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DAFTAR ISI
KATA PENGANTAR ............................................................................................... vi
DAFTAR ISI .............................................................................................................. viii
DAFTAR GAMBAR ................................................................................................. xi
DAFTAR TABEL ...................................................................................................... xii
DAFTAR LAMPIRAN .............................................................................................. xiii
INTISARI ................................................................................................................... xiv
ABSTRACT ............................................................................................................... xv
BAB I. PENDAHULUAN
A. Latar Belakang Masalah ................................................................................. 1
B. Perumusan Masalah ........................................................................................ 3
C. Tujuan Penelitian ............................................................................................ 3
D. Manfaat Penelitian .......................................................................................... 3
BAB II. STUDI PUSTAKA
A. Tinjauan Pustaka ............................................................................................ 4
1. Uraian tentang lipid dan kolesterol ......................................................... 4
2. Dislipidemia ............................................................................................ 9
3. Terapi dislipidemia .................................................................................. 12
4. Uraian tentang ciplukan .......................................................................... 15
5. Uraian tentang infusa .............................................................................. 17
6. Metode kolorimetri .................................................................................. 18
7. Monografi bahan ..................................................................................... 19
B. Landasan Teori ............................................................................................... 20
C. Hipotesis ......................................................................................................... 21
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BAB III. METODE PENELITIAN
A. Bahan dan Alat ............................................................................................... 22
1. Bahan ....................................................................................................... 22
2. Alat .......................................................................................................... 22
B. Cara Penelitian ............................................................................................... 22
1. Determinasi tanaman ............................................................................... 22
2. Penentuan dosis dan pembuatan infusa herba ciplukan .......................... 22
3. Pembuatan suspensi fenofibrat pada tikus 200 g .................................... 26
4. Pembuatan larutan Na-CMC 1 % ............................................................ 26
5. Pembuatan lemak tinggi .......................................................................... 27
6. Perlakuan hewan uji ................................................................................ 27
7. Analisis kadar kolesterol darah tikus ...................................................... 28
C. Hasil Analisis Statistik ................................................................................... 29
BAB IV. HASIL DAN PEMBAHASAN
A. Pembuatan Infusa Herba Ciplukan ................................................................. 31
1. Determinasi tumbuhan ciplukan.............................................................. 31
2. Pengumpulan dan pembuatan herba ciplukan ......................................... 31
3. Penyarian herba ciplukan secara infundasi ............................................. 32
B. Hasil Uji Pengaruh Pemberian Infusa Herba Ciplukan Terhadap Kadar
Kolesterol Total Dan Berat Badan Hewan Uji ............................................... 32
1. Pengaruh pemberian diet lemak tinggi terhadap peningkatan kadar
kolesterol total serum tikus ..................................................................... 34
2. Pengaruh pemberian infusa herba ciplukan terhadap penurunan kadar
kolesterol total serum tikus ..................................................................... 37
3. Pengaruh pemberian infusa herba ciplukan terhadap penurunan berat
badan tikus .............................................................................................. 43
BAB V. KESIMPULAN DAN SARAN
A. Kesimpulan ..................................................................................................... 47
B. Saran ............................................................................................................... 47
x
DAFTAR PUSTAKA ................................................................................................ 48
LAMPIRAN ............................................................................................................... 50
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DAFTAR GAMBAR
Gambar 1. Struktur kolesterol .................................................................................... 7
Gambar 2. Skema rancangan penelitian ..................................................................... 28
Gambar 3. Tumbuhan ciplukan ................................................................................. 31
Gambar 4. Grafik perubahan kadar kolesterol ........................................................... 38
Gambar 5. Grafik perkembangan berat badan hewan uji ........................................... 45
xii
DAFTAR TABEL
Tabel I. Komponen dan konsentrasi lipoprotein................................................... 4
Tabel II. Klasifikasi LDL dan HDL, kolesterol total, dan trigliserida ................... 11
Tabel III. Klasifikasi total kolesterol dan LDL kolesterol ....................................... 19
Tabel IV. Komponen dan konsentrasi pakan BR-2 ................................................. 19
Tabel V. Komponen dan konsentrasi reagen kit kolesterol ................................... 20
Tabel VI. Data rata-rata kadar kolesterol total hewan uji dan prosentase
peningkatan antara kelompok tanpa diet lemak pada hari ke-14, ke-28,
dan ke-35 dibandingkan dengan hari ke-0 .............................................. 35
Tabel VII. Data rata-rata kadar kolesterol total hewan uji hari ke-0 sebelum
mendapat perlakuan, hari ke-14, ke-28, dan ke-35 setelah
mendapatkan diet lemak tinggi serta hari ke-42 dan ke-49 setelah
perlakuan infusa herba ciplukan .............................................................. 38
Tabel VIII. Persen penurunan kadar kolesterol hewan uji setelah pemberian infusa
herba ciplukan dan pemberian fenofibrat sebagai kontrol positif
selama 14 hari.......................................................................................... 40
Tabel IX. Hasil statistik penurunan kadar kolesterol total antara hari ke-35 dan
hari ke-42 dengan menggunakan uji Tukey atara kontrol positif dengan
infusa ....................................................................................................... 41
Tabel X. Hasil statistik penurunan kadar kolesterol total antara hari ke-35 dan
hari ke-49 dengan menggunakan uji Tukey atara kontrol positif dengan
infusa ....................................................................................................... 42
Tabel XI. Nilai PKBP masing-masing kelompok ................................................... 44
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DAFTAR LAMPIRAN
1. Data perubahan kadar kolesterol total hewan uji ........................................... 50
2. Data perubahan berat badan hewan uji .......................................................... 52
3. Data persen kenaikan kadar kolesterol total................................................... 53
4. Data persen penurunan kadar kolesterol total ................................................ 54
5. Analisis statistik kadar kolesterol total antara cek basal
vs perlakuan lemak tinggi .............................................................................. 55
6. Analisis statistik berat badan hewan uji antara cek basal vs hari ke-35......... 57
7. Analisis statistik penurunan kadar kolesterol total kelompok kontrol
positif hari ke-42 dan ke-49 ........................................................................... 58
8. Analisis statistik penurunan kadar kolesterol total kelompok
infusa ciplukan 2,5 % hari ke-42 dan ke-49 ................................................... 59
9. Analisis statistik penurunan kadar kolesterol total kelompok
infusa ciplukan 5 % hari ke-42 dan ke-49 ...................................................... 60
10. Analisis statistik penurunan kadar kolesterol total kelompok
infusa ciplukan 10 % hari ke-42 dan ke-49 .................................................... 61
11. Analisis statistik penurunan kadar kolesterol total kelompok
infusa ciplukan 20 % hari ke-42 dan ke-49 .................................................... 62
12. Analisis statistik penurunan kadar kolesterol total hari ke-42 ....................... 63
13. Analisis statistik penurunan kadar kolesterol total hari ke-49 ....................... 67
14. Analisis statistik perhitungan nilai PKBP ...................................................... 71
15. Surat keterangan determinasi ......................................................................... 75
16. Surat keterangan hewan uji ............................................................................ 76
17. Prosedur analisis kolesterol ............................................................................ 77
18. Foto bahan ...................................................................................................... 78
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