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DAFTAR ISI

HALAMAN JUDUL ....................................................................................... i

HALAMAN PENGESAHAN.......................................................................... ii

SURAT PERNYATAAN................................................................................. iii

PRAKATA....................................................................................................... iv

DAFTAR ISI.................................................................................................... vi

DAFTAR SINGKATAN ................................................................................. x

DAFTAR TABEL............................................................................................ xi

DAFTAR GAMBAR ....................................................................................... xii

DAFTAR LAMPIRAN.................................................................................... xiii

INTISARI......................................................................................................... xiv

BAB I PENDAHULUAN .......................................................................... 1

1.1. Latar Belakang ...................................................................... 1

1.2. Rumusan Masalah ................................................................. 3

1.3. Tujuan Penelitian .................................................................. 3

1.3.1. Tujuan Umum ............................................................ 3

1.3.2. Tujuan Khusus............................................................ 4

1.4. Manfaat penelitian ................................................................. 4

1.4.1. Manfaat Teoritis ........................................................ 4

1.4.2. Manfaat Praktis ......................................................... 4

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BAB II TINJAUAN PUSTAKA ................................................................ 5

2.1. Anemia Defisiensi Besi.......................................................... 5

2.1.1. Definisi....................................................................... 5

2.1.2. Etiologi....................................................................... 5

2.1.3. Derajat dan Prevalensi Anemia ................................. 6

2.1.4. Manifestasi ................................................................ 7

2.2. Hemoglobin............................................................................ 8

2.2.1. Definisi....................................................................... 8

2.2.2. Struktur hemoglobin .................................................. 8

2.2.3. Sintesis Hemoglobin .................................................. 9

2.2.4. Fungsi Hemoglobin.................................................... 10

2.2.5. Kadar Normal Hemoglobin........................................ 11

2.3. Zat Besi .................................................................................. 11

2.3.1. Definisi....................................................................... 11

2.3.2. Fungsi zat Besi ........................................................... 12

2.3.3. Absorbsi Besi ............................................................ 13

2.3.4. Metabolisme Zat Besi ................................................ 16

2.4. Asam Folat ............................................................................ 17

2.4.1. Definisi....................................................................... 17

2.4.2. Fungsi Asam Folat ..................................................... 17

2.4.3. Interaksi Asam Folat dan Hemoglobin ...................... 17

2.5. Vitamin A............................................................................... 18

2.5.1. Definisi....................................................................... 18

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2.5.2. Dosis Pemberian Vitamin A....................................... 18

2.5.3. Metabolisme Vitamin A............................................. 19

2.5.4. Transportasi dan Absorbsi Vitamin A ke Hati........... 20

2.5.5. Transportasi dan Absorbsi Vitamin A ke PeriFer ...... 21

2.5.6. Peran Vitamin A......................................................... 21

2.6. Interaksi Vitamin A dengan Besi ........................................... 23

2.7. Interaksi antara Fe, Vitamin A dalam Peningkatan

Hemoglobin............................................................................ 23

2.8. Faktor yang mempengaruhi kadar hemoglobin.................... 24

2.9. Kerangka Teori ...................................................................... 29

2.10. Kerangka Konsep .................................................................. 30

2.11. Hipotesis................................................................................. 30

BAB III METODE PENELITIAN ............................................................... 31

3.1. Jenis Penelitian dan Rancangan Penelitian ........................... 31

3.2. Variabel dan Definisi Operasional ........................................ 31

3.2.1. Variabel ..................................................................... 31

3.2.1.1. Variabel Bebas ............................................ 31

3.2.1.2. Variabel Tergantung .................................... 31

3.2.2. Definisi Operasional ................................................. 31

3.2.2.1.Suplementasi Zat Besi ................................. 31

3.2.2.2.Asam Folat .................................................. 32

3.2.2.3.Vitamin A .................................................... 32

3.2.2.4.Kadar Hemoglobin ..................................... 32

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3.3. Populasi Sampel .................................................................... 32

3.3.1. Populasi Penelitian .................................................... 32

3.3.2. Sampel Penelitian ...................................................... 32

3.3.2.1. Kriteria Inklusi ............................................ 34

3.3.2.2. Kriteria Eksklusi .......................................... 34

3.4. Instrumen dan Bahan Penelitian ............................................ 34

3.5. Tempat dan Waktu ................................................................ 35

3.5.1. Tempat Penelitian ...................................................... 35

3.5.2. Waktu Penelitian ....................................................... 35

3.6. Cara Penelitian ...................................................................... 35

3.7. Analisa Hasil ......................................................................... 36

3.8. Alur Penelitian ...................................................................... 37

BAB IV HASIL DAN PEMBAHASAN ....................................................... 38

4.1. Hasil Penelitian ...................................................................... 38

4.2. Pembahasan............................................................................ 42

BAB V KESIMPULAN DAN SARAN ....................................................... 45

5.1. Kesimpulan ............................................................................ 45

5.2. Saran....................................................................................... 45

DAFTAR PUSTAKA ...................................................................................... 46

LAMPIRAN..................................................................................................... 48