talian
DESCRIPTION
www.italiansarcomagroup.org. I. I. talian. talian. Started June 1997. S. S. arcoma. arcoma. G. G. roup. roup. Formalized October 2002. 6. 8. 1. 1. 1. 1. 1. 1. 1. 1. 1. 1. 1. 1. 2. 1. 1. 2. 1. 1. 1. 1. 1. 2. 1. 1. 1. 1. 1. 1. 1. 5. 3. 3. 2. 1. - PowerPoint PPT PresentationTRANSCRIPT
Italian
Sarcoma
Group
IItaliantalian
SSarcomaarcoma
GGrouproup
StartedJune 1997
StartedJune 1997
FormalizedOctober 2002Formalized
October 2002
www.italiansarcomagroup.org
68 Centers
• 14 National Institutes
• 14 Universities
• 34 Pubblic Hospitals
• 6 Private Hospitals
68 Centers
• 14 National Institutes
• 14 Universities
• 34 Pubblic Hospitals
• 6 Private Hospitals
Italian Sarcoma GroupItalian Sarcoma Group
210 members210 members
11
1 31
11
18
10 2
1
1 111
1 3
1
1
2 at november 2005at november 2005
11
1 1
1
2
5
1
1BELGIUM
1
1
2
11
11
1
6
1
• ISG/SSG I (localized disease): 3/1997 - 3/2001, 182 pts Closed JCO 2005
• ISG/SSG II (metastatic disease): 3/1998 - 12/2002, 57 pts Closed ASCO 2005
• ISG/OS I (localized disease) activated 4/2001, 237 pts
• EUROBOSS (ISG/SSG/COSS) (> 40 yrs) activated 12/2002, 120 pts
• High risk (relapsed patients) activated 12/2002, 36 pts
• H.D. Samarium + PBSCR in multiple bone lesions activated 11/2005, 6 pts
• ISG/SSG I (localized disease): 3/1997 - 3/2001, 182 pts Closed JCO 2005
• ISG/SSG II (metastatic disease): 3/1998 - 12/2002, 57 pts Closed ASCO 2005
• ISG/OS I (localized disease) activated 4/2001, 237 pts
• EUROBOSS (ISG/SSG/COSS) (> 40 yrs) activated 12/2002, 120 pts
• High risk (relapsed patients) activated 12/2002, 36 pts
• H.D. Samarium + PBSCR in multiple bone lesions activated 11/2005, 6 pts
Osteosarcoma ProtocolsOsteosarcoma ProtocolsItalian Sarcoma GroupItalian Sarcoma Group
• ISG/SSG III (standard risk)activated 6/99, 264 pts ASCO 2007
• ISG/SSG IV (high risk)activated 6/99, 82 pts ASCO 2005
• ISG/AIEOP (very high risk)activated 12/2002, 25 pts
Closed In press EJC 2006
• Relapsed Patientsactivated 12/2002, 32 pts ASCO 2007 ?
• ISG/SSG III (standard risk)activated 6/99, 264 pts ASCO 2007
• ISG/SSG IV (high risk)activated 6/99, 82 pts ASCO 2005
• ISG/AIEOP (very high risk)activated 12/2002, 25 pts
Closed In press EJC 2006
• Relapsed Patientsactivated 12/2002, 32 pts ASCO 2007 ?
Ewing’s Sarcoma ProtocolsEwing’s Sarcoma ProtocolsItalian Sarcoma GroupItalian Sarcoma Group
• ISG/STS0101 (neoadjuvant EpiDOX+IFX, in high risk
localized disease) with Spanish Group (282 pts)
• ISG/STS 03/02 (neodjuvant IFO+RT in retroper. (30 pts)
• HD-IFX in continuous infusion (2nd-4th line) (32 pts)
• Gemcytabine in leiomyosarcomas (2nd-3rd line) (20 pts)
• Miniallogenic Transplant (advanced disease, responsive
patients) (6 pts)
• Phase 2 Trabectedin in myxoid liposarcoma
Other• Imatinib in advanced chordoma (50 pts) (ASCO 2007)
• ISG/STS0101 (neoadjuvant EpiDOX+IFX, in high risk
localized disease) with Spanish Group (282 pts)
• ISG/STS 03/02 (neodjuvant IFO+RT in retroper. (30 pts)
• HD-IFX in continuous infusion (2nd-4th line) (32 pts)
• Gemcytabine in leiomyosarcomas (2nd-3rd line) (20 pts)
• Miniallogenic Transplant (advanced disease, responsive
patients) (6 pts)
• Phase 2 Trabectedin in myxoid liposarcoma
Other• Imatinib in advanced chordoma (50 pts) (ASCO 2007)
Adult soft tissue sarcomas - ProtocolsAdult soft tissue sarcomas - ProtocolsItalian Sarcoma GroupItalian Sarcoma Group
• GIOTTO (observational, 2004-2005, in collaboration with
Novartis) (790 pts) Closed
• REGISTER (retrospective, histhological) (470 pts)
• 62024 (adjuvant Imatinib), intergroup with EORTC
(49/418 pts)
• Institutions from the ISG are participating in the
following studies on new agents in GIST:• Sunitinib (international)
• PTK787 (international)
• Nilotinib (international)
• GIOTTO (observational, 2004-2005, in collaboration with
Novartis) (790 pts) Closed
• REGISTER (retrospective, histhological) (470 pts)
• 62024 (adjuvant Imatinib), intergroup with EORTC
(49/418 pts)
• Institutions from the ISG are participating in the
following studies on new agents in GIST:• Sunitinib (international)
• PTK787 (international)
• Nilotinib (international)
GIST ProtocolsGIST Protocols
In preparation
• Osteosarcoma: localized disease
• Ewing’s sarcoma: localized disease
• Soft tissue sarcomas: high risk, localized
• Surgery in GIST after Imatinib (intergroup)
• Imatinib in localized chordoma
• Imatinib in Chs and fibromatosis