histo pns dr winarto m kes
Post on 03-Apr-2018
226 views
Embed Size (px)
TRANSCRIPT
7/28/2019 Histo PNS Dr Winarto M Kes
1/62
SYSTEMA NERVORUM
SYSTEMA NERVORUM PERIFERUM
BERKAS SERABUT SARAF
GANGLION
AKHIRAN SARAF SYSTEMA NERVORUM CENTRALE
BERKEMBANG DARI TUBA NEURALIS MENJADI:
OTAK
MEDULLA SPINALIS
7/28/2019 Histo PNS Dr Winarto M Kes
2/62
SYSTEMA NERVORUM
SYSTEMA
NERVORUM
CENTRALE
SYSTEMA
NERVORUM
PERIFERUM
7/28/2019 Histo PNS Dr Winarto M Kes
3/62
SYSTEMA NERVORUM PERIFERUM
MENCAKUP SEMUA JARINGAN SARAF YANG TIDAK
TERCAKUP DALAM SYSTEMA NERVORUM CENTRALE
BERKAS SERABUT SARAF TERBENTUK OLEH TONJOLAN
SARAF TERUTAMA AXON BERSAMA SEL PENYOKONGNYA
DIBUNGKUS OLEH JARINGAN PENGIKAT
GANGLIONDIBENTUK DI BEBERAPA TEMPAT DALAM
TUBUH SEBAGAI KUMPULAN SEL-SEL SARAF BERSAMA
SEL PENYOKONGNYA YANG DIBUNGKUS OLEH JARINGAN
PENGIKAT
7/28/2019 Histo PNS Dr Winarto M Kes
4/62
SERABUT SARAF DALAM SYSTEMA NERVORUM PERIFERUM
7/28/2019 Histo PNS Dr Winarto M Kes
5/62
ORGANISASI SERABUT SARAF
DALAM ANATOMI KITA MELIHAT BERKAS-BERKAS SERABUT SARAF
YANG MASING-MASING DIBERI NAMA, MISALNYA NERVUS RADIALIS,
NERVUS ULNARIS
SERABUT-SERABUT SARAF TERSEBUT SEBENARNYA BERKAS
TONJOLAN SEL SARAF, TERUTAMA AXON
PEMBENTUKAN BERKAS TERORGANISASI SECARA BERTAHAP DENGAN
BUNGKUS JARINGAN PENGIKAT PADAT
BUNGKUS JARINGAN PENGIKAT TERLUAR DINAMAKAN EPINEURIUM
EPINEURIUM MELANJUTKAN KE DALAM MEMBENTUK SEKAT-SEKAT
DAN MEMBUNGKUS BERKAS -BERKAS LEBIH KECIL, DISEBUT:
PERINEURIUM
JARINGAN PENGIKAT TIPIS YANG MEMBUNGKUS SETIAP TONJOLANSARAF BERSAMA MIELIN & SEL SCHWANN: ENDONEURIUM
7/28/2019 Histo PNS Dr Winarto M Kes
6/62
ORGANISASI SERABUT SARAF
Figure 13.3b
7/28/2019 Histo PNS Dr Winarto M Kes
7/62
ORGANISASI SERABUT SARAF
In this preparation,the myelin sheathsare not well fixed.The thicker sheathsare completely
extracted (HA19).The thicker sheathsapparently preventgood fixation of theiraxons so the latter
are not stained andare shrunken.
7/28/2019 Histo PNS Dr Winarto M Kes
8/62
7/28/2019 Histo PNS Dr Winarto M Kes
9/62
ORGANISASI SERABUT SARAF
The endoneurium, immediatelysurrounding the individual axons, can beseen in the transverse sections.Occasionally, blood vessels can be seenleaving the endoneurium (*: HA17). Inlongitudinal sections, the endoneurium ishard to resolve - n: HA18 refers to thelocation of the endoneurium.
The epineurium (E: HA18) surrounds theoutside of each bundle and is composed
mainly of thick collagen fibers that stainlightly here. This is dense connectivetissue which provides the chief structuralintegrity of the bundle.
Lining the epineurial sheath are 3-5 thinlayers of cells that stain more intenselythan the epineurial collagen fibers. Theperineurium (P: HA18) is composed offlattened cell layers. Within each layer,the cells are bound together by occludingjunctions.
7/28/2019 Histo PNS Dr Winarto M Kes
10/62
#68 Nerve bundle in transverse section
Epineurium
Perineurium
7/28/2019 Histo PNS Dr Winarto M Kes
11/62
ORGANISASI SERABUT SARAF
7/28/2019 Histo PNS Dr Winarto M Kes
12/62
7/28/2019 Histo PNS Dr Winarto M Kes
13/62
7/28/2019 Histo PNS Dr Winarto M Kes
14/62
7/28/2019 Histo PNS Dr Winarto M Kes
15/62
SERABUT SARAF SOMATIK DAN VISERAL
7/28/2019 Histo PNS Dr Winarto M Kes
16/62
GANGLION
GANGLION ADALAH KUMPULAN SEL-SEL SARAF YANG
DIBUNGKUS OLEH JARINGAN PENGIKAT PADAT SEBAGAI
KAPSEL GANGLION DAN TERLETAK DI LUAR SSP
KOMPONEN:
SETIAP SEL GANGLION DIBUNGKUS OLEH SEL SATELIT YANG
MERUPAKAN SEL PENYOKONG JARINGAN SARAF
KLASIFIKASI:
GANGLION CRANIO-SPINALIS
DI DAERAH KEPALA DAN DI DAERAH MEDULLA SPINALIS
GANGLION AUTONOM DI LUAR PENGARUH KESADARAN
7/28/2019 Histo PNS Dr Winarto M Kes
17/62
#65 Spinal cord and DRG
Ventral horn
Lateral horn
Dorsal
horn
Dorsal root
ganglion (DRG)
7/28/2019 Histo PNS Dr Winarto M Kes
18/62
Dorsal root ganglion
7/28/2019 Histo PNS Dr Winarto M Kes
19/62
Dorsal root ganglion
Slide 7 Dorsal Root
Ganglion
A higher magnification
view shows thesurrounding satellite
cells (red arrows), the
glia of the DRG.
7/28/2019 Histo PNS Dr Winarto M Kes
20/62
Dorsal root ganglion
7/28/2019 Histo PNS Dr Winarto M Kes
21/62
7/28/2019 Histo PNS Dr Winarto M Kes
22/62
7/28/2019 Histo PNS Dr Winarto M Kes
23/62
Dorsal root ganglion
Next, look for dorsal
root ganglia on either
side of the spinal cord.
They are characterizedby groups of cell bodies
of ganglion cells
alternating with
bundles of axons (HA9).
7/28/2019 Histo PNS Dr Winarto M Kes
24/62
GANGLION CRANIOSPINALIS
MORFOLOGI
BUNGKUS:
JARINGAN PENGIKAT PADAT
DI DAERAH TEPI GANGLION
SEBAGIAN BESAR SEL-SEL GANGLION TERLETAK BERDERET-DERET
DI BAGIAN TENGAH GANGLION
TERUTAMA BERKUMPUL SERABUT SARAF
SEL-SEL SARAF = SEL GANGLION
BERBENTUK PSEUDOUNIPOLER YANG TONJOLANNYA BERBENTUK HURUF T,
KECUALI GANGLION N. ACUSTICUS BERBENTUK BIPOLER
UKURAN SEL: KECIL: 15 m - 30 m; BESAR : 120 m KEDUA TONJOLAN SITOPLASMA SEL GANGLION
MEMPUNYAI STUKTUR SEBAGAI AXON YANG BERMIELIN
TONJOLAN YANG MEMBAWA IMPULS MASUK KE SEL TIDAK
MENUNJUKKAN MORFOLOGI DENDRIT
7/28/2019 Histo PNS Dr Winarto M Kes
25/62
7/28/2019 Histo PNS Dr Winarto M Kes
26/62
JARINGAN GANGLION CRANIOSPINALIS
7
SEL KAPSEL/SATELIT
7/28/2019 Histo PNS Dr Winarto M Kes
27/62
GANGLION AUTONOM
MORFOLOGI
BIASANYA BERBENTUK SEBAGAI PELEBARAN BULAT PADA
SERABUT SARAF AUTONOM
BEBERAPA DI ANTARANYA TERDAPAT DALAM ORGAN, KHUSUSNYA
DALAM DINDING SALURAN PENCERNAAN
SEL-SEL GANGLION
TERSEBAR DALAM GANGLION BERCAMPUR DENGAN SERABUT SARAFYANG LALU LALANG
BERBENTUK NERON MULTIPOLER, SEHINGGA MIRIP GAMBARAN
BINTANG, BERUKURAN HAMPIR SAMA (20 m - 45 m) SERABUT SARAF
TIDAK BERMIELIN
SEL SATELIT
TIDAK SEMPURNA MENGELILINGI SEL GANGLION
7/28/2019 Histo PNS Dr Winarto M Kes
28/62
GANGLION AUTONOM
GANGION SIMAPTIK
SERABUT SARAF
7/28/2019 Histo PNS Dr Winarto M Kes
29/62
#74 Sympathetic ganglion cells
7/28/2019 Histo PNS Dr Winarto M Kes
30/62
JARINGAN GANGLION AUTONOM
GANGLION PARA SIMAPTIK PADA DINDING USUS
7/28/2019 Histo PNS Dr Winarto M Kes
31/62
#75Parasympatheic ganglion cells(in Seminal vesicle)
7/28/2019 Histo PNS Dr Winarto M Kes
32/62
#29 Parasympathetic ganglia
#2 0 P th i li ll i
7/28/2019 Histo PNS Dr Winarto M Kes
33/62
#250Parasympatheic ganglion cells invaginal wall
S d A t i N
7/28/2019 Histo PNS Dr Winarto M Kes
34/62
Sensory and Autonomic Neurons
(DRG) (Parasympatheitc)
7/28/2019 Histo PNS Dr Winarto M Kes
35/62
Axon
Slide 16 Peripheral Nerve
A longitudinal view shows
the characteristics of a
peripheral nerve: a wavy
pattern and a washed-outappearance (from the loss
of myelin during
processing). The RBCs
(about 10 microns each)serve as built-in scale bars.
7/28/2019 Histo PNS Dr Winarto M Kes
36/62
Axon
Slide 17 Peripheral Nerve
Another look shows the
same characteristics of the
longitudinal peripheral
nerve. The washed-outappearance and nodes of
Ranvier distinguish it from
smooth muscle, connective
tissue, cartilage, etc.
7/28/2019 Histo PNS Dr Winarto M Kes
37/62
#67 Longitudinal and Transverse Section of P. Nerve
Axon
Schwann cell
membrane
7/28/2019 Histo PNS Dr Winarto M Kes
38/62
7/28/2019 Histo PNS Dr Winarto M Kes
39/62
Axon
7/28/2019 Histo PNS Dr Winarto M Kes
40/62
Node of Ranvier
7/28/2019 Histo PNS Dr Winarto M Kes
41/62
Slide 18 Node of
Ranvier
A closer look shows a
node of Ranvier (redarrow). These "breaks"
in myelination allow for
saltatory conduction.
Use the RBCs as a sizescale.
7/28/2019 Histo PNS Dr Winarto M Kes
42/62
7/28/2019 Histo PNS Dr Winarto M Kes
43/62
Slide 20 Peripheral
Nerve
In cross section, the
dark axons are clearlyseen within the myelin
sheath (red arrow).
Notice also the smaller
B fibers (blue arrow).They too are
myelinated.
7/28/2019 Histo PNS Dr Winarto M Kes
44/62
7/28/2019 Histo PNS Dr Winarto M Kes
45/62
A Schwann cell myelinateone axon A Schwann cell wraps aroundseveral unmyelinated axons
7/28/2019 Histo PNS Dr Winarto M Kes
46/62
7/28/2019 Histo PNS Dr Winarto M Kes
47/62
Unmyelinated nerve
7/28/2019 Histo PNS Dr Winarto M Kes
48/62
Mixed, myelinated an