laporan praktikum farmakologi sedativ

8/18/2019 Laporan Praktikum Farmakologi Sedativ

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LAPORAN PRAKTIKUM FARMAKOLOGI

SEDATIF HIPNOTIK

KELOMPOK PENANGGUNG JAWAB :

1. YULIA RIANI LETELAY 2443013083

2. FRANSISKA SHERLY THUNG 2443013267

3. PUTU KRISNAYANTI 2443013181

4. LOIENA ERONI!A N. 244301331"

#. NATALIA ANASTASYA M. 2443013323

GOLONGAN : $

HARI%WAKTU PRAKTIKUM : SELASA%08.00 & 10.00

FAKULTAS FARMASI

UNIERSITAS KATOLIK WI'YA MAN'ALA SURABAYA

2016

BAB I


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PENDAHULUAN

1.1 LATAR BELAKANG

S()*+, -(/** ((* +,+(- +** /+*5 ),-** )**- )+,+ ()* )**

-(9,*9* (+ ,+, )* -(* (*, ,)* -(-(9*/, (+*)**.M(// H*(+

)* K(( ;2000,(*+

;(?(-*+*


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),**, // -(,-=/* (( *(+(+,. S()*9* *)* (99/** (=*=,* )**

-(,-=/* (( +*-,9 *9 -(?*/ 9(@** +((=(/- +((, +()*+,5 **+,*5

,+*9-/+ )* *+* */ *)* *9 )(*+*. P(99/** =* 99* =*=,/*( *)*

)+,+ ,99, ), -** /* )+,+ =* -(,9* )** -(?**, (( -* *,=* **+,+

*. E( *9 )** ),,-=/* ( 99* +()*, ,, +(*, (( +()*, )*

,,5 )** @/9* -(,-=/* (( *(+(+, ,99* -* (9*/9 *)* )+,+ =*

*9 ),=(,*. E( +((, ,,(/ ),,)*, )(9* (99/** )+,+ )* (*, =* *9

=(*. O( *(* ,/ (?=** ,, ),*/* // -(9(*/, (( =* +()*,( )*

,, +(* -(9*-*, *)** *)*C*)* over )+,+ 99* =* =*=,/*(.

1.2 RUMUSAN MASALAH

Y*9 -(@*), /-/+* -*+** )**- (?=** ,, *)** :

1. A* +*@* (=()** (( =* +()*, )* ,,

2. A* +*@* *)*C*)* ( )+,+ 99* =* =*=,/*(

1.3 HIPOTESA PERCOBAAN

1. P()* (99/** =* +()*, (,* (( ,*9* (+ ,+, ** (*, ,)*

-(9,*9* (+*)**. S()*9* *)* =* ,, (@*), ,*9*

(+*)**.

2. A)** *)*C*)* over )+,+ ;(99/** )+,+ ,99,< +((, )((+,

(**+* )(/ @*/9 *9 +(-*, -(//.

1.4 TUJUAN

T/@/* ),*/* *,/- ,, *)** // -(-=()** (( =* +()*, )*

,, +(* -(9*-*, *)** *)*C*)* over )+,+ 99* =* =*=,/*(.

1.5 MANFAAT PERCOBAAN

M*** (?=** ,, *)** // -(-=(,* ,-*, (*)* (-=*?* -(9(*,

(( =* +()*, ,, +(* -(-=(,* *-=** ,-/ *-*9, (*9 =* +()*,

,, 99* =*=,/*(.

BAB II

LANDASAN TEORI

2.1 Tinjaan T!n"an# O$a"


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2.1.1 P!n##%&%n#an O$a"

P(999* +/*/ =* ( )**- @(,+ +()*,C,,* -(/@/* =**

(9/** (*(/, /*-** *)** -((=*=* +()*+, ;)(9* ),+(*, ,*9*

*+* ?(-*+< **/ -((=*=* */ ;K*D/95 2002


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*(* @** (*-*** (*/ +(-,. P*)* )+,+ (,5 *,)* **

+(),, *9 -(-(9*/, (**+* )* (** )** ;W,,* )*

H*)5 1""#


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+*-*, ( *,* +,+(-,. S((* (-=(,* *5 *)* *+-* /?* =(=*9*,

=(D),*D(, ),?**, )**- */ 05#C850 @*-.

B(D),*D(, )* -(*=, *,* (,* *)* (, *+-*. K(/**

,*** =(/=/9* (* )(9* +,* ,,*.

B(D),*D(, ),-(*=,+-( +(?** (+(+, ( =(=(** +,+(- (D,- ),

*,. B(=(** =(D),*D(, ),-(*=,+-( -(@*), -(*, *9 *, *9 **

),-(*=,+-( (=, *-=* )*, +(** *+**5 +(,99* *-* (@*

=(D),*D(, ,)* +(+/*, )(9* */ */ (,-,*+, =*5 ?*

/*D(*-. M(*=,+-( =(D),*D(, (),, )*, ,9* ** *,/ )(+*,*+,5

,)+,*+, )* @/9*+,.

G*-=* 1. J*/ M(*=,+-( B(=(** B(D),*D(, ;G)-* *) G,-*5 1""0


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A*D*- 150C250 A*D*- 12C1# 151 0564C1534

L*D(*- 250 L*D(*- 8C2# 150C153 057C152

O+*D(*- 150C450 O+*D(*- #C1# 056C250 05"C250

T(-*D(*- 250C350 T(-*D(*- 8C38 154C15# 151C154

T,*D*- 153 T,*D*- 15#C#50 058C158 652C858

• G9* B*=,/*

B*=,/* +(?** * ),*=+=+, ?(* )* +(-/*. B(/ 9**- *,/-

(=, ?(* ),*=+=+, )*, =(/ *+*-*. M/* (@* =(*,*+, +(,* 10C

60-(,5 (9*/9 D* +(* -/* +(),**5 )* ),*-=* ( *)**

-*** )**- *-=/9.

B*=,/* ),),+,==/+, +(?** /*+ )* )** -((*, *+(*5 ,** (,

)(9* *+-* +(+/*, )(9* (*/** )**- (-*.B*=,/* *9 /*9 ,,,5 -,+** *=*=,* )* (=*=,*5

),-(*=,+-( *-, +(-/* ),)**- *, +(=(/- ),(+(+, (* 9,@*.

B*=,/* *9 ),9/** +(=*9*, =* +()*,C,, ,)* -(-,,, */

*/ *9 ?// +,9* // )** ),(,-,*+, +(-/* )**- 24 @*-.

T*=( 2.2. '** F*-*,(, O=* G9* B(D),*D(, ;G)-* *) G,-*5

1""0

;@*-<

M(*=, *, ((,9)**- )**

R**C***/

*/

;@*-<

/-(),+,=/+,

B(+,*

A-=*=,* 250 A-=*=,* 8C42 C C

A=*=,* C A=*=,* 14C34 C C

B/*=*=,* C B/*=*=,* 34C42 C C

P(=*=,* 250 P(=*=,* 1#C48 C C

S(=*=,* 250 S(=*=,* 1#C40 C C

F(=*=,* 650C1850 F(=*=,* 80C120 C C

• G9* S()*,CH,, L*, ;W,,* )* H*)5 1""#


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S(?** * =* ,, =((@* )**- */ 1#C30 -(,. K*)* /?* )**-

)** (?**, )**- */ 1C15# @-. /-( ),+,=/+, ,*C,* 4 %9. O=*

,, )** (* +** /,. W*/ */ ),+,=/+, ,*C,* 1C3 @*- )* */

*/ (,-,*+, +(,* 10C2# @*-. S(,* "0 )*, =* ,, **

),-(*=,+-( ),*,

3. M(,,

S(,* "7 ),-(*=,+-(5 -(*=, +(=*9,* ),,* ( *+*- 9//*.

W*/ */ *)** 4 @*-5 *, ** (=, *-* *)* (*)** ,+,*+,.

M(,, -(*9+*9 +,+,- (D,- -,+-* ), *, )* (D,- )(*C

ALA +,(*+(.

4. M(=*-*

M(=*-* ),*=+=+, +(?** =*, =,* ),=(,* (* *)* /?*

)**- *+-* ),?** )**- 1C3 @*-. S(),, (,* ( (, *+-*.

S(=*9,* =(+* ),-*(=,+-( ), *,5 +(=*9,* (?, ),(+(+, // (*

/,. W*/ */ )*, )+,+ /99* )**- *+-* =(,+* 6C17 @*-5 *-/

*)* (-=(,* , )** -(?**, 24C48 @*-. M(=*-* )**

-(9,)/+, +(=*9,* (D,- -,+- ), *,5 *-/ =(/- ),(*/,

*** )** -(9,)/+, (D,- *9 )** -(-(*=,+-(* +(),,.

#. P**)(,)

S(?** * **)(,) ),*=+=+, ?(* )* ),),+,=/+, +(?** /*+ =* ,,

)** (* +** /,. P*)* )+,+ ,,5 70C80 ),-(*=,+-( ), *,5

+(=*9,* =(+* *9 (+,+* ),(/** (* */C*/5 +(=*9,* (?, (*

/,. W*/ */ +(,* 4C10 @*-. ',(,** =* ,, ), )(,-(,+*+, ),

*, -(@*), *+(*)(,)5 */ ),+,)*+, -(@*), *+*- *+(* *9 (-/),*

),/=* (=, *@/ -(@*), *=),+,)* )* *,.

