Reactions 1382 - 17 Dec 2011

Cetuximab

Pustular folliculitis: case reportA 46-year-old patient [sex not stated] with metastatic

colon cancer developed pustular folliculitis duringchemotherapy with cetuximab.

The patient presented for the second antibody infusion1 week after initiation of chemotherapy in combinationwith cetuximab [dosage and route not stated]. The patientreported developing a pruritic exanthema soon beforepresentation, which had since developed into an acneiformeruption. The eruption was worst on the nose, but alsoaffected the patient’s back and chest. On examination,there was marked folliculitis of the nose and nasolabialfolds, and less pronounced folliculitis affecting the rest ofthe patient’s face, interscapular back and upper chest; onlyfew erythematous maculae were noted on the remainder ofthe trunk and extremities.

The patient started receiving topical steroids for facialapplication, and a urea cream for application on the rest ofthe body. One cetuximab administration was held, and thedrug was restarted after improvement of the patient’s skinsymptoms.Weisshaupt Ch, et al. Adverse effects of new oncologic therapies. Praxis 100:885-91 quiz 890, No. 15, 27 Jul 2011 [German] - Switzerland 803064086

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Reactions 17 Dec 2011 No. 13820114-9954/10/1382-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved