amirah zainab binti mamat@muhammad 10-3-41

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AMIRAH ZAINAB BINTI MAMAT@MUHAMMAD 10-3-41

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Page 1: Amirah Zainab Binti Mamat@Muhammad 10-3-41

AMIRAH ZAINAB BINTI MAMAT@MUHAMMAD10-3-41

Page 2: Amirah Zainab Binti Mamat@Muhammad 10-3-41

General architecture of the main salivary glands

• Stroma• Parenchyma • Secretory units(acini)• Myoepithelial cells• Types of Acini • Duct System

Page 3: Amirah Zainab Binti Mamat@Muhammad 10-3-41

Stroma • CT component of salivary

gland that support and convey vascular and nervous supply.

• CT tissue capsule- cover and separate

• CT septa (trabeculae)- arise and divide

• Reticular stroma- infiltrated by lymphocytes and plasma cells

Page 4: Amirah Zainab Binti Mamat@Muhammad 10-3-41

Parenchyma• Secretory units

( Acini)• Acini ( blind sac)• Unit structure formed of group

of secretory cells surrounding a lumen and resting on a basement membrane.

• Acini ( serous/mucous/mixed)• Cells are separated from the

basal lamina by modified epithelial cell( basket cells/ myoepithelial cells)

Page 5: Amirah Zainab Binti Mamat@Muhammad 10-3-41

• Myoepithelial cells • Flattened, branched cells with many

processes that acinus like( basket )• Form hemidesmosomal junctions with

basal lamina and desmosomal junctions with acinar and ductal cells they embrace.

• Contain in their cytoplasm abundant actin and myosin filaments which mediate contraction of these cells and squeeze the acinar secretion into the duct.

• Surround also the cells lining the duct system particularly the intercalated ducts. Myoepithelial cells acquire a spindle shape and lie parallel to the length of the duct.

Page 6: Amirah Zainab Binti Mamat@Muhammad 10-3-41

Types of acini found in salivary glands

• Mucous acini • Serous acini• Mixed acini

Page 7: Amirah Zainab Binti Mamat@Muhammad 10-3-41

Mucous acini

Page 8: Amirah Zainab Binti Mamat@Muhammad 10-3-41

Serous Acini

Page 9: Amirah Zainab Binti Mamat@Muhammad 10-3-41

Mixed Acini

Page 10: Amirah Zainab Binti Mamat@Muhammad 10-3-41

Duct system

• The intralobular ducts • The interlobular ducts• The interlobar ducts• The main duct

Page 11: Amirah Zainab Binti Mamat@Muhammad 10-3-41

Intralobular ducts

• Intercalary ducts• thin walled ducts lined by flat or

low cuboidal cells. • Drain the secretory units directly• Represent first segments of the

intralobularducts• Add bicarbonates and adsorb

chlorides from the serous acinar secretion.

• Very short or absent in mucous glands.

• The secretory striated ducts• Intercalary ducts unite together to pour into

larger segments of the intralobular ducts called the secretory striated ducts.

• Salivary glands appear as relatively large, eosinophilic rounded or oval structures with a wide lumen.

• Lined by cuboidal or low columnar cells with indistinct boundaries.

• Have central rounded nucleai and eoisiniophilic granular cytoplasm.

• The basal cell membrane forms deep infoldings lodging mang regularly arranged mitochondria(striated appearance) denote active ion transport across the basal membrane.

• Pump sodium out of the cells and add water to modify saliva as it passes through them.

Page 12: Amirah Zainab Binti Mamat@Muhammad 10-3-41
Page 13: Amirah Zainab Binti Mamat@Muhammad 10-3-41

The interlobular ducts • As terminal part of the

striated secretory ducts leave the lobules, they unit to form larger ducts with a wider lumen.

• Found within the interlobular connective tissue septa between the lobules

• Lined by tall columnar epithelium.

Page 14: Amirah Zainab Binti Mamat@Muhammad 10-3-41

The interlobar ducts

• larger ducts formed by the union of the interlobular ducts as they continue into the interlobar septa between the lobes.

• Lined by tall columnar epithelium

Page 15: Amirah Zainab Binti Mamat@Muhammad 10-3-41

The main duct• Terminal duct of the salivary

gland, which opens into the oral cavity.

• Formed by union of interlobar ducts

• Lined at its beginning by stratified columnar epithelium which gradually becomes non keratinized stratified squamous epithelium similar to that lining the oral cavity where it opens.