Reactions 1339 - 19 Feb 2011

STerlipressin

Peripheral ischaemia: case reportA 51-year-old woman, whose history included alcoholic

cirrhosis, portal hypertension and chronic renal failure,presented to an emergency department with upperdigestive tract bleeding. She received IV terlipressin4 mg/24 hours and developed cyanosis of the toes on thethird day after treatment [duration of treatment to reactiononset not clearly stated]. Terlipressin was immediatelydiscontinued, but her cyanosis progressed to ischaemia ofthe feet with tissue damage. She also developed acute renalfailure and hepatic encephalopathy. Sildenafil was thencommenced with significant improvement; at day 30,complete recovery was observed.Banuelos Ramirez DD, et al. Sildenafil in severe peripheral ischemia induced byterlipressin. A case report. Reumatologia Clinica 7: 59-60, No. 1, Jan-Feb 2011.Available from: URL: http://dx.doi.org/10.1016/j.reuma.2010.05.005 -Mexico 803049528

1

Reactions 19 Feb 2011 No. 13390114-9954/10/1339-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved