Reactions 1472, p36 - 5 Oct 2013

STerlipressin

Ischaemia: case reportA 47-year-old man developed ischaemia of the skin during

treatment with terlipressin for bleeding oesophageal varices.He had actively bleeding oesophageal varices and was startedon terlipressin 1mg by injection six times a day. On the thirdday of his treatment, he developed bilateral erythematous,non-blanching lesions of his extremities, ecchymosis withareas of necrosis on the overlying skin and cold extremities.Terlipressin was discontinued and his lesions regressed. Hecompletely recovered in 2 weeks.

Author comment: "[T]he most likely diagnosis we keptwas terlipressin induced-vasculopathy leading to skinischaemia."Sundriyal D, et al. Terlipressin induced ischaemia of skin. BMJ Case Reports2013: [2 pages], No. 010050, 1 Aug 2013. Available from: URL: http://dx.doi.org/10.1136/bcr-2013-010050 - India 803093575

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