staff of pusat pengimejan · 2020. 3. 14. · in the 2012, the pusat pengimejan diagnostik nuklear...

National Research ActivityInternational Research Activity

Research ProgrammesResearch Reports

Staff of Pusat Pengimejan Diagnostik Nuklear 2012 - 2013

Back row (from left): Rosnawati, Nur Hafizah, Komaty, Amar, Ismarezzal, Hafizi, Rosli Front row( from left): Shahrin, Fathinul Fikri, Abdul Jalil, Nasrudin, Hishar

Not in the image: Amir, Kasbillah, Suhayu, Salasiah

ISSN: 977-2289-520005

ANNUAL BOOK 2012(Research Activities & Output)

Cetakan Pertama/First Printing, 24-10-2013Hak Cipta/Copyright Pusat Pengimejan Diagnostik Nuklear,

Universiti Putra Malaysia

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terlebih dahulu.

All rights reserved. No parts of this publication may bereproduced or transmitted in any form or by any means,

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Diterbitkan di Malaysia/Published in Malaysia by

PUSAT PENGIMEJAN DIAGNOSTIK NUKLEAR

UNIVERSITI PUTRA MALAYSIA43000 SERDANG, SELANGOR

Abdul Jalil NordinShahrin Samat

Fathinul Fikri Ahmad SaadHishar HassanRosli Md Yusof

In the 2012, The Pusat Pengimejan Diagnostik Nuklear would be two years old, and we are pleased to introduce the 3rd issue of the Annual Book 2012 in celebration.

It is due to the dedicated efforts by our local researchers and collaborators that our agenda is attracting high quality research works and the effort is becoming more and more crystalised amongst our molecular profession peers.

This book edition offers a valuable documentation on our achievement across the year of 2012 which highlights examples from actual scientific sessions by us, our fellow collaborators, student held nationally and internationally. In other words, it addresses the exemplary works towards ameliorating research in translational imaging which offers another journey in the personalized medicine era.

At this point in time, quality becomes a dominant factor of our success in every means and ways, we are leaping forward without exclusion of our constant commitment with the related industry and communities in the provision of education.

I thank all the contributing efforts by parties for their exceptional works on behalf of PPDN.

Your endless efforts and continuing support have enabled us to move forward to achieve ‘high centre of excellence’.

I wish you all the best.

‘With Knowledge We Serve’

Prof. Dr. Abdul Jalil NordinDirector

Words From The Director

Prof. Dr. Abdul Jalil NordinMID UKM, M Med Rad UMFellowship NMed (Sydney, AUS)Fellowship PET CT (Zurich, SWISS)Preceptorship Cardiac PET (Cleveland, USA)

RESEARch AcTIVITIES AND OUTPUTS 2012-2013iii

Rosetti ClaudioDirector and Associate ProfessorNuclear Medicine and PET/CT Centre,Ospedale Niguarda Ca’ Granda, Piazza Ospedale Maggiore 3,Milan 20126, Italy

Roger I Price (MACPSEM)head, Department of Medical Technology & Physic and RAPID PET LaboratoriesSir Charles Gairdner HospitalAdjunct Professor in School of Physics,University of Western AustraliaPerth, Western Australia

W F Eddie LauDirector of clinical, PETCentre for Cancer Imaging The Peter Mac Callum Cancer Centre,Univ. of MelbourneAustralia

Prof (M) Dr Abdul Rahman MohamadAdjunct Professor in Nuclear MedicineCentre for Diagnostic Nuclear ImagingFaculty of Medicine & Health SciencesUniversiti Putra Malaysia

iv

Associate Council Members

INTERNATIONAL RESEARch AcTIVITIES : RESEARch TEchNOLOGY

RESEARch AcTIVITIES AND OUTPUTS 2012-2013v

Dr Noraini Abdul Rahimconsultant RadiologistNational Cancer Institute,Putrajaya, Malaysia

Prof (M) Dr. S.T. Subhaconsultant ENT SurgeonInternational Medical University Malaysia (IMU)

Dr. Ahmad Fazli Bin Abdul AzizInterventional cardiologistFaculty of Medicine & Health SciencesUniversiti Putra Malaysia

Dr. Ahmad Hisham Bin Abd. RashidOrthopedic SurgeonFaculty of Medicine & Health SciencesUniversiti Putra Malaysia

Assoc. Prof. Dr. M. Iqbal Bin SaripanAssociate ProfessorFaculty of Engineering Universiti Putra Malaysia

Associate Council Members

It is my privilege to welcome you to the insight of the year-round activities and achievement of the Pusat Pengimejan Diagnostik Nuklear, UPM.

It gives us immense pleasure to see PPDN grows by leaps and bounds, and become stronger with each passing day.

Efforts will be made to envisage connections to national and international programmes in the field of research and mobility, which will support molecular imaging as the most challenging era in medical imaging.

This 3rd issue of the annual book highlights multidisciplinary contents, which include continual substantiation of our research activities and hence the yearly research report.

At the end of this preface, I would like to take the opportunity to extend my sincere acknowledgement to all the collaborators and supporting staffs of PPDN, for extending their kind support and co-operation which truly helped PPDN to grow and become as successful as it is today.

The Editor is indebted to his co-Editors on the continual support in making this issue a useful feat. Some small adjustments have been made in the interests of a more rapid generation of material of this publication.

Any remaining errors and infelicities are his alone

I wish you all the best.

Sincerely,

Chief Editor

Editorial PrefaceEditorial Team

chief EditorDr Fathinul Fikri AS

Associate EditorDr Shahrin Samat

Associate EditorHishar Hassan

copy EditorRosli Md. Yusuf

ivRESEARch AcTIVITIES AND OUTPUTS 2012-2013

National Research Activities

International Research Activities

Research Programmes

Research Reports

Table Of Contents

National Research ActivityInternational Research Activity

Research ProgrammesResearch Reports

1

5

9

19

ConferencesMOHE grant meeting

PET/CT workshopResearch Awards

NATIONAL RESEARCHACTIVITIES

1

Mini Symposium on Biotracer Discovery: from bench to bedside23 June 2012

The symposium was aimed at formulating a common research theme in Molecular Imaging whereby the development and use of positron emission tomography (PET), for in vivo functional imaging of tumours can be utilized for the cutting edge research. Most of the lectures in the event highlighted the benefits of the technology employing SUV (quantitative method) of different tumour biology in human subjects as a method of research in presurgical staging of tumour, treatment monitoring, localization of tumour recurrence , prediction of tumour aggressiveness and prognostication of patient survival. Alongside PET, there was also discussion on the role of other molecular imaging technique employing high resolution quantitative autoradiography study i.e mRNA for preclinical and basic imaging research, with a focus on early clinical translational studies.

The event was officiated by Prof. Dato’ Ir. Dr. Mohd Saleh Jaafar, the Deputy Vice Chancellor (Research and Innovation) and was attended by more than 50 scientific research collaborators from various biomedical disciplines.

Achievement: Formation of a translational Research Group in Molecular Imaging, UPM senate has approved a research programme in Molecular imaging in early 2013.

Annual Scientific Meeting of the College of Radiology30th Mar - 1st Apr 2012The annual Scientific Meeting of the College of Radiology provided one of the most important opportunity in showcasing excellence and innovation in Cancer Imaging. The conference committee had put together a very interesting program that could cater for the different needs of the radiologists and radiographers. The program also provided opportunities to network, exchange information, resources and ideas and to explore new and innovative work. There were series of seminars organised by 5 different Special Interest Groups (SIG) - Head & Neck, Paediatrics, Musculoskeletal, Body Imaging and Interventional Radiology. A free oral paper presentation was also held with 9 papers presented. Associate Professor Dr. Ng Chaan from MD Anderson gave a tutorial for those taking their Fellowship of the Royal College of Radiologists, UK or the Masters (Radiology) Programme, which was well attended by more than 20 trainees. Our fellow researcher, Prof. Dr. Abdul Jalil Nordin bagged in silver medal for his outstanding performance in an oral presentation.

Achievement: Achievement: Participated by PPDN membersF.Fathinul, Zanariah H, AJ Nordin. Localisation and prediction of recurrent Phaeochromocytoma/ Paraganglioma(PCC/PGL) using diagnostic 18[F]FDG-PET/CT- PosterF.Fathinul PET-CT in Neuroendocrine Tumour . Guest SpeakerSethu Thakachy Subha , Fathinul AS, Saraiza Abu Bakar, Muhamad Azrif , Abdul Jalil Nordin. The Clinical Outcome of head and neck malignancy patients using integrated Positron Emission Tomography Computed Tomography - an initial experience: Oral Presentation: Abdul Jalil Nordin, Noraini Abdul Rahim, Fathinul AS.Mediastinal mass sampling at percutaneous PET-CT guided biopsy : setting a new course in patient management after multiple futile biopsies: Poster

RESEARch AcTIVITIES AND OUTPUTS 2012-20132

National Conference on Physic 2012 (PERFIK), Colmar Tropicale, Bukit Tinggi, Pahang19-21st November 2012

Malaysian Endocrine Society Annual Congress24th - 27th May 2012

PERFIK 2012 aimed to promote scientific collaboration and research findings among scientists and industries involved in various aspects of basic and applied physics. The conference was held in Colmar Tropicale, Bukit Tinggi, Pahang between 19th to 21st November 2012. Young researchers, participants from industries, universities, governmental research institutions, postgraduate students and interested parties were presented at the event. There were about 80 papers presented during the oral parallel presentation.

Participated Researcher: Hishar Hassan

Achievement: Hishar Hassan, AS Fathinul Fikri, M Salasiah, MN Noramaliza, N Abdul Jalil. Association of total activity 18F-FDG injected with the overall PET image quality in oncology patient: Oral Presentation. The abstract is published in a PERFIK 2012 proceeding book.

Meanwhile the full paper entitled Impact of total activity variation in 18F-FDG injected with the overall PET image quality in oncology patients has been selected for publication in peered reviewed AIP Conference Proceeding (SCOPUS cited).

The conference featured several distinguished speakers who had shared their expertise, and perspectives in various areas of mutual relevance. Apart from updating endocrinologists, physicians, trainees and medical officers in the rapidly growing field of endocrinology and metabolic medicine, the Congress had also served as an occasion where collaborative works in various fields of medicine had taken place to enhance scientific knowledge in the field of endocrinology in particular. The congress was aimed at putting a strong emphasis on current topics in the diagnosis and management of endocrine disorders. Molecular imaging in malignant phaechromocytoma –paraganglioma was a theme for a poster presentation represented by our research collaborator- Dr Teik Hin Tan (National Institute of Malaysia) had added in a new perspective the evaluation of such cancer whereby the use of a new 68 Ga-DOTATATE PET/CT was compared with 18F-FDG PET/CT on the overall accuracy performance.

Partcipated Researcher: Research collaborator

Achievement:Teik Hin Tan, Boon Nang Lee, Fathinul Fikri Ahmad Saad, Zanariah Hussein. Comparison the effectiveness of 131 I-MIBG scintifraphy, 68 Ga-DOTATATE PET/CT and 18F-FDG PET/CT in mapping malignant phaechromocytoma and paraganglioma- Putrajaya experience,- published in the Journal of Endocrine and metabolism (Poster: selected for publication in the Journal of Endocrine and Metabolism).

3RESEARch AcTIVITIES AND OUTPUTS 2012-2013

1 RESEARch AcTIVITIES AND OUTPUTS 2012-20134

Pameran Rekacipta Penyelidikan dan Inovasi Malaysia, (PRPi),UPM19-21 July 2012

Participated Researcher: Dr Fathinul Fikri AS

Title: F.Fathinul, Zanariah H, AJ Nordin Localisation and prediction of recurrent Phaeochromocytoma/ Paraganglioma(PCC/PGL) using diagnostic 18[F]FDG-PET/CT

Achievement:Poster Presentation (Silver Medal)

Conferences / SummitsScientific Visits

International NetworkingRefresher Courses

INTERNATIONAL RESEARCHACTIVITIES


The Health Seminar, USIM19th-20th May 2012

Annual Congress of the European Association of Nuclear Medicine , Milan, Italy October 27 – 31, 2012

The health seminar of Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia (FPSK, USIM) was an international scientific event held annually since the year 2006. The aim of the programme was to foster professional knowledge and enhance research in the field of medicine, with Islam as the foundation.

Attendees to this event were amongst local health professionals, international researchers and medical personnel especially from Islamic countries. USIM’s 1st International Conference on Medicine and Health stimulated new scientific enquiries and academic discourse relating to health issues according to the perspective of the Muslim ummah.

Achievement:Syafinaz Amin Nordin, Faridah Idris, Malina Osman, Rukman Awang Hamat, Fadzillah Ghazali, Fathinul AS. Refusing vaccines, they are not the odd ones out: Poster: Silver medal

The European Association of Nuclear Medicine (EANM) is the umbrella organisation of nuclear medicine in Europe and represents the sector towards the European Institutions. Within this role, the EANM aims at advancing science and education in nuclear medicine for the benefit of public health as well as at promoting and co-coordinating, throughout Europe and beyond, discussion and exchange of ideas and results relating to the diagnosis, treatment, research and prevention of diseases through the use of unsealed radioactive substances and the properties of stable nuclides in medicine.

The goal of the EANM is thus to provide a suitable medium for the dissemination and discussion of the latest results in the field of nuclear medicine and related subjects. Prof. Dr. Abdul jalil Nordin had successfully presented four scientific posters in the field of molecular imaging.

Participated Researcher: Prof. Dr Abdul Jalil Nordin

Achievement: All abstracts presented in the conference are published in Journal of Nuclear Medicine and Molecular Imaging (IF 5.5)

AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, NA Rahim, AS Fathinul Fikri, AZF Azman, C Rossetti. *The value of functional imaging in monitoring anti-tuberculosis treatment using 18F-FDG PET in comparison to morphological 3-dimensional CT changes.

AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, NA Rahim, AS Fathinul Fikri, AZF Azman, C Rossetti. *The performance of nicotinic acid in shifting myocardial metabolism to glucose in 18F-labeled 2-deoxyglucose (FDG) PET-CT myocardial viability assessment.

AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, NA Rahim, AS Fathinul Fikri, AZF Azman, C Rossetti. *Multimodality imaging PET-CT using 18F-labeled 2-deoxyglucose (FDG) ensures effective treatment delivery by improving the staging of head and neck malignancy

AJ Nordin, Agnese, L Deciolo, NA Rahim, AS Fathinul Fikri, AZF Azman, C Rossetti. *State of the art PET-CT technique;one-stop percutaneous PET-CT guided biopsy : a new local experience.

CN192 International Conference on Radiation Protection in Medicine Bonn, Germany3-7 December 2012

12th Annual Teaching Course and International cancer imaging Society Meeting, Oxford, UK4th-6th October 2012

35 participants representing 77 Member States and 16 organizations attended the Conference, which was held at the World Conference Center, Bonn (the former federal government Plenary Chamber).

Prof. Dr. Abdul Jalil Nordin attended the meeting as a mission to promote and expand the molecular imaging agenda pioneered by PPDN in Malaysia.

Achievement: International Research Networking

Solving problems in cancer patientsThe twelfth annual teaching course had focused on ‘solving problems in cancer patients’. Content had structured around clinical and technical stumbling blocks met in everyday practice and offer solutions to these issues.

Achievement:Fathinul AS , AJ Nordin, R Dharmendran, P Vikneswaran . The value of pretreatment PET-CT in predicting survival in patient with esophageal cancer. Abstract is published in the Cancer Imaging Journal (IF. 1.5).



The 68th Korean Congress of Radiology18th-20th October 2012

KSR opened its Congress to the international audience in 2007, and since then the number of sessions operated in English has increased to over 70% of the whole program. The conference had designed a program with high quality scientific sessions for which it had successfully provided a great opportunity for all participants to keep up-to-date with the latest research findings. The conference had featured delegates of more than twenty world renowned scholars from 12 countries. Among them, Dr. Gabriel P. Krestin, who is the current president of ESR, will give the Congress Lecture.

Participated Researcher: Prof. Dr. Abdul Jalil Nordin and Mohd Hafizi Mahmud

Achievement: International Research Networking.Presented posters (published in the proceeding book)

SS 06 CV-01 09:40The value of quantifying myocardial flow reserve in relation to left ventricular function on myocardial perfusion PET-cT using 82Rubidium

Abdul Jalil Nordin1, Wan Azman Wan Ahmad2,Fathinul Fikri Ahmad Saad1, Ahmad Zaid Fattah Azman1, Abdul Latiff Mohamed31Universiti Putra Malaysia, 2Universiti Malaya, 3Cyberjaya University College Medical Science, Malaysia. [email protected]

SE 14 OT-09 The effect of contrast-enhanced cT in integrated 18F-FDG PET/cT imaging of cancer patient

Mohd Hafizi Mahmud1, Abdul Jalil Nordin1,Fathinul Fikri Ahmad Saad1, Ahmad Zaid Fattah Azman2 1Diagnostic Nuclear Imaging Centre, Universiti Putra Malaysia, 2Universiti Putra Malaysia, Malaysia. [email protected]

At the Korean Congress of Radiology, the organiser has chosen the above photographic shot as the best academic photo exhibition for the Academic photographic contest as a side event held in parallel with the main scientific congress

Winner of photo contest at the KCR 2012.

Achievement:Prof Dr Abdul Jalil Nordin bagged in USD 500 as a scientific grant.

OncologyCardiologyInfection

RESEARCHPROGRAMMES

RESEARCH ECOSYSTEM

Programme: Molecular Imaging (hWB 07)Synopsis

In the past decades, we have witnessed the importance of non communicable diseases including coronary artery diseases, malignancy and cerebro-vascular diseases as the main cause of death

in Malaysian hospitals. Molecular imaging is a new field in medicine characterizing, and quantifying the biological processes at the cellular and subcellular levels within intact living organisms. The field exploits specific molecular probes as the source of image contrast where it provides the

imaging signal in almost all molecular imaging assays. The development, validation, and application of this novel imaging technique in living subjects should further enhance our understanding of

disease mechanisms and go hand in hand with targeted personalised therapy. The findings can be correlated with gene expressions and the discovery of novel biomarkers with potential utilization in

drug discovery.

Research Structure

10

Research Administrator(RMC)

Molecular ImagingProf. Dr Abdul Jalil Nordin

(Coordinator:Dr Fathinul Fikri A.S)

Assoc. Prof Dr Shiran Mohd Sidek

Assoc. Prof. Dr. M. Iqbal Saripan

Assoc. Prof. Dr Cheah Yoke Kqueen

Hishar Hassan

Cell Biology & Immunohistology

Science Physic

Molecular Genetic & Genomic

Biomedical Science (Animal Imaging and PET laboratory Technologies)

Molecular Genetic and Genomic

Synopsis:Somatic mutations of the EGFR gene are valuable biomarkers for NSCLC patients. It has been reported that EGFR mutations were more frequently detected in selected sub-population of patients with the following characteristics – female gender, adenocarcinoma histology, Asian origin and non-smokers. Better clinical responses to tyrosine kinase inhibitors (TKIs) were observed in this particular group of patients compared to its counterpart. Thus, EGFR mutation testing is now a standard in the management of advanced lung adenocarcinoma in many of the western countries and in some countries and medical centers in East Asia. In Malaysia, lung cancer is the second most common type of cancer among men and ranked sixth among women. As a multi-racial Asian country, Malaysia is comprised of various ethnics. Therefore, we aim to detect major EGFR mutations in FFPE specimens and examine the associations between the mutations and ethnicity, patient’s gender, age at diagnosis, tumor histology, clinical stage, and smoking history.

Achievements:Nor Asmara Tasrip, Mohd Nasir Mohd Desa, Cheah Yoke Kqueen, Chong Pei Pei, Mar-iana Nor ShamsudinAssociations between Cultural Characteristics and Antibacterial Activities of Streptomyces Isolates: A Preliminary Analysis4th International Conference on Biomedical Engineering in Viet-namIFMBE Proceedings Volume 40, 2013, pp 135-136

Researcher Profile:Assoc. Prof Dr cheah Yoke KqueenSpecialization : Bioinformatic and GeneticField of interest : Biomedical Science

Collaborator Profile:Dr Tiffany Ng Shi YeenMaster Student



Molecular Imaging (Oncology)

Synopsis:Pheochromocytomas are also referred to as adrenal paragangliomas. Paragangliomas originate from the neural crest-derived paraganglia of the autonomic nervous system. These tumors originate from catecholamine-producing chromaffin cells. The increased glucose uptake imaged with Flurodeoxyglucose Positron Emission Tomography (FDG PET) is largely dependent on the rate of glycolysis. FDG uptake and trapping occurs because of upregulation of glucose transporters (notably GLUT1 and GLUT3) and HEXOKINASES I and II . FDG PET imaging also allows quantification of glucose uptake. It is known that in many studies, poor disease prognosis is consistently correlated with increased tumour inherent increased glucose uptake in tumours

Achievements:Localisation and prediction of recurrent Phaeochromocytoma/ Paraganglioma(PCC/PGL) using diagnostic 18[F]FDG-PET/CTAccepted Original Article in Journal of Acta Radiologica (IF:1.3)

Researcher Profile:Dr Fathinul Fikri Ahmad SaadSpecialization : Radiologist Field of interest : Oncology Imaging

Collaborator Profile:Dr. Zanariah husseinSpecialization : EndocrinologistField of interest : Endocrinology

Biomedical Science (Cyclotron, Radionuclides Production & Radiopharmaceuticals)

Synopsis:In view of increasing significance of radiopharmaceuticals in medical diagnosis, niche area of cyclotron, radionuclides production and radiopharmaceuticals possesses an important element in nuclear medicine diagnosis. The physician, specifically the oncologists are no longer preferred the conventional ubiquitous radiopharmaceutical 18F-FDG. New radiopharmaceuticals emerge one after another that are able to provide high sensitivity and specificity when approaching a very specific oncology type disease. Hence, the ability to explore new radiopharmaceuticals either from charged-particle accelerator (cyclotron) or generator, 18F-fluorine based or non- 18F-fluorine based is essential in assisting management of nuclear medicine diagnosis.

Achievements:Hishar H, AS Fathinul Fikri, M Salasiah, MN Noramaliza, N Abdul Jalil. Impact of Total Activ-ity Variation in 18F-FDG Injected with the Overall PET Image Quality in Oncology Patients” has been accepted for publication in American Insti-tute of Physics (AIP)

Researcher Profile:Muhamad hishar hassanSpecialization : Radionuclides production, radiopharmaceuticals and cyclotron

Collaborator Profile:Dr. Roger PriceSpecialization : Medical PhysicistField of interest : cyclotron, Production of Radionuclides and Radiopharmaceutical



Science Physic (Physic and Radiation Protection)

Synopsis:PET CT is a combined multi-modality imaging that provides anatomical locations and functional imaging. The commonly radionuclide used is 18F-FDG ~short half-life (110min). Radioisotope consists of unstable nucleus. Therefore, it will decay to achieve stable configuration of proton and neutron. During radioactive decay, an unstable nucleus spontaneosly decomposes to form a different nucleus, giving off radiation in the form of atomic partices or high energy rays. This decay occurs at a constant, predictable rate that is referred to as half-life.

Achievements:Salasiah M, AJ Nordin, AS Fathinul Fikri, H Hishar, N Tamchek, K Taiman, AK Ahmad BAzli, HA Abdul-Rashid, GA Mahdiraji, R Mizanur, MN Noramaliza Radiation Dose To Radiosensitive Organs In PET Myocardial Perfusion Examination Using Versatile Optical Fibres. SPIE 8775, Micro-structured and Specialty Optical Fibres II, 87750U (May 3, 2013); SPIE Conference Rep. Chezk (2013)- Poster Presentation

Researcher Profile:Salasiah MustafaSpecialization : Science Physic Working Experience : 6 years Field of interest :Science Physic

Collaborator Profile:Prof. Dr. Abdul Jalil NordinSpecialization :Nuclear Radiology Working Experience : 15 years Field of interest : cross Sectional Integrated Nuclear Radiology in cardiology, neurology and infection

Molecular Imaging

Synopsis:

The program is developed with the following objectives :1. Investigating the role of 18F-FDG PET-CT in dementia and vulnerable plague2. Developing normal ASIAN database for Statistical Parametric Mapping analysis, 3. Highlighting the potential of 18F-FDG in other clinical conditions ,4. Incorporating 18F-FDG into routine clinical practice where indicated.

Achievements:Shazreen Shaharuddin, Ahmad Zaid Fat-tah Azman, Katiza Haida Ali, Abdul Latif Mo-hamad, FathinulFikri Ahmad Saad, Abdul Jalil Nordin Vulnerable plaque detection: The role of 18-fluorine fluorodeoxyglucose in iden-tifying high risk patients. Alexandria Medical Journal. 2013. 49(3). In press

Researcher Profile:Prof. Dr. Abdul Jalil NordinSpecialization :Nuclear RadiologyWorking Experience : 15 years Field of interest : cross Sectional Integrated Nuclear Radiology in cardiology, neurology and infection

Collaborator Profile:Prof Dr Maria carla GilardiSpecialization : Nuclear Medicine and Radiopharmaceutical



Science Physic

Synopsis:To evaluate the effect of intravenous contrast media during integrated Positron Emission Tomography Computed Tomography (PET/CT) using fluorine-18 fluorodeoxyglucose (18F-FDG) as tracer in cancer imaging.

This study demonstrates that application of contrast-enhanced CT in PET/CT imaging of cancer patient will cause significant changes on CT values but no significant changes on SUVmax values.

Achievements:The effect of contrast-enhanced CT in integrated 18F-FDF PET/CT imaging of cancer patient. Mohd Hafizi Mahmud, Abdul Jalil Nordin,FathinulFikri Ahmad Saad, Ahmad Zaid Fattah Azman: Poster presentation at KCR 2012.

Researcher Profile:Mohd Hafizi MuhamadSpecialization : Science Physic Working Experience : 6 years Field of interest : Molecular Imaging

Collaborator Profile:Prof. Dr. Abdul Jalil NordinSpecialization :Nuclear RadiologyWorking Experience : 15 years Field of interest : cross Sectional Integrated Nuclear Radiology in cardiology, neurology and infection

Molecular Imaging (Myocardial Viability and Perfusion)

Synopsis:

The program is developed with the following objectives :1. Developing normal LV polar map database for Asian population to be utilized for interpreting viability study,2. Investigating suitable substitute for new protocol for viability study,3. Highlighting the potential of 18F-FDG myocardial viability in identifying patients who will benefit from revascularization. Exploiting FDG PET-CT capability toreduce the number of mis-diagnosed hibernating and infarcted segments ,4. Redefining the normal value of myocardial flow reserve in Malaysian/Asianpopulation ,5. Developing normal LV polar map database for Asian population to be utilized forinterpreting myocardial perfusion study using 82-Rubidium

Achievements:AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, NA Rahim, AS Fathinul Fikri, AZF Azman, C Rossetti. *The performance of nicotinic acid in shifting myocardial metabolism to glucose in 18F-labeled 2-deoxyglucose (FDG) PET-CT my-ocardial viability assessment. Eur J Nucl Med Mol Imaging (2012) 39 (Suppl 2) S3 84-S497A. J. Nordin, W. A. Wan Ahmad, A. L. Ahmad, F. F. Ahmad Saad, A. Z. F. Azman, S. Zuh-di; Serdang/MY, Kuala Lumpur/MY,Cyberjaya/MY. Attenuation corrected PET-CT myocardial perfusion using 82Rubidium allow quantifica-tion of coronary flow reserve with improve left ventricular function assessment - a preliminary experience. (accepted poster for European As-sociation of Radiology. 2013)

Researcher Profile:Prof. Dr. Abdul Jalil NordinSpecialization :Nuclear RadiologyWorking Experience : 15 years Field of interest : cross Sectional Integrated Nuclear Radiology in cardiology, neurology and infection

Collaborator Profile:Prof Dr Abdul Latif MohammadMD cardiologist, cyberjaya Univ college Med Sciences

Dr christian Pirich (MD) Nuclear Medicine. Paracelsius Medical University Salzburg , Austria



Molecular Imaging

Synopsis:Molecular imaging 18f-fdg pet-ct can be used to detect raised metabolism of vascular plaque for early recognition of high risk patient in developing thromboembolic vascular diseases such as coronary artery disease,peripheral arterial disease and cerebrovascular diseases

Achievements:Shazreen Shaharuddin, Ahmad Zaid Fattah Azman, KatizaHaida Ali, Abdul Latif Mohamad, FathinulFikri Ahmad Saad, Abdul Jalil Nordin Vulnerable plaque detection: The role of 18-fluorine fluorodeoxyglucose in identifying high risk patients. Alexandria Medical Journal. 2013. 49(3). In press

Researcher Profile:Profile :Dr Shazreen ShaharuddinSpecialization : Medical PhysiologyWorking Experience : 8 years Field of interest : Molecular Imaging

Collaborator Profile:Prof. Dr. Abdul Jalil NordinSpecialization : Interventional cardiology

Research GrantResearch

Published Manuscripts

RESEARCHREPORTS


INTERNATIONALIZATION Centre For Diagnostic Nuclear Imaging

Putra University Of Malaysia - A Sneak Peek

No Institution

1 University Groningen

2 Milan Bicocca UniversityOspedale NiguardaSan Rafael Hospital

3 Ospedale Monaldi Napoli

4 International Atomic Energy Agency

5 University BresciaUniversity Hospital Brescia

6 University Zurich

1

2

3

564

National And International Research Collaboration With (MOU)

PET-CT Case-Mix Referrals

No Institution Since

1 University of Innsbruck 2012

2 Mc Gills University, Canada 2012


Figure 1: Pie chart shows the case mix of 191 patients by disease categories who underwent PET-CT study at PPDN in 2012

Among the 191 case-mix referrals, the major indication for referrals are for Rb-82 cardiac perfusion (94), oncology (84), MyoPET (6), Neurology (5) and cardiology (46%) followed by infection ( 2),(Fig 1).The number of the Rb-82 cases has shown a staggering rise above the oncology which is attributable to the recruitment of patient under the approved RUGS grant scheme in 2012.


Hospital Referrals

Amount Of The On-Going Research Grants (2012)

Number of Patients

Type Title RM

RUGS The clinical value of multimodality imaging for detecting occult metastatic diseases in ovarian malignancy.

04.02-12-1755RU

RM108,000

RUGS Clinical value of intravenous contrast during whole body 18F-FDG PET CT imaging in cancer patient

04-02-12-1748RU

RM15,000

RUGS Establishing the clinical role of multi-modality imaging in diagnosis of Alzheimer’s disease - pilot study

04-02-12-1749RU

RM30,000

RUGS Optimization of 18F-FDG dose adjusted for whole-body PET oncology examination in CDNI of UPM

04-02-12-1750RU

RM30,000

RUGS Variation in radiation dosimetry for workers in multi-modality imaging PET CT facility

04-02-12-1751RU

RM30,000

171Year2010

Year2011

Year2012

125

192

Number Of Publication (2009-2012)



Research Awards

Year Title Event

2012 SethuThakachySubha ,Fathinul AS Saraiza Abu Bakar, MuhamadAzrif , Abdul JalilNordin.The Clinical Outcome of head and neck malignancy patients using integrated Positron Emission Tomography Computed Tomography - an initial experience

Annual Scientific Meeting of the College of Radiology, AMM 2012

Oral Presentation (Silver Medal)

2012 F.Fathinul, Zanariah H, AJ Nordin Localisation and prediction of recurrent Phaeochromocytoma/ Paraganglioma(PCC/PGL) using diagnostic 18[F]FDG-PET/CT

Pameran Rekacipta Penyelidikan dan Inovasi (PRPi), Malaysia:

Poster Presentation (Silver Medal)

2012 Syafinaz Amin Nordin, FaridahIdris, Malina Osman, RukmanAwangHamat, FadzillahGhazali, FathinulAS.Refusing vaccines, they are not the odd ones out

1st USIM international Conference in Medicine and Health‘Islamic and halal Concept in Medicicne’

Poster: Silver medal

2012 The value of quantifying myocardial flow reserve in relation to left ventricular function on myocardial perfusion PET-CT using 82RubidiumAbdul Jalil Nordin1, Wan Azman Wan Ahmad2,FathinulFikri Ahmad Saad1, Ahmad Zaid Fattah Azman1, Abdul Latiff Mohamed3

68th Korean Congress of Radiology

Travel Grant (USD 500)

2012 Scientific Photo Contest 68th Korean Congress of RadiologyChampion

Professional Consultancy Service

Post Graduated Students (Master in Science)

No Scientific/Peer Group Organisation Designation Year

1 British Journal of Radiology(Prof Dr Abdul Jalil Nordin)

Associate Editor

2012

2 Journal of Medical Diagnostic MethodSpecial issues in Molecular Diagnostic and Critical Medicine (Dr FathinulFikri)

Editor 2012

3 Journal of Medical Diagnostic Method(Dr FathinulFikri)

Reviewer 2012

4 Journal of Medical Oncology (Dr Fathinul Fikri) Reviewer 2012

5 Book Chapter: In Tech(Dr Fathinul Fikri)

Reviewer 2012

6 Book Chapter: iConcept Press(Dr FathinulFikri)

Reviewer 2012

No Name Internship Graduate

1 Mohd Hafizi Mahmud GS30696 2013

2 Noor Nadwa Kamaruddin GS24381 2012

3 Dr Shazreen Shaharudin GS28603 2013

4 Kamarul Amin (UiTM) 2013



ManuscriptsNo Title Journal Status

1 Abdul JalilNordin, Noraini Ibrahim, FathinulFikri, Ahmad Zaid Fatah. The role of contrast Enhanced CT in integrated PET/CT study

Chapter in book).CT Imaging Book. (Chapter 8). Clinical application. InTech, January 2012. ISBN 978-953-307-378-1InTech

published

2 FathinulFikri, AJ Nordin, E F Eddie lau.18[F] FDG-PET/CT is a useful molecular marker in evaluating tumour aggressiveness; a revised understanding of an in- vivo FDGPET imaging that alludes the alteration of cancer biology.

Cell Biochemistry and Biophysic.DOI: 10.1007/s12013-012-9395-5 Pubmed IF 4.32(ISI/Pubmed cited)

published

3 AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, NA Rahim, AS FathinulFikri, AZF Azman, C Rossetti. *The performance of nicotinic acid in shifting myocardial metabolism to glucose in 18F-labeled 2-deoxyglucose (FDG) PET-CT myocardial viability assessment

Eur J Nucl Med Mol Imaging (2012) 39 (Suppl 2) S3 84-S497

accepted

4 AS FathinulFikri, AKroiss , W.F.E Lau, H Zanariah , Z F Ahmad, C Uprimny, E Donnemiller, D Kendler , AJ Nordin, IJ Virgolini . Localisation and prediction of local disease control in recurrent Phaechromocytoma/ Paraganglioma(PCC/PGL) using 18[F]FDG-PET/CT.

ActaRadiologica.(2012). in reviewPubmed IF 1.85

published

5 AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, NA Rahim, AS FathinulFikri, AZF Azman, C Rossetti. *The value of functional imaging in monitoring anti-tuberculosis treatment using 18F-FDG PET in comparison to morphological 3-dimensional CT changes.

Eur J Nucl Med Mol Imaging (2012) 39 (Suppl 2) S3 84-S497PubmedIF 4.5

published

6 Andreas Gunter Bach, Carlos Santiago Restrepo, Jasmin Abbas1, María José Lorenzo Dus,ReinhardSchöpf, FathinulFikri Ahmad Saad, Eddie Lau, Jose Rubio Alvarez, Curd Behrmann,Rolf Peter Spielmann, Alexey Surov. Imaging of nonthrombotic pulmonary embolism.

European Jounal of Radiology.PubmedIF 2.65

published


7 AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, NA Rahim, AS FathinulFikri, AZF Azman, C Rossetti. *Extrapulmonary tuberculosis infection is an important cause of false positive FDG-avidity in PET-CT imaging studies of malignant conditions albeit has potential role in monitoring anti-tuberculosis treatment.


published

8 FathinulAS , AJ Nordin, R Dharmendran, P Vikneswaran. The value of pretreatment PET-CT in predicting survival in patient with esophageal cancer.

Cancer imaging.(2012)Pubmed, Medline, scopus

published

9 AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, NA Rahim, AS FathinulFikri, AZF Azman, C Rossetti.*Multimodality imaging PET-CT using 18F-labeled 2-deoxyglucose (FDG) ensures effective treatment delivery by improving the staging of head and neck malignancy.


published

10 AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, NA Rahim, AS FathinulFikri, AZF Azman, C Rossetti.*Multimodality imaging PET-CT using 18F-labeled 2-deoxyglucose (FDG) ensures effective treatment delivery by improving the staging of head and neck malignancy.


published

11 Abdul JalilNordin, Hisham AR, Fahrudin CH, Husin P, FathinulFikri Ahmad Saad, Ahmad Zaid Fatah. A new clinical approach in detection of hip prosthesis infection using multimodality functional imaging technique 18F –fluorodeoxy glucose (FDG) PET-CT – preliminary data.

Malaysian orthopaedic Journal. 2012. 6 (Supp. A) 22.

published

12 Ahmad Fazli, AJ Nordin, Wan Azman, Fathinul F AS. Database development for myocardial PET-CT using FDG. 2012.

Copyrighted


Proceeding /PosterNo Title

1 SethuThakachySubha ,Fathinul ASSaraiza Abu Bakar, MuhamadAzrif , Abdul JalilNordin.The Clinical Outcome of head and neck malignancy patients using integrated Positron Emission Tomography Computed Tomography - an initial experience .

Annual Scientific Meeting College of Radiology of Malaysia (oral)

2 AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, NA Rahim, AS FathinulFikri, AZF Azman, C Rossetti. *The value of functional imaging in monitoring anti-tuberculosis treatment using 18F-FDG PET in comparison to morphological 3-dimensional CT changes.

EANM’12 – Annual Congress of the European Association of Nuclear Medicine (October 27 – 31, 2012 in Milan/Italy).(poster)

3 AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, NA Rahim, AS FathinulFikri, AZF Azman, C Rossetti. *Extrapulmonary tuberculosis infection is an important cause of false positive FDG-avidity in PET-CT imaging studies of malignant conditions albeit has potential role in monitoring anti-tuberculosis treatment.

CN192 International Conference on Radiation Protection in Medicine – Setting the Scene for the Next Decade 3-7 December 2012 Bonn, Germany) (poster)

4 AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, NA Rahim, AS FathinulFikri, AZF Azman, C Rossetti. *Multimodality imaging PET-CT using 18F-labeled 2-deoxyglucose (FDG) ensures effective treatment delivery by improving the staging of head and neck malignancy

EANM’12 – Annual Congress of the European Association of Nuclear Medicine (October 27 – 31, 2012 in Milan/ITALY). (poster)

5 AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, NA Rahim, AS FathinulFikri, AZF Azman, C Rossetti. *Multimodality imaging PET-CT using 18F-labeled 2-deoxyglucose (FDG) ensures effective treatment delivery by improving the staging of head and neck malignancy

EANM’12 – Annual Congress of the European Association of Nuclear Medicine (October 27 – 31, 2012 in Milan/ITALY). (poster)

6 AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, NA Rahim, AS FathinulFikri, AZF Azman, C Rossetti. *State of the art PET-CT technique;one-stop percutaneous PET-CT guided biopsy : a new local experience.

EANM’12 – Annual Congress of the European Association of Nuclear Medicine. (October 27 – 31, 2012 in Milan/ITALY). (poster)

7 Abdul JalilNordin ,Noraini Abdul Rahim, NorhafizahMokhtaruddin, FathinulFikri, Ahmad Zaid Fattah Azman. Extrapulmonary tuberculosis infection is an important cause of false positive FDG-avidity in PET-CT imaging studies of malignant conditions albeit has potential role in monitoring anti-tuberculosis treatment.

Radiation Protection , IAEA, Bonn, Germany December 2012


8 Abdul JalilNordin1 ,FathinulFikri Ahmad Saad1, Ahmad Fazli Abdul Aziz1, Ahmad Zaid Fattah Azman1 ,Wan Himratul Azliza2, Wan Azman Ahmad2Nicotinic acid as an alternative hypolipidemic agent in shifting myocardial metabolism to glucose in 18F–labeled 2-deoxyglucose (FDG)

PET-CT myocardial viability assessment - update MR cardiac ; Cannes, France April 2012(poster)

9 Abdul JalilNordin ,Noraini Abdul Rahim, FathinulAS.Mediastinal mass sampling at percutaneous PET-CT guided biopsy : setting a new course in patient management after multiple futile biopsies .

Annual Scientific Meeting College of Radiology of Malaysia. Mac 2012 (poster)

10 Abdul JalilNordin ,Fathinul AS , Ahmad Fazli Abdul Aziz1, Ahmad Zaid Fattah Azman,WanHimratulAzliza, Wan Azman Wan Ahmad.The value of quantifying myocardial flow reserve in relation to left ventricular function on myocardial perfusion PET-CT using 82Rubidium.

68th Korean Congress of Radiology, 2012. (poster)

11 FathinulAS , AJ Nordin, R Dharmendran, P Vikneswaran . The value of pretreatment PET-CT in predicting survival in patient with esophageal cancer.

12th Annual Teaching Course and International cancer imaging Society Meeting, Oxford, UK (poster)

12 Syafinaz Amin Nordin, FaridahIdris, Malina Osman, RukmanAwangHamat, FadzillahGhazali, FathinulAS.Refusing vaccines, they are not the odd ones out: a case report

USIM’S 1ST International Health Conference on Medicine and Health Science (poster)

13 Teikhin Tan, Boon Nang Lee, FathinulFikri Ahmad Saad, Zanariah Hussein. Comparison the effectiveness of 131 I-MIBG scintifraphy, 68 Ga-DOTATATE PET/CT and 18F-FDG PET/CT in mapping malignant phaechromocytoma and paraganglioma- Putrajaya experience,

Malaysian Endocrine Society Annual Congress, Mac 2012, Kota Bharu. (poster)


14 FathinulFikri. PET-Ct in neuroendocrine Tumour . Guest Speaker. Annual Scientific Meeting, College of Radiology Malaysia 2012, April 2012 (speaker)

15 FathinulFikri. PET-CT in Cancer Biology (Neuroendocrine Tumour).Speaker.

Mini Symposium on Biotracer Discovery: from bench to bedside.UPM, Malaysia.2012 (speaker)

16 F.Fathinul, Zanariah H, AJ Nordin Localisation and prediction of recurrent Phaeochromocytoma/ Paraganglioma(PCC/PGL) using diagnostic 18[F]FDG-PET/CT.

Pameran Rekacipta Penyelidikan dan Inovasi Malaysia, (PRPi),UPM, 19-21 Julai 2012 (poster)

17 Muhammad Hishar Hassan, FathinulFikri, Abdul jalilNordin. Association of total activity 18F-FDG injected with the overall Pet image quality in oncology patient.

National conference in Physic 2012 (PERFIK) 19-21st November Bukit Tinggi, Pahang.

18 Mohd. Hafizi Mahmud, Muhammad Hishar Hassan, FathinulFikri, Abdul JalilNordin, Ahmad Zaidfatah . The effect of integrating contrast enhanced CT in 18F-FDG PET/CT imaging of cancer patient.

Korean Congress of Radiology, 2012.


Published Manuscript

IF : 2

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Scop

us


IF : 4

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Acknowledgement

H&A Medical Supply Sdn Bhd(760352-T)

Pusat Pengimejan Diagnostik NuklearUniversiti Putra Malaysia

43400 SerdangSelangor Darul Ehsan

Tel : 603-8947 1644Fax : 603-8947 2775

Web : www.ppdn.upm.edu.my

staff of pusat pengimejan · 2020. 3. 14. · in the 2012, the pusat pengimejan diagnostik nuklear...

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