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8/19/2019 Farmakokinetik Ubat Intravaskuler Komparttemen Dua

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note

warna fase distribusi

warna fase elimininasi

step…. no 1 t cp ln cp cp' cr residual

0.25 43 3.7612 14.309877027 28.690120.5 32 3.465736 13.575952105 18.42405

1 20 2.995732 12.219096319 7.780904

1.5 14 2.639057 10.997852209 3.002148

2 11 2.397895 9.8986659942 1.101334

4 6.5 1.871802

8 2.8 1.029619

12 1.2 0.182322

16 0.52 0.653926

step…. no 2 re!resi titi" fase eliminasi t e"strapo cp ln cp

0 2.7136

4 6.5 1.871802

8 2.8 1.029619

12 1.2 0.182322

16 0.52 0.653926

persamaan eliminasi

#$b%&a

#$o2106%&27136

ln (p $ bt & )

ln (p $ o2106t&27136

se*un!!a+

)$ anti ln a 27136 $ 15083

b$0206,-am

step…. no 3 cari "adar e"strapolasi pda fase distribusi cp'/ den!an m

#$o2106%&27136 masu""an % n#a den!an wa"tu fase

#$o2106025/&27136 $ 2.64825 *asil ini *arus di anti

t distribusi ln cp' #$o2106025/&27136 $ 2.64825/

0.25 2.66095

0.5 2.6083

1 2.503

1.5 2.3977

2 2.2924

step…. no 4 cari residual cr$ cp cp'

2 4 6 8 10 12

1

0.5

0

0.5

1

1.5

2

2.5

f%/ $ 0.2106


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cp cp' cr residual

43 14.30988 28.690122973

32 13.57595 18.424047895

20 12.2191 7.7809036813

14 10.99785 3.0021477911

11 9.898666 1.1013340058

step…. no 5 re!resi linear t s ln cr

t distribusi ln cr cr residual

0.25 3.356553 28.690122973

0.5 2.913657 18.424047895

1 2.051672 7.7809036813

1.5 1.099328 3.0021477911

2 0.096522 1.1013340058

#$b%&a

#$$ 1.8556% & 3.8519

ln (r $ at &

ln (r $ $ 1.8556t & 3.8519

se*in!!a +

$ anti ln a 3.8519 $ 40.2795

a$ 1.8556,-am

baru -awab soaln#a+

$ 40.27 a$ 1.8556,-am

) $ 1508 b$ 0206,-am


3/6

ln cr

3.3565532.913657

2.051672

1.099328

0.096522

n!!una"an persamaan pada e"strapolasi di ats

distribusi

ln "an da*ulu anti ln 2.64825 $ 14129

cp'

14.30988

13.57595

12.2191

10.99785

9.898666

0 2 4 6 8 10 12 14 16 18

1

0

1

2

3

4

14 16 18

20948% & 2.7135751192

(olumn

inear (olumn /


4/6

0 0.5 1 1.5 2 2.5

0

2

4

f%/ $ 1.8555822071% & 3.8519077784

$ 0.9989999242

cr residual

cr residual

inear cr residual/

Axis Title

Axis Title


5/6

(olumn

e"strapolasi

residual


6/6

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