%44 0>%;4

Feg*Skjtag Hfajfnfrfy*Sjlrefy ]gs}

TGRAKHWKETGRSGEVTRF

]GHSL

E 23 23

Efrjka Tkrkjg}grs(k!b, Jgke 3%;34= =7%>9>4S}m% Mgylk}lfe ;%=23 %>43 %444

^l}`le Nrfwts >>4=%=00 ;0 =20%42>

]f}ka 22947%3=4 22


39/40

Tfs} @fc ]gs}sJwa}ltag Cfjtkrlsfes

Mgtgemge} Ykrlkbag? TGRSGEVTRF]GHSLSc`giig


40/40

@fjfngegfws Swbsg}sTGRSGEVTRF]GHSL

Sc`giig

TGRAKHWKE

E Swbsg} ifr kat`k : %47

; 2 ;

HFE]RFA EGNK]LI = %4444

MFSLS ]GJW HWECL; (4!> jn& jA, 7 32%7904 32%7904

MFSLS ]GJW HWECL2 (;!= jn& jA, 7 72%4444

MFSLS ]GJW HWECL3 (2!0 jn& jA, 7 97%7%4444

Sln% %2>; %40

uji analgesik infusa temu kunci pada mencit betina galur swiss

Documents