T*=( 2.3. '** F*-*,(, O=* G9* B(D),*D(, ;G)-* *) G,-*5

1""0

;@*-<

M(*=, *, ((,9

)**- )**

R**C**

*/

*/

;@*-<

/-(

),+,=/+,

B(+,*

K*,)* C T,(* 4C"5# C C

E, C E, 10C2# C C

G/(,-,) C G/(,-,) #C22 C C

M(,, C M(,, 450 C C

M(=*-* 250C350 M(=*-* C C C

P**)(,) 450C1050 P**)(,) C C C


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E,*-* C E,*-* 25# C C

',(,)*-, 250C350 ',(,)*-, 854 45# 652

'+,*-, C '+,*-, 4C12 C C

P,,*-, C P,,*-, C C C

2.1.3 S"')"'

• G9* B(D),*D(,

I+,* B(D),*D(, -(/@/* =*9,* +// *9 (),, **+ ?,?,

=(D( ;A< *9 (/+, *)* ?,?, ),*D(, =(*99* /@/ ;B


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S(?** ,-,*5 =*=,/* -(/** )(,* *+*- =*=,/*. A+*- =*=,/*

;25456C,+(+*,),-,),< -(/** *+, (*+, )(+*+, *** /(*

)(9* *+*- -**. A+*- =*=,/* +(),, ,)* -((=*=* )((+, SSP5 ((

,, )* +()*, +(* (( *,* ),,-=/* =,* *)* +,+, # *)* 9/9/+*

*, **/ *,.

G/9/+ *=, *)* +,+, )/* =(+,* *+*- (-*5 *(* )**

=(*/-(,+*+, =(/ **- ;(< =(*)* )**- (+(,-=*9* )(9* =(/

*,- ;(


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3. M(,,

G*-=* 6. S// K,-,* M(,,

4. M(=*-*

G*-=* 7. S// K,-,* M(=*-*

#. P**)(,)

G*-=* 8. S// K,-,* P**)(,)

6. E,*-*

G*-=* 8. S// K,-,* E,*-*

G*-=* ". N*-* )* S// K,-,* B(=(** G9* S()*,CH,, L*,

;G)-* *) G,-*5 1""0


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2.1.4 FARMADINAMIKA OBAT

H,, )* +()*, -(/** 99* =* ()((+, +/+/* +** /+* ;SSP,,,5 )* *, /+,

)(9* (+, *9 =(=()*C=()*. A)* )/* (( )*, 99* =* ,, *9 =((@*

*)* @*,9* (,( *,/ *+),**+, ( +((* (-=(,* )+,+ (*,

=(D),*D(, ((/ +(?** ,. )* =*)( -/+/* *9 ** (@*), *)*

(-=(,* )+,+ ,99,.

S-nan Sa'a P-a"

P(,9** )+,+ =(D),*D(, -((=*=* )((+, SSP *9 -(,9* )*,

+()*+, ( ,+,+ )* )*, ,+,+ ( +/ (*)** ,, +(,9 ),*** +(=*9*,

(( *(+(+,*5 *, 99* =* ,, ,)* =(*C=(* -(-(,** (( *(+(+,

/-/- *9 +(+,, *(* (+*)** *+,( (* =(** )* (*+*+, *9

),(/* // (-=()** ,)* (?**,.

P, *-*9, =(D),*D(, +*9* =(=()* *)* +(+,(+ *9 =(=()*. P*)*

+(+,(+ ((/5 (* ?=* )** -(,9** (*+*)*** +(=(/- ,-=/


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)((+, SSP. P*)* -(?,5 ,/+ )* -(5 (-=(,* 7C,C=(D),*D(,

-(9,)/+, (*+, ,(*,,*+ *, ,)* *)* +(+,(+ *,. E( (*+*+,

*)* /?,9 )* *,/+, *)* ,/+ +(+/*, )(9* (( +()*+,5 ,+,+ )*

*,*+,(*+ *)* -*/+,*.

P*)* (* ?=*5 =(D),*D(, -(9*-=* *,,*+ =*9,* *9 ),,)/+,

( (,((*D )* ,+,5 *, =*9,* *9 ),,)/+, ( +,, )*

((+ -*+,-* ** ), +/(+, *)* )+,+ *9 -(9*99/ *,,*+ 9(**

. F/*D(*-5 ,*D*-5 *D(*- )* ,*D(*- -(/** *, /+,

*9 (=, +((, ),=*),9* )(,* *,*.

E!) ,a+a EEG +an "in#)a"an "i+'

E( =(D),D(, *)* EEG ;(((+(*9*-< -((/*, ,, +()*, *,.

A,,*+ ** -(//5 *-/ (@*), (,9** )**- *,,*+ ?(* (9*9*

()*. S(=*9,* =(+* =(D),*D(, -(9/*9, */ @*/ ,)/5 (/*-* *)*

(99/** ** )* -(9/*9, @/-* (=*9/ )* */ *9 ),=//*

*)* ,9** 0 ;,9** (@*9*


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=(*. P*)* )+,+ (*(+(+, +(-/* =(D),*D(, )** -(//* (** )**

)* -(*,* )(/ @*/9.

Sa&'an 0!'na

B(D),*D(, ),)/9* )** -(-(=*,, =(=*9*, 9*99/* +*/* ?(* *9

=(/=/9* )(9* *+,(*+.2. Ba'$i"'a"

B*=,/* *)** )(,* *+*- =*=,/*. A+*- =*=,/* +(),, ,)* -((=*=*

)((+, SSP5 (( +()*,C,, )* (( *,* ,-=/ =,* *)* +,+, # *)*

9/9/+* *, **/ *,.

S-nan -a'a ,-a"

E( /*-* =*=,/* *)** )((+, SSP. S(-/* ,9* )((+, )** ),?**,5 -/*,

)*, +()*+,5 ,+,+5 =(=*9*, ,9* *(+(+,*5 -*5 +*-*, (-*,*. P*)*

=(=(** ,),,)/5 )**- (*)** ((/5 -,+** *)** +*,5 =*=,/* ,)*

-((=*=* +()*+, -(*,* -** -(,-=/* (+,*+, ;(9(,+** )*

)(,,/-


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P!'na,a-an +an Si-"!( Ka'+i%/a-)&a'

P(-=(,* =*=,/* )+,+ +()*, *-, ,)* =((9*/ (*)* (**+*5

+()*9* )+,+ ,, * -((=*=* (9/*9* (/(+, )* *-,/)

**+5 (,*+, *( +(),, =(/*95 +(+/*, )(9* (*)** ,)/ ,+,9,+.

P(-=(,* * )+,+ =*=,/* *9 +*9* ,99, **/ +/,* I *9 (*/ ?(*

-((=*=* )((+, **+ (=, =(*.

P*)* )+,+ * +()*, **/ ,,5 =*=,/* ,)* -(-=(,* (( *9 **

(*)* +,+(- *),*+/*. E( *),*+/* *)* ,+,*+, =*=,/*

+(=*9,* =(+* ),+(=*=* ( ,+,* +(/)( *,=* )((+, **+. S(*, ,/5

)+,+ ,99, =*=,/* -((=*=* )((+, /+* *+- ),,/, *+),**+,

(,( +(,99* (@*), ,(+,. B*=,/* )+,+ +*9* ,99, =((9*/

*9+/9 (*)* *,( +(,99* -((=*=* + *),*+/*.Ha"i

E( =*=,/* (*)* *, *9 *,9 ),(* ,** ((* (*)* +,+(-

-(*=,+-( =* ), -,+-. B*=,/* =(+*-* )(9* +,- P4#0 +(?**

-(,, -(-(9*/, =,*+-*+, =* +(* D* ()9( )**- /=/

-,+** - +(,)5 +(=*,* =(=(** +(** )** -(9*-=*

=,*+-*+, =*=,/*. P(-=(,* =*=,/* +(?** , -(*,* @/-*

(, )* (-* *)* (,/()*+-, *,5 +(* -(*,* *,,*+

9/, *+(*+( )* (D,- +,)*+( +,- P4#0 .3. G%&%n#an -!+a"ii,n%"i) &ain

G9* +()*, ,, *,* /*9 (=, -(-,,, (( *-*),*-,* *9

+*-* )(9* 99* =(D),*D(, -*// =*=,/*.

2.1.5 EFEK SAMPING OBAT

1. B(D),*D(,

B(D),*D(, )** -(,-=/* (( **)+*. M,+**5 /*D(*- +(+(*,

-(,9** ,+,)( -,-, =//5 (/*-* *)* -,99/ (*-* (99/** =*5

*)*9C*)*9 *+,( -(@*), =** =,?**5 ?(-*+5 -/)* (+,99/95 *,*),*

)* =((,9*. G(@** *-(+,*5 (/,*5 9(,+*5 */+,*+,5 )* ,9* */

,-*,* (* (@*), *)* (99/** =(=*9*, =(D),*D(,. K((9*/9*

,9* )** (@*), *)* =** *+,( *9 -(99/** =(D),*D(, )+,+

(*, +(?** (*/ // */ *-*. G(@** //+ =* )** =(/* -*,

(=** (*,* *9 +(-/* ,9, ),=*,5 -,+** ,+-,* )* *+,(*+.

P(99/** =(D),*D(, )+,+ ,99, )**- */ *9 *-* )** -(9*,=**

9(@** //+ =* (=, ** )(9* 9(@** *,/: *9,*+,5 *,5 **,)5 -,*9,*5

(@*9 )* =** /+,.


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S(?** /-/-5 =(D),*D(, -(/** =* *9 (*, *-*5 )+,+ ,99, @**9

-((=*=* (-*,* (?/*, =,* ),9/** =(+*-*C+*-* )(9* )((+* SSP

*9 *, -,+** *.

2. B*=,/*

B*=,/* -(-,,, =(=(** -*?*- (( +*-,9 ),****:*. E( *9(

G(@** ,, -(/** (+,)/ )((+, SSP +((* (( ,, =(*,5 )**

(@*), =(=(** *, +((* (-=(,* =* ),(,*. E( (+,)/ -/9,

=(/* (,95 -/*5 -/* **/ ),*(.

=. E+,*+, **)+*

P*)* =(=(** ,),,)/ (-**,* /*9 =*=,/* ;(/*-* (=*=,* )* NC

)(+-(, =*=,/*< (=, -(,-=/* (+,*+, )*,*)* )((+,. I),+,*+, ,,

(*, /-/- (@*), ),*** *+,( /+,* *@/ )* (=(**9.

?. R*+* (,B*=,/* +(+(*, -(,-=/* -,*9,*5 (/*9,*5 **9,*5 (/*-* *)*

*+,( +,(/,, *9 -()(,* ,+-,*. B,* ),=(,* )**- (*)**

(,5 )** -((=*=* 9(,+*5 (+,*+,5 =** )(,,/-.

). H,(+(+,,,*+

R(*+, *(9, (/*-* (@*), *)* ,),,)/ *9 -()(,* *+-*5 /,*,*5

*9,)(-*5 )* (*)** +(/*. J**9 (@*), )(-*+,+ (+,*,* *9

=(*, ** *)* (99/** (=*=,* (/+, *)* /, *)*9C*)*9

),+(*, )(-*-5 )(,,/-5 )* (/+** )(9((*,.3. H,,C+()*, *,C*,

!: K*,)* -((=*=* ,,*+, *)* /, )* -/+* -(-=*. E(

,,*+, -(,-=/* *+* ,)* (*5 (, (,9*,5 -/* )* *)*9 -/*. O=*

*, *)** -(=*-*5 *)* )+,+ +()*,5 (( +*-,9 /*-* ,** */ )*

**+,*. P*)* )+,+ *9 (=, =(+* +*9* -(9/*9, (-*-/ =(*@* )*

),*+, 9(* )* -(-(*-=* */ (*+,. G(@** (( +*-,9 *, *9

-/9, ),,-=/* *** *,: ,(+,5 *(9, *)* /,5 //*

-=+,(, */5 *9,)(-* )* =++-(.

2.1. In+i)a-i K&ini-

1. B(D),*D(,

B(D),*D(, )** ),9/** // =(=*9*, ,),*+,5 *** *, // (9=**

,+-,*5 *+,(*+5 */ 5 -(),*+, (*(+(+, )* *(+(+,. B(D),*D(,

)(9* */ */ *9 ()( ),(/* +(=*9*, ,,5 **// -(-,,,


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((-** *,/ (,9** (**9/** )* =(** 9(@** //+ =* +((*

(9(,* (99/*** +(?** ,.

2. B*=,/*

2. Tinjaan "!n"an# !an 0%$a M!n0i"6

M(?, -(/** (* ?=* *9 (* ),9/** )**- ((,,* +(@* */

1600*. M(?, @/9* ),9/** )**- =(=*9*, @(,+ ((,,* (-*+/ ((,,* (*9

*(5 ,-/9,5 +,9,5 -(*=,+-5 ((-=*9* =,9,5 ),*=((+5 =(+,*+5

(/** )* ((,,* (*9 *),*+/*. M(?, -(-,,, //* *9 (?,5 */

9((*+, ()(5 )* -/)* =((-=*9 =,* ), )**- *=*,/-. M(?, /, -(-,,,

=// ()( */+ =(** /, +(* ( =(** (-(** )(9* //* (=,

*@*9 )*, *)* =*)* )* (**. M(?, -(-,,, ** =// *9 =(=()* ),+(=*=*

(=()** )**- +, )** -(?, ,* )* -(-,,, ((/* *)* +,*C+,* )/+,

)* ()/+,*. F***-(?, -(/**(* ?=* *9 ?? ),9/** //

((,,**(* -(-,,, **(,+, 9( *9 *-, +*-* )(9* -*/+,* ;S/?5

'*(-*5 )* B* .M(?, -(-,,, *+-, +(=*9*, =(,/:

K,9)- : A,-*,*

F,/- : !)**

K*+ : M*-*,*

O) : R(,*

F*-,, : M/,)*(

G(/+ : M/+

S(+,(+ : Mus musculus

S(+,,,*+ -(?, // (( *9 ),,9,* )* ,)* ),,9,* )*, *(+(+,

=(*,*+, +(?** +,9,,*. H* (+(=/ ),(9*/, ( =(=(** * *,/ /+,*5 ),+,

/=/5 +*/+ (+(**5 (-(*-( )* @(,+ (*-,.M(// (, // -(-(9*9

-(?, *)** )(9* ?** -(** (9/ -(?, +(*@/* ( -(?, ),@(, ),***

(** *9* )* @*, (,9* **/ ((-*.


18/35

BAB III

METODE PRAKTIKUM

3.1 ALAT DAN BAHAN

3.1.1 ALAT

A* *9 ),9/** )**- *,/- ,, *)** :

1. P*-2. R*)

3. E*+, =>

4. H( =*)

#. A* +/, 1 -

6. S)(

7. B(*( 9*++

3.1.2 BAHAN

F(=*=,* #0 -9F(=*=,* 100 -9

A/*)(+

3.2 P!'i"n#an D%-i-

K(- '+,+ (-=(,* /-( P(-=(,*

1 K ;** (-=(,* =*< K ;** (-=(,* =*<

2 F(=*=,* #0-9 052# -%209 BB

3 F(=*=,* #0-9 052# -%209 BB

4 F(=*=,* 100-9 05#0 -%209 BB# F(=*=,* 100-9 05#0 -%209 BB


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K(- '+,+ P(*/*

1 T** (-=(,* =* R*) P*- #51051#520

H(=*) EB

2 F#0 R*) P*- #51051#520

3 F#0 H(=*)5 EB

4 F100 R*) P*- #51051#520

# F100 H(=*)5 EB

3.1.4 S)!(a K!'ja

K%n"'%& K%n"'%&

o R%"a'%+

R*) ),***5 ?** =(** /** ,* -(,

L(** -(?, ),**+ *)

!** */ @*/* -(?, )*, *) *9 -(*)** -/* (@* =*

o EB

G*, -(?, )(9* -(?, *,5 ,+,*** -(?, *9 (* ), /@, *)

L(** -(?, =*/ *)* ** EB ), =*9,* =**

A-*, */ *9 ),(/* -(?, // *, ( ** =*9,* **+

!** */ -(?, +** +*-*, ), =*9,* **+ ** EB


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o P&a"%'(

L(** -(?, *)* *-

A-*, *,,*+5 +,* /=/5 @/-* @(9/* ,* -(,5 (?(** **+%-(,

A-*, *)* -(, ( #5 105 1#5 )* 20

!** *+, *9 ),)**

o H%&!$%a'+

L(** -(?, ), (9* ( =*)

H,/9 @/-* @(9/* (** -(?, ( )**- /=*9 +(*-* # -(,

!** @/-* @(9/* (+(=/

D%-i- F57

R*) ),***5 ?** =(** /** ,* -(,

L(** -(?, ),**+ *)

!** */ @*/* -(?, )*, *) *9 -(*)** -/* (@* =*

I+,*** -(?, +(=(*

B(,* (=*=,* 052# - *)* -(?, +(?** (* -(99/** +)(

)*, (- 2

L*/* /@, *)


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L*/* U@, *-

L(** -(?, *)* *-

A-*, *,,*+5 +,* /=/5 @/-* @(9/* ,* -(,5

(?(** **+%-(,

A-*, *)* -(, ( #5 105 1#5 )* 20

!** *+, *9 ),)**

',9/** -(?, *, *9 +/)* ),=(, (*/* +*-* )(9*

-(?, F#0 ;),=(,* (=*=,* 052# - +(?** (*< )*,

(- 3

L*@/* )(9* /@, EB

!** @/-* @(9/*

H,/9 @/-* @(9/* (**

L(** -(?, ), (9* ( =*)

L*/* U@, H(=*)


22/35

G*, -(?, )(9* -(?, *,5 ,+,*** -(?, *9 (* ), /@, *)

L(** -(?, =*/ *)* ** EB ), =*9,* =**

A-*, */ *9 ),(/* -(?, // *, ( ** =*9,* **+

!** */ -(?, +** +*-*, ), =*9,* **+ ** EB

D%-i- F177

R*) ),***5 ?** =(** /** ,* -(,

L(** -(?, ),**+ *)

!** */ @*/* -(?, )*, *) *9 -(*)** -/* (@* =*

I+,*** -(?, +(=(*

B(,* (=*=,* 05# - *)* -(?, +(?** (* -(99/** +)(

)*, (- 4

L*/* /@, *)


23/35

L*/* U@, *-

L(** -(?, *)* *-

A-*, *,,*+5 +,* /=/5 @/-* @(9/* ,* -(,5(?(** **+%-(,

A-*, *)* -(, ( #5 105 1#5 )* 20

!** *+, *9 ),)**

G*, -(?, )(9* -(?, *,5 ,+,*** -(?, *9 (* ), /@, *)

',9/** -(?, *, *9 +/)* ),=(, (*/* +*-* )(9*

-(?, F100 ;),=(,* (=*=,* 05# - +(?** (*< )*,

(- #

L*@/* )(9* /@, EB

!** @/-* @(9/*

H,/9 @/-* @(9/* (**

L(** -(?, ), (9* ( =*)

L*/* U@, H(=*)


24/35

L(** -(?, =*/ *)* ** EB ), =*9,* =**

A-*, */ *9 ),(/* -(?, // *, ( ** =*9,* **+

!** */ -(?, +** +*-*, ), =*9,* **+ ** EB

C

BAB I8

HASIL DAN PEMBAHASAN

4.1 Ha-i& P'a)"i)(

T*=( 1 P(9*-** /@, *,,*+ *)* *-

KelompokAktivitas Sikap Tubuh

5' 10' 15' 20' 5' 10'15'

20'

Kontrol BAB,grooming,meregang

BAB,grooming,tegang

Grooming,tegang

BAB,tegang

+ + + +

50 mg!"0kgBB

BAB,grooming, ekor

tegang,ber#iri

Grooming, ber#iri

Grooming, ber#iri

BAB + + + +

K(- J/-* @(9/* K(?(** **+ ;+*/*%-(,

# 10 1# 20 # 10 1# 20

K 12 1" 33 1" 330 660 ""0 1320

F #0 -9%70

9BB 6# 18 7 18 120%-, 108%-, 66%-, #4%-,

F100 -9%70

9BB C 4 4 7 7#%-, 70%-, 60%-, #4%-,


25/35

100 mg!"0kgBB

Grooming,mengen#us, ekortegang

Grooming,mengen#us, ekormengen

#ur

Grooming,mengen#us, ekormengen

#ur,#iam#ipinggir, matamenutup, BAB,pipis

$iam#ipinggir, BAB,ekorturun

+ + % %

T*=( 2. P(9*-** *)* H(=*) +(*-* # -(,

K(-

J/-*

@(9/*

K 12F #0 -9%70

9BB 18

F100 -9%70

9BB 41

T*=( 3. P(9*-** *)* R**)

K(-

W*/ @*/

;)(,<

K 108F #0 -9%70

9BB 184

F100 -9%70

9BB 31

T*=( 4. P(9*-** *)* E(?, B*)

K(-

W*/ -(?, )*, =** WB (

/?*

K 108


26/35

F #0 -9%70

9BB184

F100 -9%70

9BB31

4.2 PEMBAHASAN

S()*,C,, *)** +(** *9 )** -((* +,+(- +** /+* +(,99*

-(,-=/* (( +()*+, (-* +*-*, ,)/ /*+. S()*, *)** +(** *9

-(,-=/* +()*+,5 *,/ +/*/ (*)** (@*),* (//* ((** (*)*

*9+*9* )*, /* *(* *)* ((** +,+(- +** /+* *9 ,9* ;S,+*) )*

S(*)@5 1""#


27/35

'*, *+, (9*-** -(99/** *- ), )*** )** @/-* @(9/* )*,

-(?, *)* )+,+ (=*=,* #0-9%209BB (=, =** ),=*),9 )(9* @/-* @(9/*

)*, -(?, *)* )+,+ (=*=,* 100-9%209BB. H* ,, ),*(**5 )(9* (,9**

)+,+ *9 (=, ,99, *)* -(?,5 -** (( +()*+, *9 ),=(,* ** +(-*, =(+*

,99* -(/@/ *)* (( ,,5 * ,, @/9* -(-(9*/, *,,*+ -(?,. '**-

(*)** *9 -*5 -(?, ** -(*/* *,*+ -, +** +*/* *,/

-(@(9/5 )(9* (-=(,* =* +()*+, ** -(//* *,,*+ -, (+(=/5

+(,99* -(?, ,)* =** -(*/* *,,*+. N*-/5 *)* )+,+ (=*=,*

#0-9%209BB @,* ),=*),9* )(9* (- -(/@/* @/-* @(9/*

-(?, *9 (=, ,99,5 * ,, =,+* (@*), *(* =** *5 +** +*/* *)**

(*/* *9 =(=()* )*, +(,* -(?, *9 -(-(9*/, ),+, -(?,. S(+ *9

),,-=/* *)* -(?, )** -(//* *,,*+* +(,99* *)* (-

=,+* +*@* (@*), (//* *,,*+ -(?, )* @/-* @(9/* *9 ),*+,* (=,

+(),, @,* ),=*),9* )(9* (- -(?, *9 ),=(, =* (=*=,*. F*

*,*5 *** *, )*, /( (-=(,* =* *9 ),=(,*. ',-** /( (-=(,* =*

*9 ),=(,* *)** -(/, (*. '(9* /( ( * )** -(-(*-* onset of action

)*, =*5 +(,99* *)* (9*-**5 (( +()*+, *9 ),,-=/* *)* -(?, -*+, =(/-

(,*.

S(*, ,/5 )*, *+, (9*-** -(99/** *- ), )*** )** (?(**

**+ -(?, *9 +(-*, -(// )(9* *)** (,9** )*, )+,+ (=*=,* *9

),=(,* ;),=*),9* )(9* (- < +(* (@*), (//* (?(** **+

-(?, )*, -(, ( # ,99* -(, ( 20. H* ,, ),-/9,* *(* (( )*, =*

(=*=,* *9 -((* /+* *+- ), -()/* *9 -((=*=*

(**+* )*, -(?, -(@*), ,)* (()*,. E( +()*+, )* ,, 99* =*=,/*

-((=*=* )((+, **+ *9 +(=*),9 )(9* =(+**)+,+. P(-=(,* =*=,/*

)+,+ +()*, *-, ,)* =((9*/ (*)* (**+*5 +()*9* )+,+ ,,

-((=*=* (9/*9* (/(+, **+. H* ,, @/9* (,* *)* )** (?(** **+

*)* (-=(,* )+,+ (=*=,* 100-9%209 BB *9 -(9**-, (//* (?(**

**+ *9 +*9* =(+* *(* *)* )+,+ (+(=/ +/)* -(,-=/* (( ,, *)*

-(?,.

'*, )** +,* /=/ -(?, *)* (9*-** *- )** ),(*/, =**

)(9* (,9** )+,+ )** -((=*=* +,+(- ),*+, )*, -(?, -(@*), ,)*

(. H* (+(=/ )** ),,* )*, *,,*+ -(?, *)* -(, ( # ,99* ( 20*)*


28/35

(- -*+, -(/@/* *,,*+C*,,*+ -, -(?, ;9-,95

-((9*95 ( (9*9


29/35

BAB 8

KESIMPULAN DAN SARAN

5.1 KESIMPULAN

1. P(-=(,* (=*=,* *)* )+,+ ()* *,/ #0-9%209 BB -(,-=/* ((

+()*+, *,/ -(9/*9, (?(-*+*5 -(-=(,* *+* (*9. T*, **=,* )+,+*

),,9**5 (( *9 ),*+,* =/* *9, +()*, -(*,* ,, *9 )**

-(,-=/* (*)** +((, ,)/.

2. S(-*, ,99, )+,+ *9 ),=(,* +(-*, =(+* )* ?(* (( +()*, )* ,,

*9 (*), *)* (* ?=*.

5.2 SARAN PENELITIAN

P(9*/ /( (-=(,* )* (=()** (*/* (*)* *,,*+ -(?, @**

;M/+ -/+?//+< *9 ),=(,* =* (=*=,*.


30/35

DAFTAR PUSTAKA

G)-* *) G,-*5 20075 Dasar Farmakologi Terapi5 E),+, 105 ',(@(-** )*,

B**+* I99,+ ( A-*,*5 EG!5 J***.

H*((5 W. 1"835 A*9,++ B(D),*D(,(: /?,* *+(?+5 I B,99,5 G. *)

!+*5 E. Benzodiazepine recognition site ligands: biochemistry and

pharmacology5 2)

().5 R*( P(++5 N( Y5 . 73C"3.H,)**,5 A*. 2013. Ui !fek "edatif !kstrak n#Heksan dari Daun $ratom %Mitragyna

speciosa $orth&' pada Mencit (antan )alur B*+B,c& P,** : U,(+,*+

T*@/9/*.

K*D/95 B.G. ;()+


31/35

TUGAS

1.


32/35

&ipnotik

Anestesi

Koma

bat A

bat B


33/35

A : (,9** )+,+ -()((+, /+* (**+* )* *+- ), -()/*

+*-*, )(9* -* ( -*,

! : =*=,/* )* * ( )( +()*,(C,?+

B : (,9** )+,+ -(9** *)* (*)** *(+(+, /-/-

! : =(D),*D(,( )* ( )/9+

M(*,+-( B(D),*D(,(

• M(-(/* ,,=,+, GABAC(9, *)* +(// ,9* (/*+,+5 (-*+/

+,* ?)5 +/=+*+,* ,9*5 ?(> ?((=(/- )* +((=/-

• I(*+, BCGABA ( -(,9** (@*),* (-=/** ** , ,)*

;-(,9** *,,*+ (+( (*)* GABA*D(*-5

M(=*-*(

2. L9 *?,9:K),*D(>,)(5 K*D(*( ;)/9


34/35

1. U* + *?,9 ;2C4 @*-< :M((>,*5 T,(*5

H(+=*=,*

2. SC,(-(),*( :A-=*=,* ,(-(),*(5 B/*=*=,* ;3C6

@*-


35/35

-(?,*9 -*5 -(?, ** -(-*@* +*-*, =**+ *)* )**- */ 30

)(, ;H*),

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