Desmopressin Cyanosis in an infant with severe congenital heart disease: case report

IV desmopressin 0,3 Jig/kg was given to correct prolonged bleeding time noted prior to surgical correction for tetralogy of Fallot in a 21 -month-old boy, He had received a modified right Blalock-Tausig shunt at 6 months, Platelet function was noted to be abnormal.

30 min after starting the infusion, marked cyanosis and dyspnoea were observed, Resuscitation, morphine and fluids were administered to stabil ise the child before surgery, The postoperative course was unremarkable , Because desmopresSln is recommended to reduce blood loss dUring cardiac surgery ', , , it is important to note that some patients

'fh cyanotic cardiac lesions may be ,-4t at risk by the vasodi/atory effect of this drug on the systemic circulation ',

Israels SJ Kobrlnsky NL Serious reac tion t o desmopressln In a child with cyanotic heart disease New England Journal of MediCine 320 1563 1564 8 Jun 1989 •• , -