Reactions 1341 - 5 Mar 2011

SDesmopressin

Hyponatraemia in an adolescent patient: casereport

A 13-year-old boy, who had panhypopituitarism aftersurgery for a nasofrontal encephalocele during infancy, wasreceiving long-term daily desmopressin [dosage, route andduration of treatment to reaction onset not stated]. He wasadmitted with depressed consciousness and a serumsodium level of 116 mmol/L [treatments not stated]. Over48 hours, rapid overcorrection of his sodium levelsoccurred, and his neurological status worsened. Hedeveloped osmotic myelinolysis and cerebellar oedema; helater died of sudden cardiorespiratory arrest.Ranger A, et al. Osmotic myelinolysis with malignant cerebellar edema occurringafter DDAVP-induced hyponatremia in a child. Pediatric Neurosurgery 46:318-323, No. 4, 2010. Available from: URL: http://dx.doi.org/10.1159/000320146 -Canada 803050349

1

Reactions 5 Mar 2011 No. 13410114-9954/10/1341-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved