Reactions 1241 - 28 Feb 2009

Cetuximab

Trichomegaly: case reportA 62-year-old woman with squamous cell cancer

received a cetuximab 400 mg/m2 loading dose 1 weekbefore initiation of radiotherapy with concomitant weeklycetuximab 250 mg/m2. Changes in her eyelashes becamenoticeable within several weeks of starting cetuximabtherapy. She presented with progressive eyelash growth,and associated visual discomfort and inconvenience whenblinking, 4 weeks later. Brittle, aberrant and irregularbilateral eyelash growth was evident on examination of heradnexa. Her symptoms completely resolved 2 months aftercetuximab discontinuation.

Author comment: "[A]rguments are in favour of therelationship between cetuximab and trichomegaly."Vano-Galvan S, et al. Progressive trichomegaly. Netherlands Journal of Medicine67: 35-36, No. 1, Jan 2009 - Spain 801126164

1

Reactions 28 Feb 2009 No. 12410114-9954/10/1241-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved