Reactions 1411 - 21 Jul 2012

★Pregabalin

First report of sneezing: case reportA 30-year-old woman with refractory epilepsy and

headaches developed sneezing attacks during treatmentwith pregabalin.

The woman received pregabalin 75 mg/day [route notstated]; sneezing attacks started on the first day oftreatment. Physical and laboratory investigations wereunremarkable. Pregabalin was discontinued after 7 days oftreatment; 18 hours later, the sneezing attacks resolved.

Author comment: "The sneeze attacks that emergesynchronously with the initiation of the pregabalin treatmentand disappear with its discontinuation have not beenreported in the literature before."Akyildiz UO, et al. Pregabalin associated sneezing: A rare side EFFECT. PainPractice 12: 184-185, Feb 2012. Available from: URL: http://dx.doi.org/10.1111/j.1533-2500.2011.00528.x [abstract] - Turkey 803073781

» Editorial comment: A search of AdisBase, Medline andEmbase did not reveal any previous case reports of sneezingassociated with pregabalin. The WHO ADR databasecontained 7 previous reports of sneezing associated withpregabalin.

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Reactions 21 Jul 2012 No. 14110114-9954/10/1411-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved