Reactions 1434 - 12 Jan 2013

Teriparatide

Bone pain and elevated serum calcium: case reportA 43-year-old woman with hypophosphatasia developed

bone pain and elevated serum calcium levels while receivingteriparatide.

The woman was started on teriparatide 20 µg/day [route notstated] after presenting with a nondisplaced fracture of theright humeral shaft that was painful and pseudoarthriticdespite 3 months of plaster immobilisation. Fifteen days laterdiffuse bone pain occurred, and she required paracetamol. Tenmonths after the start of treatment, the bone pain hadworsened.

The woman’s teriparatide treatment was withdrawn. X-raysand CT scan showed the humeral pseudoarthritis remainedunchanged. Her serum calcium level was 2.70 mmol/L,compared with 2.47 mmol/L prior to treatment [outcome ofreactions not stated].

Author comment: "[T]eriparatide did not modify bALPlevels or BMD and did not improve fracture healing. It causedmarked bone pain and moderately elevated serum calcium".Laroche M. Failure of teriparatide in treatment of bone complications of adulthypophosphatasia. Calcified Tissue International 90: 250, No. 3, Mar 2012.Available from: URL: http://dx.doi.org/10.1007/s00223-011-9562-5 -France 803081749

1

Reactions 12 Jan 2013 No. 14340114-9954/10/1434-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved